Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells

Autores
Toscani, Andrés Martin; Aguilera, Pablo Nicolas; Coluccio Leskow, Federico
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.
Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Aguilera, Pablo Nicolas. Universidad Nacional de Luján; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Coluccio Leskow, Federico. Universidad Nacional de Luján; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
BREAST CANCER
CELL ADHESION RECEPTORS
ERBB2
MEMBRANE CLUSTERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/222297

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network_name_str CONICET Digital (CONICET)
spelling Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cellsToscani, Andrés MartinAguilera, Pablo NicolasColuccio Leskow, FedericoBREAST CANCERCELL ADHESION RECEPTORSERBB2MEMBRANE CLUSTERShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Aguilera, Pablo Nicolas. Universidad Nacional de Luján; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Coluccio Leskow, Federico. Universidad Nacional de Luján; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/222297Toscani, Andrés Martin; Aguilera, Pablo Nicolas; Coluccio Leskow, Federico; Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells; Elsevier Science; FEBS Letters; 596; 21; 10-2022; 2795-28070014-5793CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.14522info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:37Zoai:ri.conicet.gov.ar:11336/222297instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:38.202CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
spellingShingle Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
Toscani, Andrés Martin
BREAST CANCER
CELL ADHESION RECEPTORS
ERBB2
MEMBRANE CLUSTERS
title_short Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title_full Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title_fullStr Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title_full_unstemmed Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title_sort Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
dc.creator.none.fl_str_mv Toscani, Andrés Martin
Aguilera, Pablo Nicolas
Coluccio Leskow, Federico
author Toscani, Andrés Martin
author_facet Toscani, Andrés Martin
Aguilera, Pablo Nicolas
Coluccio Leskow, Federico
author_role author
author2 Aguilera, Pablo Nicolas
Coluccio Leskow, Federico
author2_role author
author
dc.subject.none.fl_str_mv BREAST CANCER
CELL ADHESION RECEPTORS
ERBB2
MEMBRANE CLUSTERS
topic BREAST CANCER
CELL ADHESION RECEPTORS
ERBB2
MEMBRANE CLUSTERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.
Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Aguilera, Pablo Nicolas. Universidad Nacional de Luján; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Coluccio Leskow, Federico. Universidad Nacional de Luján; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/222297
Toscani, Andrés Martin; Aguilera, Pablo Nicolas; Coluccio Leskow, Federico; Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells; Elsevier Science; FEBS Letters; 596; 21; 10-2022; 2795-2807
0014-5793
CONICET Digital
CONICET
url http://hdl.handle.net/11336/222297
identifier_str_mv Toscani, Andrés Martin; Aguilera, Pablo Nicolas; Coluccio Leskow, Federico; Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells; Elsevier Science; FEBS Letters; 596; 21; 10-2022; 2795-2807
0014-5793
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.14522
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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