Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
- Autores
- Toscani, Andrés Martin; Aguilera, Pablo Nicolas; Coluccio Leskow, Federico
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.
Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Aguilera, Pablo Nicolas. Universidad Nacional de Luján; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Coluccio Leskow, Federico. Universidad Nacional de Luján; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
BREAST CANCER
CELL ADHESION RECEPTORS
ERBB2
MEMBRANE CLUSTERS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/222297
Ver los metadatos del registro completo
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Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cellsToscani, Andrés MartinAguilera, Pablo NicolasColuccio Leskow, FedericoBREAST CANCERCELL ADHESION RECEPTORSERBB2MEMBRANE CLUSTERShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Aguilera, Pablo Nicolas. Universidad Nacional de Luján; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Coluccio Leskow, Federico. Universidad Nacional de Luján; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/222297Toscani, Andrés Martin; Aguilera, Pablo Nicolas; Coluccio Leskow, Federico; Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells; Elsevier Science; FEBS Letters; 596; 21; 10-2022; 2795-28070014-5793CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.14522info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:37Zoai:ri.conicet.gov.ar:11336/222297instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:38.202CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
title |
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
spellingShingle |
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells Toscani, Andrés Martin BREAST CANCER CELL ADHESION RECEPTORS ERBB2 MEMBRANE CLUSTERS |
title_short |
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
title_full |
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
title_fullStr |
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
title_full_unstemmed |
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
title_sort |
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
dc.creator.none.fl_str_mv |
Toscani, Andrés Martin Aguilera, Pablo Nicolas Coluccio Leskow, Federico |
author |
Toscani, Andrés Martin |
author_facet |
Toscani, Andrés Martin Aguilera, Pablo Nicolas Coluccio Leskow, Federico |
author_role |
author |
author2 |
Aguilera, Pablo Nicolas Coluccio Leskow, Federico |
author2_role |
author author |
dc.subject.none.fl_str_mv |
BREAST CANCER CELL ADHESION RECEPTORS ERBB2 MEMBRANE CLUSTERS |
topic |
BREAST CANCER CELL ADHESION RECEPTORS ERBB2 MEMBRANE CLUSTERS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway. Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Aguilera, Pablo Nicolas. Universidad Nacional de Luján; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Coluccio Leskow, Federico. Universidad Nacional de Luján; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/222297 Toscani, Andrés Martin; Aguilera, Pablo Nicolas; Coluccio Leskow, Federico; Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells; Elsevier Science; FEBS Letters; 596; 21; 10-2022; 2795-2807 0014-5793 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/222297 |
identifier_str_mv |
Toscani, Andrés Martin; Aguilera, Pablo Nicolas; Coluccio Leskow, Federico; Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells; Elsevier Science; FEBS Letters; 596; 21; 10-2022; 2795-2807 0014-5793 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.14522 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269532165505024 |
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13.13397 |