Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
- Autores
- Rojo, M.; Cristos, Diego Sebastian; González, P.; López-Aca, V.; Dománico, A.; Carriquiriborde, Pedro
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión aceptada
- Descripción
- The accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg-1, 60%; carbamazepine 5.5 (45.8) μg kg-1, 19%; enalapril 7.0 (56.9) μg kg-1, 28%; sildenafil 17.1 (71.6) μg kg-1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish.
Fil: Rojo, M. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: Cristos, Diego Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos; Argentina.
Fil: González, P. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: López-Aca, V. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: Dománico, A. Subsecretaría de Pesca y Acuicultura de La Nación. Dirección de Pesca Continental; Argentina. Comisión de Investigaciones Científicas de La Provincia de Buenos Aires; Argentina. Comisión Administradora Del Río Uruguay; Argentina.
Fil: Carriquiriborde, Pedro. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Comisión Administradora Del Río Uruguay; Argentina. - Fuente
- Chemosphere : 129012 (November 2020)
- Materia
-
Pollutants
Bioaccumulation
Biotransformation of Xenobiotics
Fish
Agentes Contaminantes
Buenos Aires
Bioacumulación
Biotransformación de Xenobióticas
Pescado
Emerging Pollutants
Buenos Aires Metropolitan Area
Contaminantes Emergentes
Área Metropolitana de Buenos Aires - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/8328
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Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata BasinRojo, M.Cristos, Diego SebastianGonzález, P.López-Aca, V.Dománico, A.Carriquiriborde, PedroPollutantsBioaccumulationBiotransformation of XenobioticsFishAgentes ContaminantesBuenos AiresBioacumulaciónBiotransformación de XenobióticasPescadoEmerging PollutantsBuenos Aires Metropolitan AreaContaminantes EmergentesÁrea Metropolitana de Buenos AiresThe accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg-1, 60%; carbamazepine 5.5 (45.8) μg kg-1, 19%; enalapril 7.0 (56.9) μg kg-1, 28%; sildenafil 17.1 (71.6) μg kg-1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish.Fil: Rojo, M. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.Fil: Cristos, Diego Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos; Argentina.Fil: González, P. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.Fil: López-Aca, V. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.Fil: Dománico, A. Subsecretaría de Pesca y Acuicultura de La Nación. Dirección de Pesca Continental; Argentina. Comisión de Investigaciones Científicas de La Provincia de Buenos Aires; Argentina. Comisión Administradora Del Río Uruguay; Argentina.Fil: Carriquiriborde, Pedro. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Comisión Administradora Del Río Uruguay; Argentina.Elsevierinfo:eu-repo/date/embargoEnd/2022-11-262020-11-26T16:00:46Z2020-11-26T16:00:46Z2020-11-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/8328https://www.sciencedirect.com/science/article/abs/pii/S00456535203320940045-6535https://doi.org/10.1016/j.chemosphere.2020.129012Chemosphere : 129012 (November 2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:45:04Zoai:localhost:20.500.12123/8328instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:05.137INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin |
title |
Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin |
spellingShingle |
Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin Rojo, M. Pollutants Bioaccumulation Biotransformation of Xenobiotics Fish Agentes Contaminantes Buenos Aires Bioacumulación Biotransformación de Xenobióticas Pescado Emerging Pollutants Buenos Aires Metropolitan Area Contaminantes Emergentes Área Metropolitana de Buenos Aires |
title_short |
Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin |
title_full |
Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin |
title_fullStr |
Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin |
title_full_unstemmed |
Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin |
title_sort |
Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin |
dc.creator.none.fl_str_mv |
Rojo, M. Cristos, Diego Sebastian González, P. López-Aca, V. Dománico, A. Carriquiriborde, Pedro |
author |
Rojo, M. |
author_facet |
Rojo, M. Cristos, Diego Sebastian González, P. López-Aca, V. Dománico, A. Carriquiriborde, Pedro |
author_role |
author |
author2 |
Cristos, Diego Sebastian González, P. López-Aca, V. Dománico, A. Carriquiriborde, Pedro |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Pollutants Bioaccumulation Biotransformation of Xenobiotics Fish Agentes Contaminantes Buenos Aires Bioacumulación Biotransformación de Xenobióticas Pescado Emerging Pollutants Buenos Aires Metropolitan Area Contaminantes Emergentes Área Metropolitana de Buenos Aires |
topic |
Pollutants Bioaccumulation Biotransformation of Xenobiotics Fish Agentes Contaminantes Buenos Aires Bioacumulación Biotransformación de Xenobióticas Pescado Emerging Pollutants Buenos Aires Metropolitan Area Contaminantes Emergentes Área Metropolitana de Buenos Aires |
dc.description.none.fl_txt_mv |
The accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg-1, 60%; carbamazepine 5.5 (45.8) μg kg-1, 19%; enalapril 7.0 (56.9) μg kg-1, 28%; sildenafil 17.1 (71.6) μg kg-1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish. Fil: Rojo, M. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Fil: Cristos, Diego Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos; Argentina. Fil: González, P. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Fil: López-Aca, V. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Fil: Dománico, A. Subsecretaría de Pesca y Acuicultura de La Nación. Dirección de Pesca Continental; Argentina. Comisión de Investigaciones Científicas de La Provincia de Buenos Aires; Argentina. Comisión Administradora Del Río Uruguay; Argentina. Fil: Carriquiriborde, Pedro. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Comisión Administradora Del Río Uruguay; Argentina. |
description |
The accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg-1, 60%; carbamazepine 5.5 (45.8) μg kg-1, 19%; enalapril 7.0 (56.9) μg kg-1, 28%; sildenafil 17.1 (71.6) μg kg-1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-26T16:00:46Z 2020-11-26T16:00:46Z 2020-11-15 info:eu-repo/date/embargoEnd/2022-11-26 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
acceptedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/8328 https://www.sciencedirect.com/science/article/abs/pii/S0045653520332094 0045-6535 https://doi.org/10.1016/j.chemosphere.2020.129012 |
url |
http://hdl.handle.net/20.500.12123/8328 https://www.sciencedirect.com/science/article/abs/pii/S0045653520332094 https://doi.org/10.1016/j.chemosphere.2020.129012 |
identifier_str_mv |
0045-6535 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess |
eu_rights_str_mv |
restrictedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
Chemosphere : 129012 (November 2020) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
collection |
INTA Digital (INTA) |
instname_str |
Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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