Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin

Autores
Rojo, M.; Cristos, Diego Sebastian; González, P.; López-Aca, V.; Dománico, A.; Carriquiriborde, Pedro
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
The accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg-1, 60%; carbamazepine 5.5 (45.8) μg kg-1, 19%; enalapril 7.0 (56.9) μg kg-1, 28%; sildenafil 17.1 (71.6) μg kg-1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish.
Fil: Rojo, M. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: Cristos, Diego Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos; Argentina.
Fil: González, P. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: López-Aca, V. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: Dománico, A. Subsecretaría de Pesca y Acuicultura de La Nación. Dirección de Pesca Continental; Argentina. Comisión de Investigaciones Científicas de La Provincia de Buenos Aires; Argentina. Comisión Administradora Del Río Uruguay; Argentina.
Fil: Carriquiriborde, Pedro. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Comisión Administradora Del Río Uruguay; Argentina.
Fuente
Chemosphere : 129012 (November 2020)
Materia
Pollutants
Bioaccumulation
Biotransformation of Xenobiotics
Fish
Agentes Contaminantes
Buenos Aires
Bioacumulación
Biotransformación de Xenobióticas
Pescado
Emerging Pollutants
Buenos Aires Metropolitan Area
Contaminantes Emergentes
Área Metropolitana de Buenos Aires
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/8328

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oai_identifier_str oai:localhost:20.500.12123/8328
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network_name_str INTA Digital (INTA)
spelling Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata BasinRojo, M.Cristos, Diego SebastianGonzález, P.López-Aca, V.Dománico, A.Carriquiriborde, PedroPollutantsBioaccumulationBiotransformation of XenobioticsFishAgentes ContaminantesBuenos AiresBioacumulaciónBiotransformación de XenobióticasPescadoEmerging PollutantsBuenos Aires Metropolitan AreaContaminantes EmergentesÁrea Metropolitana de Buenos AiresThe accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg-1, 60%; carbamazepine 5.5 (45.8) μg kg-1, 19%; enalapril 7.0 (56.9) μg kg-1, 28%; sildenafil 17.1 (71.6) μg kg-1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish.Fil: Rojo, M. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.Fil: Cristos, Diego Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos; Argentina.Fil: González, P. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.Fil: López-Aca, V. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.Fil: Dománico, A. Subsecretaría de Pesca y Acuicultura de La Nación. Dirección de Pesca Continental; Argentina. Comisión de Investigaciones Científicas de La Provincia de Buenos Aires; Argentina. Comisión Administradora Del Río Uruguay; Argentina.Fil: Carriquiriborde, Pedro. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Comisión Administradora Del Río Uruguay; Argentina.Elsevierinfo:eu-repo/date/embargoEnd/2022-11-262020-11-26T16:00:46Z2020-11-26T16:00:46Z2020-11-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/8328https://www.sciencedirect.com/science/article/abs/pii/S00456535203320940045-6535https://doi.org/10.1016/j.chemosphere.2020.129012Chemosphere : 129012 (November 2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:45:04Zoai:localhost:20.500.12123/8328instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:05.137INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
title Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
spellingShingle Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
Rojo, M.
Pollutants
Bioaccumulation
Biotransformation of Xenobiotics
Fish
Agentes Contaminantes
Buenos Aires
Bioacumulación
Biotransformación de Xenobióticas
Pescado
Emerging Pollutants
Buenos Aires Metropolitan Area
Contaminantes Emergentes
Área Metropolitana de Buenos Aires
title_short Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
title_full Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
title_fullStr Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
title_full_unstemmed Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
title_sort Accumulation of human pharmaceuticals and biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
dc.creator.none.fl_str_mv Rojo, M.
Cristos, Diego Sebastian
González, P.
López-Aca, V.
Dománico, A.
Carriquiriborde, Pedro
author Rojo, M.
author_facet Rojo, M.
Cristos, Diego Sebastian
González, P.
López-Aca, V.
Dománico, A.
Carriquiriborde, Pedro
author_role author
author2 Cristos, Diego Sebastian
González, P.
López-Aca, V.
Dománico, A.
Carriquiriborde, Pedro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Pollutants
Bioaccumulation
Biotransformation of Xenobiotics
Fish
Agentes Contaminantes
Buenos Aires
Bioacumulación
Biotransformación de Xenobióticas
Pescado
Emerging Pollutants
Buenos Aires Metropolitan Area
Contaminantes Emergentes
Área Metropolitana de Buenos Aires
topic Pollutants
Bioaccumulation
Biotransformation of Xenobiotics
Fish
Agentes Contaminantes
Buenos Aires
Bioacumulación
Biotransformación de Xenobióticas
Pescado
Emerging Pollutants
Buenos Aires Metropolitan Area
Contaminantes Emergentes
Área Metropolitana de Buenos Aires
dc.description.none.fl_txt_mv The accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg-1, 60%; carbamazepine 5.5 (45.8) μg kg-1, 19%; enalapril 7.0 (56.9) μg kg-1, 28%; sildenafil 17.1 (71.6) μg kg-1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish.
Fil: Rojo, M. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: Cristos, Diego Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos; Argentina.
Fil: González, P. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: López-Aca, V. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina.
Fil: Dománico, A. Subsecretaría de Pesca y Acuicultura de La Nación. Dirección de Pesca Continental; Argentina. Comisión de Investigaciones Científicas de La Provincia de Buenos Aires; Argentina. Comisión Administradora Del Río Uruguay; Argentina.
Fil: Carriquiriborde, Pedro. Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones Del Medioambiente (CIM). Facultad de Ciencias Exactas; Argentina. Comisión Administradora Del Río Uruguay; Argentina.
description The accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg-1, 60%; carbamazepine 5.5 (45.8) μg kg-1, 19%; enalapril 7.0 (56.9) μg kg-1, 28%; sildenafil 17.1 (71.6) μg kg-1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-26T16:00:46Z
2020-11-26T16:00:46Z
2020-11-15
info:eu-repo/date/embargoEnd/2022-11-26
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/8328
https://www.sciencedirect.com/science/article/abs/pii/S0045653520332094
0045-6535
https://doi.org/10.1016/j.chemosphere.2020.129012
url http://hdl.handle.net/20.500.12123/8328
https://www.sciencedirect.com/science/article/abs/pii/S0045653520332094
https://doi.org/10.1016/j.chemosphere.2020.129012
identifier_str_mv 0045-6535
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Chemosphere : 129012 (November 2020)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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