Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties

Autores
Bellingeri, Romina; Mulko, Lucinda; Molina, Maria; Picco, Natalia; Alustiza, Fabrisio Eduardo; Grosso, M. Carolina; Vivas, Adriana; Acevedo, Diego F.; Barbero, Cesar A.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes to acrylamide-co-acrylic acid hydrogels. The nanocomposites chemical structure was characterized by Fourier Transform Infrared Spectroscopy (FT-IR). The FT-IR shows the typical bands due to the hydrogel and additionally the peaks at 1750 cm−1 and 1450 cm−1 that correspond to the carbon nanotubes incorporated into the polymer matrix. Mechanical properties and swelling measurements in different buffer solutions were also performed. The nanocomposites showed improved mechanical properties and a stronger pH-response. In order to evaluate antimicrobial activity, the growth and adhesion of Staphylococcus aureus to nanocomposites were studied. Cytocompatibility was also evaluated by MTT assay on MDCK and 3T3 cell lines. The nanocomposites were found to be cytocompatible and showed a reduced bacterial colonization.
EEA Marcos Juárez
Fil: Bellingeri, Romina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina
Fil: Mulko, Lucinda. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina
Fil: Molina, Maria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina
Fil: Picco, Natalia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina
Fil: Alustiza, Fabrisio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina
Fil: Grosso, M. Carolina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina
Fil: Vivas, Adriana. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina
Fil: Acevedo, Diego F. Universidad Nacional de Río Cuarto. Facultad de Ingeniería. Departamento de Tecnología Química; Argentina
Fil: Barbero, Cesar A.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina
Fuente
Materials Science and Engineering: C 90 : 461-467 (September 2018)
Materia
Quitosano
Geles
Nanocompuestos
pH
Propiedades Antimicrobianas
Chitosan
Gels
Nanocomposites
Antimicrobial Properties
Hidrogeles
Propiedades Antibacterianas
Biomateriales
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/2755
Acceder
id INTADig_d3da157ef61880559911df8f8a5db02d
oai_identifier_str oai:localhost:20.500.12123/2755
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial propertiesBellingeri, RominaMulko, LucindaMolina, MariaPicco, NataliaAlustiza, Fabrisio EduardoGrosso, M. CarolinaVivas, AdrianaAcevedo, Diego F.Barbero, Cesar A.QuitosanoGelesNanocompuestospHPropiedades AntimicrobianasChitosanGelsNanocompositesAntimicrobial PropertiesHidrogelesPropiedades AntibacterianasBiomaterialesThe present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes to acrylamide-co-acrylic acid hydrogels. The nanocomposites chemical structure was characterized by Fourier Transform Infrared Spectroscopy (FT-IR). The FT-IR shows the typical bands due to the hydrogel and additionally the peaks at 1750 cm−1 and 1450 cm−1 that correspond to the carbon nanotubes incorporated into the polymer matrix. Mechanical properties and swelling measurements in different buffer solutions were also performed. The nanocomposites showed improved mechanical properties and a stronger pH-response. In order to evaluate antimicrobial activity, the growth and adhesion of Staphylococcus aureus to nanocomposites were studied. Cytocompatibility was also evaluated by MTT assay on MDCK and 3T3 cell lines. The nanocomposites were found to be cytocompatible and showed a reduced bacterial colonization.EEA Marcos JuárezFil: Bellingeri, Romina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; ArgentinaFil: Mulko, Lucinda. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; ArgentinaFil: Molina, Maria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; ArgentinaFil: Picco, Natalia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; ArgentinaFil: Alustiza, Fabrisio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; ArgentinaFil: Grosso, M. Carolina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; ArgentinaFil: Vivas, Adriana. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; ArgentinaFil: Acevedo, Diego F. Universidad Nacional de Río Cuarto. Facultad de Ingeniería. Departamento de Tecnología Química; ArgentinaFil: Barbero, Cesar A.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina2018-07-10T16:52:02Z2018-07-10T16:52:02Z2018-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.sciencedirect.com/science/article/pii/S0928493117335361?via%3Dihubhttp://hdl.handle.net/20.500.12123/27550928-4931https://doi.org/10.1016/j.msec.2018.04.090Materials Science and Engineering: C 90 : 461-467 (September 2018)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-04T09:47:21Zoai:localhost:20.500.12123/2755instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:47:22.153INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
title Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
spellingShingle Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
Bellingeri, Romina
Quitosano
Geles
Nanocompuestos
pH
Propiedades Antimicrobianas
Chitosan
Gels
Nanocomposites
Antimicrobial Properties
Hidrogeles
Propiedades Antibacterianas
Biomateriales
title_short Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
title_full Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
title_fullStr Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
title_full_unstemmed Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
title_sort Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
dc.creator.none.fl_str_mv Bellingeri, Romina
Mulko, Lucinda
Molina, Maria
Picco, Natalia
Alustiza, Fabrisio Eduardo
Grosso, M. Carolina
Vivas, Adriana
Acevedo, Diego F.
Barbero, Cesar A.
author Bellingeri, Romina
author_facet Bellingeri, Romina
Mulko, Lucinda
Molina, Maria
Picco, Natalia
Alustiza, Fabrisio Eduardo
Grosso, M. Carolina
Vivas, Adriana
Acevedo, Diego F.
Barbero, Cesar A.
author_role author
author2 Mulko, Lucinda
Molina, Maria
Picco, Natalia
Alustiza, Fabrisio Eduardo
Grosso, M. Carolina
Vivas, Adriana
Acevedo, Diego F.
Barbero, Cesar A.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Quitosano
Geles
Nanocompuestos
pH
Propiedades Antimicrobianas
Chitosan
Gels
Nanocomposites
Antimicrobial Properties
Hidrogeles
Propiedades Antibacterianas
Biomateriales
topic Quitosano
Geles
Nanocompuestos
pH
Propiedades Antimicrobianas
Chitosan
Gels
Nanocomposites
Antimicrobial Properties
Hidrogeles
Propiedades Antibacterianas
Biomateriales
dc.description.none.fl_txt_mv The present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes to acrylamide-co-acrylic acid hydrogels. The nanocomposites chemical structure was characterized by Fourier Transform Infrared Spectroscopy (FT-IR). The FT-IR shows the typical bands due to the hydrogel and additionally the peaks at 1750 cm−1 and 1450 cm−1 that correspond to the carbon nanotubes incorporated into the polymer matrix. Mechanical properties and swelling measurements in different buffer solutions were also performed. The nanocomposites showed improved mechanical properties and a stronger pH-response. In order to evaluate antimicrobial activity, the growth and adhesion of Staphylococcus aureus to nanocomposites were studied. Cytocompatibility was also evaluated by MTT assay on MDCK and 3T3 cell lines. The nanocomposites were found to be cytocompatible and showed a reduced bacterial colonization.
EEA Marcos Juárez
Fil: Bellingeri, Romina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina
Fil: Mulko, Lucinda. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina
Fil: Molina, Maria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina
Fil: Picco, Natalia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina
Fil: Alustiza, Fabrisio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina
Fil: Grosso, M. Carolina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina
Fil: Vivas, Adriana. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina
Fil: Acevedo, Diego F. Universidad Nacional de Río Cuarto. Facultad de Ingeniería. Departamento de Tecnología Química; Argentina
Fil: Barbero, Cesar A.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina
description The present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes to acrylamide-co-acrylic acid hydrogels. The nanocomposites chemical structure was characterized by Fourier Transform Infrared Spectroscopy (FT-IR). The FT-IR shows the typical bands due to the hydrogel and additionally the peaks at 1750 cm−1 and 1450 cm−1 that correspond to the carbon nanotubes incorporated into the polymer matrix. Mechanical properties and swelling measurements in different buffer solutions were also performed. The nanocomposites showed improved mechanical properties and a stronger pH-response. In order to evaluate antimicrobial activity, the growth and adhesion of Staphylococcus aureus to nanocomposites were studied. Cytocompatibility was also evaluated by MTT assay on MDCK and 3T3 cell lines. The nanocomposites were found to be cytocompatible and showed a reduced bacterial colonization.
publishDate 2018
dc.date.none.fl_str_mv 2018-07-10T16:52:02Z
2018-07-10T16:52:02Z
2018-09-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0928493117335361?via%3Dihub
http://hdl.handle.net/20.500.12123/2755
0928-4931
https://doi.org/10.1016/j.msec.2018.04.090
url https://www.sciencedirect.com/science/article/pii/S0928493117335361?via%3Dihub
http://hdl.handle.net/20.500.12123/2755
https://doi.org/10.1016/j.msec.2018.04.090
identifier_str_mv 0928-4931
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Materials Science and Engineering: C 90 : 461-467 (September 2018)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1842341356116115456
score 12.623145

Publicaciones similares