Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations

Autores
Auad, Jordana; Cerutti, Julieta; Cooper, Laura Gabriela; Camussone, Cecilia; Lozano, Natalia A.; Crespo, Francisco M.; Lozano, Alejandro
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.
EEA Rafaela
Fil: Auad, Jordana. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina
Fil: Cerutti, Julieta. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina
Fil: Cooper, Laura Gabriela. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina
Fil: Camussone, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Camussone, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Lozano, Natalia A. Universidad Católica de Córdoba. Facultad de Medicina. Cátedra de Inmunología; Argentina
Fil: Crespo, Francisco M.. Establecimiento Los Talas. Potrero de Garay, Córdoba; Argentina
Fil: Lozano, Alejandro. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina
Fil: Lozano, Alejandro. Universidad Católica de Córdoba. Facultad de Medicina. Cátedra de Inmunología; Argentina
Fuente
Austral Journal of Veterinary Sciences 50 (2) : 101–105. (2018)
Materia
Corynebacterium pseudotuberculosis
Goats
Immune Response
Pregnancy
Bacterins
Immunoglobulins
Caseous Lymphadenitis
Caprinos
Respuesta Inmunológica
Gestación
Bacterinas
Inmunoglobulina
Linfoadenitis Caseosa
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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oai_identifier_str oai:localhost:20.500.12123/14799
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network_name_str INTA Digital (INTA)
spelling Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulationsAuad, JordanaCerutti, JulietaCooper, Laura GabrielaCamussone, CeciliaLozano, Natalia A.Crespo, Francisco M.Lozano, AlejandroCorynebacterium pseudotuberculosisGoatsImmune ResponsePregnancyBacterinsImmunoglobulinsCaseous LymphadenitisCaprinosRespuesta InmunológicaGestaciónBacterinasInmunoglobulinaLinfoadenitis CaseosaCaseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.EEA RafaelaFil: Auad, Jordana. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; ArgentinaFil: Cerutti, Julieta. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; ArgentinaFil: Cooper, Laura Gabriela. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; ArgentinaFil: Camussone, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Camussone, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Lozano, Natalia A. Universidad Católica de Córdoba. Facultad de Medicina. Cátedra de Inmunología; ArgentinaFil: Crespo, Francisco M.. Establecimiento Los Talas. Potrero de Garay, Córdoba; ArgentinaFil: Lozano, Alejandro. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; ArgentinaFil: Lozano, Alejandro. Universidad Católica de Córdoba. Facultad de Medicina. Cátedra de Inmunología; ArgentinaFacultad de Ciencias Veterinarias, Universidad Austral de Chile2023-07-21T14:18:43Z2023-07-21T14:18:43Z2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/14799http://revistas.uach.cl/index.php/australjvs/article/view/29610719-80000719-8132https://doi.org/10.4067/S0719-81322018000200101Austral Journal of Veterinary Sciences 50 (2) : 101–105. (2018)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:46:01Zoai:localhost:20.500.12123/14799instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:46:01.722INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
spellingShingle Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
Auad, Jordana
Corynebacterium pseudotuberculosis
Goats
Immune Response
Pregnancy
Bacterins
Immunoglobulins
Caseous Lymphadenitis
Caprinos
Respuesta Inmunológica
Gestación
Bacterinas
Inmunoglobulina
Linfoadenitis Caseosa
title_short Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_full Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_fullStr Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_full_unstemmed Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_sort Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
dc.creator.none.fl_str_mv Auad, Jordana
Cerutti, Julieta
Cooper, Laura Gabriela
Camussone, Cecilia
Lozano, Natalia A.
Crespo, Francisco M.
Lozano, Alejandro
author Auad, Jordana
author_facet Auad, Jordana
Cerutti, Julieta
Cooper, Laura Gabriela
Camussone, Cecilia
Lozano, Natalia A.
Crespo, Francisco M.
Lozano, Alejandro
author_role author
author2 Cerutti, Julieta
Cooper, Laura Gabriela
Camussone, Cecilia
Lozano, Natalia A.
Crespo, Francisco M.
Lozano, Alejandro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Corynebacterium pseudotuberculosis
Goats
Immune Response
Pregnancy
Bacterins
Immunoglobulins
Caseous Lymphadenitis
Caprinos
Respuesta Inmunológica
Gestación
Bacterinas
Inmunoglobulina
Linfoadenitis Caseosa
topic Corynebacterium pseudotuberculosis
Goats
Immune Response
Pregnancy
Bacterins
Immunoglobulins
Caseous Lymphadenitis
Caprinos
Respuesta Inmunológica
Gestación
Bacterinas
Inmunoglobulina
Linfoadenitis Caseosa
dc.description.none.fl_txt_mv Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.
EEA Rafaela
Fil: Auad, Jordana. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina
Fil: Cerutti, Julieta. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina
Fil: Cooper, Laura Gabriela. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina
Fil: Camussone, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Camussone, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Lozano, Natalia A. Universidad Católica de Córdoba. Facultad de Medicina. Cátedra de Inmunología; Argentina
Fil: Crespo, Francisco M.. Establecimiento Los Talas. Potrero de Garay, Córdoba; Argentina
Fil: Lozano, Alejandro. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina
Fil: Lozano, Alejandro. Universidad Católica de Córdoba. Facultad de Medicina. Cátedra de Inmunología; Argentina
description Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.
publishDate 2018
dc.date.none.fl_str_mv 2018
2023-07-21T14:18:43Z
2023-07-21T14:18:43Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/14799
http://revistas.uach.cl/index.php/australjvs/article/view/2961
0719-8000
0719-8132
https://doi.org/10.4067/S0719-81322018000200101
url http://hdl.handle.net/20.500.12123/14799
http://revistas.uach.cl/index.php/australjvs/article/view/2961
https://doi.org/10.4067/S0719-81322018000200101
identifier_str_mv 0719-8000
0719-8132
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Facultad de Ciencias Veterinarias, Universidad Austral de Chile
publisher.none.fl_str_mv Facultad de Ciencias Veterinarias, Universidad Austral de Chile
dc.source.none.fl_str_mv Austral Journal of Veterinary Sciences 50 (2) : 101–105. (2018)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.559606

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