Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina

Autores
Avellaneda Cáceres, Agustín; Lee, Stephen T.; Ruiz, Alvaro Francisco; Sandoval, Gabriela Virginia; Colque Caro, Luis Adrián; Cook, Daniel; Aguirre Castro, Laura Sabrina; Uzal, Francisco A.; Micheloud, Juan Francisco
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Over a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy revealed moderate ascites; mildly enlarged, pale, mottled kidneys; and perirenal edema. Microscopically, there was hyperplasia of mesangial cells in the renal glomeruli, renal tubular epithelial necrosis, and hyaline casts and refractive crystals in cortical and medullary renal tubular lumens. Samples of M. maximus from the affected pasture contained elevated concentrations of soluble oxalate (3.71%). Our findings suggest that oxalate produced by M. maximus caused acute tubular injury. Our case highlights the critical need for monitoring oxalate levels in pastures and managing grazing practices, particularly under drought conditions, to prevent similar outbreaks in the future.
Instituto de Investigación Animal del Chaco Semiárido
Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Avellaneda-Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina
Fil: Avellaneda Cáceres, Agustín. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Cátedra Elementos de Reproducción y Sanidad Animal; Argentina
Fil: Lee, Stephen T. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos
Fil: Lee, Stephen T. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos
Fil: Ruiz, A.F. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Sandoval, Gabriela V. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sandoval, Gabriela V. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido; Argentina
Fil: Sandoval, Gabriela V. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina
Fil: Cook, Daniel. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos
Fil: Aguirre, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguirre, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina
Fil: Aguirre, Laura Sabrina. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Uzal, Francisco A. University of California–Davis. California Animal Health and Food Safety Laboratory System; Estados Unidos
Fil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina
Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fuente
Journal of Veterinary Diagnostic Investigation : 1-4 (First published online May 19, 2025)
Materia
Panicum maximum
Ganado Bovino
Oxalatos
Enfermedades Renales
Plantas Tóxicas
Argentina
Cattle
Oxalates
Kidney Diseases
Poisonous Plants
Megathyrsus maximus
Pasto Guinea
Guinea Grass
Nephropathy
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/22577
Acceder
id INTADig_8e11485ac8982d9764808a1cc127aa42
oai_identifier_str oai:localhost:20.500.12123/22577
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in ArgentinaAvellaneda Cáceres, AgustínLee, Stephen T.Ruiz, Alvaro FranciscoSandoval, Gabriela VirginiaColque Caro, Luis AdriánCook, DanielAguirre Castro, Laura SabrinaUzal, Francisco A.Micheloud, Juan FranciscoPanicum maximumGanado BovinoOxalatosEnfermedades RenalesPlantas TóxicasArgentinaCattleOxalatesKidney DiseasesPoisonous PlantsMegathyrsus maximusPasto GuineaGuinea GrassNephropathyOver a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy revealed moderate ascites; mildly enlarged, pale, mottled kidneys; and perirenal edema. Microscopically, there was hyperplasia of mesangial cells in the renal glomeruli, renal tubular epithelial necrosis, and hyaline casts and refractive crystals in cortical and medullary renal tubular lumens. Samples of M. maximus from the affected pasture contained elevated concentrations of soluble oxalate (3.71%). Our findings suggest that oxalate produced by M. maximus caused acute tubular injury. Our case highlights the critical need for monitoring oxalate levels in pastures and managing grazing practices, particularly under drought conditions, to prevent similar outbreaks in the future.Instituto de Investigación Animal del Chaco SemiáridoFil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Avellaneda-Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; ArgentinaFil: Avellaneda Cáceres, Agustín. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Cátedra Elementos de Reproducción y Sanidad Animal; ArgentinaFil: Lee, Stephen T. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados UnidosFil: Lee, Stephen T. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados UnidosFil: Ruiz, A.F. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaFil: Sandoval, Gabriela V. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sandoval, Gabriela V. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido; ArgentinaFil: Sandoval, Gabriela V. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaFil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; ArgentinaFil: Cook, Daniel. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados UnidosFil: Aguirre, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aguirre, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; ArgentinaFil: Aguirre, Laura Sabrina. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaFil: Uzal, Francisco A. University of California–Davis. California Animal Health and Food Safety Laboratory System; Estados UnidosFil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; ArgentinaFil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaSage Publishing2025-06-09T11:40:20Z2025-06-09T11:40:20Z2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/22577https://journals.sagepub.com/doi/10.1177/104063872513362651040-63871943-4936https://doi.org/10.1177/10406387251336265Journal of Veterinary Diagnostic Investigation : 1-4 (First published online May 19, 2025)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-23T11:19:34Zoai:localhost:20.500.12123/22577instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:19:34.657INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
title Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
spellingShingle Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
Avellaneda Cáceres, Agustín
Panicum maximum
Ganado Bovino
Oxalatos
Enfermedades Renales
Plantas Tóxicas
Argentina
Cattle
Oxalates
Kidney Diseases
Poisonous Plants
Megathyrsus maximus
Pasto Guinea
Guinea Grass
Nephropathy
title_short Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
title_full Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
title_fullStr Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
title_full_unstemmed Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
title_sort Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
dc.creator.none.fl_str_mv Avellaneda Cáceres, Agustín
Lee, Stephen T.
Ruiz, Alvaro Francisco
Sandoval, Gabriela Virginia
Colque Caro, Luis Adrián
Cook, Daniel
Aguirre Castro, Laura Sabrina
Uzal, Francisco A.
Micheloud, Juan Francisco
author Avellaneda Cáceres, Agustín
author_facet Avellaneda Cáceres, Agustín
Lee, Stephen T.
Ruiz, Alvaro Francisco
Sandoval, Gabriela Virginia
Colque Caro, Luis Adrián
Cook, Daniel
Aguirre Castro, Laura Sabrina
Uzal, Francisco A.
Micheloud, Juan Francisco
author_role author
author2 Lee, Stephen T.
Ruiz, Alvaro Francisco
Sandoval, Gabriela Virginia
Colque Caro, Luis Adrián
Cook, Daniel
Aguirre Castro, Laura Sabrina
Uzal, Francisco A.
Micheloud, Juan Francisco
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Panicum maximum
Ganado Bovino
Oxalatos
Enfermedades Renales
Plantas Tóxicas
Argentina
Cattle
Oxalates
Kidney Diseases
Poisonous Plants
Megathyrsus maximus
Pasto Guinea
Guinea Grass
Nephropathy
topic Panicum maximum
Ganado Bovino
Oxalatos
Enfermedades Renales
Plantas Tóxicas
Argentina
Cattle
Oxalates
Kidney Diseases
Poisonous Plants
Megathyrsus maximus
Pasto Guinea
Guinea Grass
Nephropathy
dc.description.none.fl_txt_mv Over a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy revealed moderate ascites; mildly enlarged, pale, mottled kidneys; and perirenal edema. Microscopically, there was hyperplasia of mesangial cells in the renal glomeruli, renal tubular epithelial necrosis, and hyaline casts and refractive crystals in cortical and medullary renal tubular lumens. Samples of M. maximus from the affected pasture contained elevated concentrations of soluble oxalate (3.71%). Our findings suggest that oxalate produced by M. maximus caused acute tubular injury. Our case highlights the critical need for monitoring oxalate levels in pastures and managing grazing practices, particularly under drought conditions, to prevent similar outbreaks in the future.
Instituto de Investigación Animal del Chaco Semiárido
Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Avellaneda-Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina
Fil: Avellaneda Cáceres, Agustín. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Cátedra Elementos de Reproducción y Sanidad Animal; Argentina
Fil: Lee, Stephen T. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos
Fil: Lee, Stephen T. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos
Fil: Ruiz, A.F. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Sandoval, Gabriela V. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sandoval, Gabriela V. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido; Argentina
Fil: Sandoval, Gabriela V. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina
Fil: Cook, Daniel. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos
Fil: Aguirre, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguirre, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina
Fil: Aguirre, Laura Sabrina. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Uzal, Francisco A. University of California–Davis. California Animal Health and Food Safety Laboratory System; Estados Unidos
Fil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina
Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
description Over a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy revealed moderate ascites; mildly enlarged, pale, mottled kidneys; and perirenal edema. Microscopically, there was hyperplasia of mesangial cells in the renal glomeruli, renal tubular epithelial necrosis, and hyaline casts and refractive crystals in cortical and medullary renal tubular lumens. Samples of M. maximus from the affected pasture contained elevated concentrations of soluble oxalate (3.71%). Our findings suggest that oxalate produced by M. maximus caused acute tubular injury. Our case highlights the critical need for monitoring oxalate levels in pastures and managing grazing practices, particularly under drought conditions, to prevent similar outbreaks in the future.
publishDate 2025
dc.date.none.fl_str_mv 2025-06-09T11:40:20Z
2025-06-09T11:40:20Z
2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/22577
https://journals.sagepub.com/doi/10.1177/10406387251336265
1040-6387
1943-4936
https://doi.org/10.1177/10406387251336265
url http://hdl.handle.net/20.500.12123/22577
https://journals.sagepub.com/doi/10.1177/10406387251336265
https://doi.org/10.1177/10406387251336265
identifier_str_mv 1040-6387
1943-4936
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sage Publishing
publisher.none.fl_str_mv Sage Publishing
dc.source.none.fl_str_mv Journal of Veterinary Diagnostic Investigation : 1-4 (First published online May 19, 2025)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1846787605455175680
score 12.982451

Publicaciones similares