Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case o...

Autores: Marcucci, Carolina; Rademacher, Marina; Kamecki, Fabiola; Pastore, Velentina; Bach, Hernán Gerónimo; Ricco, Rafael Alejandro; Wagner, Marcelo Luis; Knez, Damijan; Gobec, Stanislav; Colettis, Natalia; Mander, Mariel
Año de publicación: 2023
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax (Griseb.) Höck and V. effusa Griseb., on different AD-related biological targets. Of these anxiolytic, sedative and sleep-inducing valerians, V. carnosa proved the most promising and was assayed in vivo. All valerians inhibited acetylcholinesterase (IC50 between 1.08–12.69 mg/mL) and butyrylcholinesterase (IC50 between 0.0019–1.46 mg/mL). They also inhibited the aggregation of β-amyloid peptide, were able to chelate Fe2+ ions, and exhibited a direct relationship between antioxidant capacity and phenolic content. Moreover, V. carnosa was able to inhibit human monoamine oxidase A (IC50: 0.286 mg/mL (0.213–0.384)). A daily intake of aqueous V. carnosa extract by male Swiss mice (50 and 150 mg/kg/day) resulted in anxiolytic and antidepressant-like behavior and improved spatial memory. In addition, decreased AChE activity and oxidative stress markers were observed in treated mouse brains. Our studies contribute to the development of indigenous herbal medicines as therapeutic agents for AD.
Instituto de Recursos Biológicos
Fil: Marcucci, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina
Fil: Rademacher, Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina
Fil: Kamecki, Fabiola. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina
Fil: Pastore, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina
Fil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina
Fil: Ricco, Rafael. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmabotánica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Tecnología Farmaceutica y Biofarmacia; Argentina
Fil: Wagner, Marcelo L. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina
Fil: Knez, Damijan. University of Ljubljana; Faculty of Pharmacy, Slovenia.
Fil: Gobec, Stanislav. University of Ljubljana; Faculty of Pharmacy, Slovenia.
Fil: Colettis, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina
Fil: Marder, Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina
Fuente: Pharmaceuticals 16 (1) : 129 (January 2023)
Materia: Medicinal Plants
Acetylcholinesterase
Antioxidants
Monoamine Oxidase
Memory
Valeriana
Plantas Medicinales
Acetilcolinesterasa
Antioxidantes
Monoamina Oxidasa
Memoria
Argentina
Alzheimer´s Disease
B Amyloid Aggregation
Antidepressant
Enfermedad de Alzheimer
Agregación de Amiloide B
Antidepresivo
Nivel de accesibilidad: acceso abierto
Condiciones de uso: http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Institución: Instituto Nacional de Tecnología Agropecuaria
OAI Identificador: oai:localhost:20.500.12123/14322

Acceder

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spelling	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in miceMarcucci, CarolinaRademacher, MarinaKamecki, FabiolaPastore, VelentinaBach, Hernán GerónimoRicco, Rafael AlejandroWagner, Marcelo LuisKnez, DamijanGobec, StanislavColettis, NataliaMander, MarielMedicinal PlantsAcetylcholinesteraseAntioxidantsMonoamine OxidaseMemoryValerianaPlantas MedicinalesAcetilcolinesterasaAntioxidantesMonoamina OxidasaMemoriaArgentinaAlzheimer´s DiseaseB Amyloid AggregationAntidepressantEnfermedad de AlzheimerAgregación de Amiloide BAntidepresivoAlzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax (Griseb.) Höck and V. effusa Griseb., on different AD-related biological targets. Of these anxiolytic, sedative and sleep-inducing valerians, V. carnosa proved the most promising and was assayed in vivo. All valerians inhibited acetylcholinesterase (IC50 between 1.08–12.69 mg/mL) and butyrylcholinesterase (IC50 between 0.0019–1.46 mg/mL). They also inhibited the aggregation of β-amyloid peptide, were able to chelate Fe2+ ions, and exhibited a direct relationship between antioxidant capacity and phenolic content. Moreover, V. carnosa was able to inhibit human monoamine oxidase A (IC50: 0.286 mg/mL (0.213–0.384)). A daily intake of aqueous V. carnosa extract by male Swiss mice (50 and 150 mg/kg/day) resulted in anxiolytic and antidepressant-like behavior and improved spatial memory. In addition, decreased AChE activity and oxidative stress markers were observed in treated mouse brains. Our studies contribute to the development of indigenous herbal medicines as therapeutic agents for AD.Instituto de Recursos BiológicosFil: Marcucci, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; ArgentinaFil: Rademacher, Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; ArgentinaFil: Kamecki, Fabiola. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; ArgentinaFil: Pastore, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; ArgentinaFil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; ArgentinaFil: Ricco, Rafael. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmabotánica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Tecnología Farmaceutica y Biofarmacia; ArgentinaFil: Wagner, Marcelo L. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; ArgentinaFil: Knez, Damijan. University of Ljubljana; Faculty of Pharmacy, Slovenia.Fil: Gobec, Stanislav. University of Ljubljana; Faculty of Pharmacy, Slovenia.Fil: Colettis, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; ArgentinaFil: Marder, Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; ArgentinaMDPI2023-03-23T15:21:22Z2023-03-23T15:21:22Z2023-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/14322https://www.mdpi.com/1424-8247/16/1/1291424-8247https://doi.org/10.3390/ph16010129Pharmaceuticals 16 (1) : 129 (January 2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:49:46Zoai:localhost:20.500.12123/14322instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:49:47.106INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
title	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
spellingShingle	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice Marcucci, Carolina Medicinal Plants Acetylcholinesterase Antioxidants Monoamine Oxidase Memory Valeriana Plantas Medicinales Acetilcolinesterasa Antioxidantes Monoamina Oxidasa Memoria Argentina Alzheimer´s Disease B Amyloid Aggregation Antidepressant Enfermedad de Alzheimer Agregación de Amiloide B Antidepresivo
title_short	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
title_full	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
title_fullStr	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
title_full_unstemmed	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
title_sort	Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
dc.creator.none.fl_str_mv	Marcucci, Carolina Rademacher, Marina Kamecki, Fabiola Pastore, Velentina Bach, Hernán Gerónimo Ricco, Rafael Alejandro Wagner, Marcelo Luis Knez, Damijan Gobec, Stanislav Colettis, Natalia Mander, Mariel
author	Marcucci, Carolina
author_facet	Marcucci, Carolina Rademacher, Marina Kamecki, Fabiola Pastore, Velentina Bach, Hernán Gerónimo Ricco, Rafael Alejandro Wagner, Marcelo Luis Knez, Damijan Gobec, Stanislav Colettis, Natalia Mander, Mariel
author_role	author
author2	Rademacher, Marina Kamecki, Fabiola Pastore, Velentina Bach, Hernán Gerónimo Ricco, Rafael Alejandro Wagner, Marcelo Luis Knez, Damijan Gobec, Stanislav Colettis, Natalia Mander, Mariel
author2_role	author author author author author author author author author author
dc.subject.none.fl_str_mv	Medicinal Plants Acetylcholinesterase Antioxidants Monoamine Oxidase Memory Valeriana Plantas Medicinales Acetilcolinesterasa Antioxidantes Monoamina Oxidasa Memoria Argentina Alzheimer´s Disease B Amyloid Aggregation Antidepressant Enfermedad de Alzheimer Agregación de Amiloide B Antidepresivo
topic	Medicinal Plants Acetylcholinesterase Antioxidants Monoamine Oxidase Memory Valeriana Plantas Medicinales Acetilcolinesterasa Antioxidantes Monoamina Oxidasa Memoria Argentina Alzheimer´s Disease B Amyloid Aggregation Antidepressant Enfermedad de Alzheimer Agregación de Amiloide B Antidepresivo
dc.description.none.fl_txt_mv	Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax (Griseb.) Höck and V. effusa Griseb., on different AD-related biological targets. Of these anxiolytic, sedative and sleep-inducing valerians, V. carnosa proved the most promising and was assayed in vivo. All valerians inhibited acetylcholinesterase (IC50 between 1.08–12.69 mg/mL) and butyrylcholinesterase (IC50 between 0.0019–1.46 mg/mL). They also inhibited the aggregation of β-amyloid peptide, were able to chelate Fe2+ ions, and exhibited a direct relationship between antioxidant capacity and phenolic content. Moreover, V. carnosa was able to inhibit human monoamine oxidase A (IC50: 0.286 mg/mL (0.213–0.384)). A daily intake of aqueous V. carnosa extract by male Swiss mice (50 and 150 mg/kg/day) resulted in anxiolytic and antidepressant-like behavior and improved spatial memory. In addition, decreased AChE activity and oxidative stress markers were observed in treated mouse brains. Our studies contribute to the development of indigenous herbal medicines as therapeutic agents for AD. Instituto de Recursos Biológicos Fil: Marcucci, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Rademacher, Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Kamecki, Fabiola. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Pastore, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina Fil: Ricco, Rafael. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmabotánica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Tecnología Farmaceutica y Biofarmacia; Argentina Fil: Wagner, Marcelo L. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina Fil: Knez, Damijan. University of Ljubljana; Faculty of Pharmacy, Slovenia. Fil: Gobec, Stanislav. University of Ljubljana; Faculty of Pharmacy, Slovenia. Fil: Colettis, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Marder, Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina
description	Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax (Griseb.) Höck and V. effusa Griseb., on different AD-related biological targets. Of these anxiolytic, sedative and sleep-inducing valerians, V. carnosa proved the most promising and was assayed in vivo. All valerians inhibited acetylcholinesterase (IC50 between 1.08–12.69 mg/mL) and butyrylcholinesterase (IC50 between 0.0019–1.46 mg/mL). They also inhibited the aggregation of β-amyloid peptide, were able to chelate Fe2+ ions, and exhibited a direct relationship between antioxidant capacity and phenolic content. Moreover, V. carnosa was able to inhibit human monoamine oxidase A (IC50: 0.286 mg/mL (0.213–0.384)). A daily intake of aqueous V. carnosa extract by male Swiss mice (50 and 150 mg/kg/day) resulted in anxiolytic and antidepressant-like behavior and improved spatial memory. In addition, decreased AChE activity and oxidative stress markers were observed in treated mouse brains. Our studies contribute to the development of indigenous herbal medicines as therapeutic agents for AD.
publishDate	2023
dc.date.none.fl_str_mv	2023-03-23T15:21:22Z 2023-03-23T15:21:22Z 2023-01-01
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dc.language.none.fl_str_mv	eng
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dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Pharmaceuticals 16 (1) : 129 (January 2023) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria
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repository.mail.fl_str_mv	tripaldi.nicolas@inta.gob.ar
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Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case o...

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