Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species

Autores
Etchecopaz, Alenadro A.; Di Ciaccio, Lucia Soledad; Hermida Alava, Katherine; Fortunato, Reneé H.; Salvat, Adriana Elisabeth; Nusblat, Alejandro E.; Cuestas, Maria L.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abstract Infections caused by the genus Candida have acquired considerable significance in recent years due to the enhanced susceptibility of immunocompromised hosts. There have been increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal therapy. Accordingly, exploring and developing novel anti-Candida agents has become a priority. In this study, we assessed the antifungal activity of seven methanolic extracts from the Argentinian native plants Peltophorum dubium, Schinus areira, Parastrephia quadran gularis and Lantana balansae against clinical isolates of different wild-type and MDR isolates of Candida. Synergism with fluconazole was also evaluated. All plant extracts showed antifun gal activities against different Candida species, including MDR isolates such as C. haemulonii. Highly active extracts from these native plants provide promising sources of compounds for potentiating the antifungal effect of fluconazole. Further investigation of the chemical con stituents of the extracts and their cytotoxicity is needed to develop plant-derived anti-Candida agents.
Instituto de Patobiología
Fil: Etchecopaz, Alejandro A. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Etchecopaz, Alejandro A. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Etchecopaz, Alejandro A. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina
Fil: Di Ciaccio, Lucí­a Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Hermida Alava, Katherine. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Hermida Alava, Katherine. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Fortunato, Reneé H. Instituto de Botánica Darwinion; Argentina
Fil: Salvat, Adriana Elisabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Nusblat, Alejandro E. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Nanobiotecnología (NANOBIOTEC); Argentina
Fil: Nusblat, Alejandro E. Universidad de Buenos Aires (UBA). Instituto de Nanobiotecnología (NANOBIOTEC); Argentina
Fil: Cuestas, Maria L. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Cuestas, Maria L. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fuente
Revista Argentina de Microbiología 10:1016 (Julio 2025)
Materia
Planta Antifúngica
Propiedad Antimicosica
Resistencia a Medicamentos
Antifungal Plants
Antifungal Properties
Drug Resistance
Plantas Nativas Argentinas
Candida Sp.
Sinergismo
Argentinian Native Plants
Synergism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/24782
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oai_identifier_str oai:localhost:20.500.12123/24782
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network_name_str INTA Digital (INTA)
spelling Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida speciesEtchecopaz, Alenadro A.Di Ciaccio, Lucia SoledadHermida Alava, KatherineFortunato, Reneé H.Salvat, Adriana ElisabethNusblat, Alejandro E.Cuestas, Maria L.Planta AntifúngicaPropiedad AntimicosicaResistencia a MedicamentosAntifungal PlantsAntifungal PropertiesDrug ResistancePlantas Nativas ArgentinasCandida Sp.SinergismoArgentinian Native PlantsSynergismAbstract Infections caused by the genus Candida have acquired considerable significance in recent years due to the enhanced susceptibility of immunocompromised hosts. There have been increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal therapy. Accordingly, exploring and developing novel anti-Candida agents has become a priority. In this study, we assessed the antifungal activity of seven methanolic extracts from the Argentinian native plants Peltophorum dubium, Schinus areira, Parastrephia quadran gularis and Lantana balansae against clinical isolates of different wild-type and MDR isolates of Candida. Synergism with fluconazole was also evaluated. All plant extracts showed antifun gal activities against different Candida species, including MDR isolates such as C. haemulonii. Highly active extracts from these native plants provide promising sources of compounds for potentiating the antifungal effect of fluconazole. Further investigation of the chemical con stituents of the extracts and their cytotoxicity is needed to develop plant-derived anti-Candida agents.Instituto de PatobiologíaFil: Etchecopaz, Alejandro A. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); ArgentinaFil: Etchecopaz, Alejandro A. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); ArgentinaFil: Etchecopaz, Alejandro A. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; ArgentinaFil: Di Ciaccio, Lucí­a Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Hermida Alava, Katherine. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); ArgentinaFil: Hermida Alava, Katherine. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); ArgentinaFil: Fortunato, Reneé H. Instituto de Botánica Darwinion; ArgentinaFil: Salvat, Adriana Elisabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Nusblat, Alejandro E. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Nanobiotecnología (NANOBIOTEC); ArgentinaFil: Nusblat, Alejandro E. Universidad de Buenos Aires (UBA). Instituto de Nanobiotecnología (NANOBIOTEC); ArgentinaFil: Cuestas, Maria L. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); ArgentinaFil: Cuestas, Maria L. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); ArgentinaElsevier2025-12-26T23:09:33Z2025-12-26T23:09:33Z2025-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/24782https://www.elsevier.es/en-revista-revista-argentina-microbiologia-argentinean-372-pdf-S03257541250009020325-7541https://doi.org/10.1016/j.ram.2025.07.006Revista Argentina de Microbiología 10:1016 (Julio 2025)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2026-02-26T11:47:38Zoai:localhost:20.500.12123/24782instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2026-02-26 11:47:38.896INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
title Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
spellingShingle Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
Etchecopaz, Alenadro A.
Planta Antifúngica
Propiedad Antimicosica
Resistencia a Medicamentos
Antifungal Plants
Antifungal Properties
Drug Resistance
Plantas Nativas Argentinas
Candida Sp.
Sinergismo
Argentinian Native Plants
Synergism
title_short Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
title_full Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
title_fullStr Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
title_full_unstemmed Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
title_sort Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
dc.creator.none.fl_str_mv Etchecopaz, Alenadro A.
Di Ciaccio, Lucia Soledad
Hermida Alava, Katherine
Fortunato, Reneé H.
Salvat, Adriana Elisabeth
Nusblat, Alejandro E.
Cuestas, Maria L.
author Etchecopaz, Alenadro A.
author_facet Etchecopaz, Alenadro A.
Di Ciaccio, Lucia Soledad
Hermida Alava, Katherine
Fortunato, Reneé H.
Salvat, Adriana Elisabeth
Nusblat, Alejandro E.
Cuestas, Maria L.
author_role author
author2 Di Ciaccio, Lucia Soledad
Hermida Alava, Katherine
Fortunato, Reneé H.
Salvat, Adriana Elisabeth
Nusblat, Alejandro E.
Cuestas, Maria L.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Planta Antifúngica
Propiedad Antimicosica
Resistencia a Medicamentos
Antifungal Plants
Antifungal Properties
Drug Resistance
Plantas Nativas Argentinas
Candida Sp.
Sinergismo
Argentinian Native Plants
Synergism
topic Planta Antifúngica
Propiedad Antimicosica
Resistencia a Medicamentos
Antifungal Plants
Antifungal Properties
Drug Resistance
Plantas Nativas Argentinas
Candida Sp.
Sinergismo
Argentinian Native Plants
Synergism
dc.description.none.fl_txt_mv Abstract Infections caused by the genus Candida have acquired considerable significance in recent years due to the enhanced susceptibility of immunocompromised hosts. There have been increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal therapy. Accordingly, exploring and developing novel anti-Candida agents has become a priority. In this study, we assessed the antifungal activity of seven methanolic extracts from the Argentinian native plants Peltophorum dubium, Schinus areira, Parastrephia quadran gularis and Lantana balansae against clinical isolates of different wild-type and MDR isolates of Candida. Synergism with fluconazole was also evaluated. All plant extracts showed antifun gal activities against different Candida species, including MDR isolates such as C. haemulonii. Highly active extracts from these native plants provide promising sources of compounds for potentiating the antifungal effect of fluconazole. Further investigation of the chemical con stituents of the extracts and their cytotoxicity is needed to develop plant-derived anti-Candida agents.
Instituto de Patobiología
Fil: Etchecopaz, Alejandro A. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Etchecopaz, Alejandro A. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Etchecopaz, Alejandro A. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina
Fil: Di Ciaccio, Lucí­a Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Hermida Alava, Katherine. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Hermida Alava, Katherine. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Fortunato, Reneé H. Instituto de Botánica Darwinion; Argentina
Fil: Salvat, Adriana Elisabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Nusblat, Alejandro E. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Nanobiotecnología (NANOBIOTEC); Argentina
Fil: Nusblat, Alejandro E. Universidad de Buenos Aires (UBA). Instituto de Nanobiotecnología (NANOBIOTEC); Argentina
Fil: Cuestas, Maria L. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
Fil: Cuestas, Maria L. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina
description Abstract Infections caused by the genus Candida have acquired considerable significance in recent years due to the enhanced susceptibility of immunocompromised hosts. There have been increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal therapy. Accordingly, exploring and developing novel anti-Candida agents has become a priority. In this study, we assessed the antifungal activity of seven methanolic extracts from the Argentinian native plants Peltophorum dubium, Schinus areira, Parastrephia quadran gularis and Lantana balansae against clinical isolates of different wild-type and MDR isolates of Candida. Synergism with fluconazole was also evaluated. All plant extracts showed antifun gal activities against different Candida species, including MDR isolates such as C. haemulonii. Highly active extracts from these native plants provide promising sources of compounds for potentiating the antifungal effect of fluconazole. Further investigation of the chemical con stituents of the extracts and their cytotoxicity is needed to develop plant-derived anti-Candida agents.
publishDate 2025
dc.date.none.fl_str_mv 2025-12-26T23:09:33Z
2025-12-26T23:09:33Z
2025-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/24782
https://www.elsevier.es/en-revista-revista-argentina-microbiologia-argentinean-372-pdf-S0325754125000902
0325-7541
https://doi.org/10.1016/j.ram.2025.07.006
url http://hdl.handle.net/20.500.12123/24782
https://www.elsevier.es/en-revista-revista-argentina-microbiologia-argentinean-372-pdf-S0325754125000902
https://doi.org/10.1016/j.ram.2025.07.006
identifier_str_mv 0325-7541
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Revista Argentina de Microbiología 10:1016 (Julio 2025)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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