The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifol...

Autores
Nagahama, Nicolas; Gastaldi, Bruno; Clifford, Michael; Manifesto, Maria Marcela; Fortunato, Renee Hersilia
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Valeriana carnosa and V. clarionifolia stand out as principal elements in the indigenous pharmacopeias of Patagonia; however, their phytochemical characterization is unknown. This study constitutes the starting point of a general project that aims to characterize secondary metabolites in these species. The variability of phenolic compounds in root ethanolic extracts was analyzed and compared for thirteen populations of V. carnosa and two of V. clarionifolia from the south of Argentinean Patagonia. Phenolic content was quantified by the Folin-Ciocalteu method and the putative phenolic compound profiles were investigated using HPLC-UV-MS. Antioxidant activity was evaluated through 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. Total phenolic content values ranged from 5.6 to 16.6 mg GAE/g in V. carnosa and 7.3 to 9.7 mg GAE/g in V. clarionifolia. Antioxidant evaluation results evidenced that the percentage of neutralized DPPH varied between 26% and 85% in V. carnosa and 39% and 58% in V. clarionifolia. A positive correlation between total phenolic content and antioxidant activity (r = 0.90) was observed. In V. carnosa total phenolic content was not correlated with altitude or latitude (p > 0.05), and chemical variability seems to be associated with genetic variability and/or different growing habitats (microclimatic conditions). However, the presence of some specific phenolic compounds was associated with latitude. In V. carnosa and V. clarionifolia 15 and 10 phenolic compounds were tentatively identified, respectively, and several of these are reported to have beneficial attributes from a phytomedical viewpoint. This study contributes to the phytochemical characterization project of these two medicinal valerians from Patagonia.
EEA Esquel
Fil: Nagahama, Nicolas. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agroforestal Esquel; Argentina
Fil: Gastaldi, Bruno. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.
Fil: Gastaldi, Bruno. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales y Ciencias de la Salud. Laboratorio de Investigación de Plantas Aromáticas y Medicinales Nativas; Argentina.
Fil: Clifford, Michael. University of Surrey. School of Bioscience and Medicine; Reino Unidos. Monash University. Department of Nutrition, Dietetics and Food; Australia.
Fil: Manifesto, María Marcela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina.
Fil: Fortunato, Renee Hersilia. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.
Fil: Fortunato, Renee Hersilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina.
Fuente
AIMS Agriculture and Food 6 (1) : 106-124. (2021)
Materia
Antioxidantes
Extractos Vegetales
Variación Genética
Fenol
Plantas Medicinales
Valeriana
Antioxidants
Plant Extracts
Genetic Variation
Phenols
Medicinal Plants
Valeriana carnosa Sm
Valeriana clarionifolia Phil.
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/8469
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spelling The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)Nagahama, NicolasGastaldi, BrunoClifford, MichaelManifesto, Maria MarcelaFortunato, Renee HersiliaAntioxidantesExtractos VegetalesVariación GenéticaFenolPlantas MedicinalesValerianaAntioxidantsPlant ExtractsGenetic VariationPhenolsMedicinal PlantsValeriana carnosa SmValeriana clarionifolia Phil.Valeriana carnosa and V. clarionifolia stand out as principal elements in the indigenous pharmacopeias of Patagonia; however, their phytochemical characterization is unknown. This study constitutes the starting point of a general project that aims to characterize secondary metabolites in these species. The variability of phenolic compounds in root ethanolic extracts was analyzed and compared for thirteen populations of V. carnosa and two of V. clarionifolia from the south of Argentinean Patagonia. Phenolic content was quantified by the Folin-Ciocalteu method and the putative phenolic compound profiles were investigated using HPLC-UV-MS. Antioxidant activity was evaluated through 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. Total phenolic content values ranged from 5.6 to 16.6 mg GAE/g in V. carnosa and 7.3 to 9.7 mg GAE/g in V. clarionifolia. Antioxidant evaluation results evidenced that the percentage of neutralized DPPH varied between 26% and 85% in V. carnosa and 39% and 58% in V. clarionifolia. A positive correlation between total phenolic content and antioxidant activity (r = 0.90) was observed. In V. carnosa total phenolic content was not correlated with altitude or latitude (p > 0.05), and chemical variability seems to be associated with genetic variability and/or different growing habitats (microclimatic conditions). However, the presence of some specific phenolic compounds was associated with latitude. In V. carnosa and V. clarionifolia 15 and 10 phenolic compounds were tentatively identified, respectively, and several of these are reported to have beneficial attributes from a phytomedical viewpoint. This study contributes to the phytochemical characterization project of these two medicinal valerians from Patagonia.EEA EsquelFil: Nagahama, Nicolas. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agroforestal Esquel; ArgentinaFil: Gastaldi, Bruno. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.Fil: Gastaldi, Bruno. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales y Ciencias de la Salud. Laboratorio de Investigación de Plantas Aromáticas y Medicinales Nativas; Argentina.Fil: Clifford, Michael. University of Surrey. School of Bioscience and Medicine; Reino Unidos. Monash University. Department of Nutrition, Dietetics and Food; Australia.Fil: Manifesto, María Marcela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina.Fil: Fortunato, Renee Hersilia. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.Fil: Fortunato, Renee Hersilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina.AIMS Press2020-12-21T16:30:46Z2020-12-21T16:30:46Z2020-12-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/8469http://www.aimspress.com/article/doi/10.3934/agrfood.20210072471-2086https://doi.org/10.3934/agrfood.2021007AIMS Agriculture and Food 6 (1) : 106-124. (2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:45:05Zoai:localhost:20.500.12123/8469instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:06.223INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)
title The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)
spellingShingle The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)
Nagahama, Nicolas
Antioxidantes
Extractos Vegetales
Variación Genética
Fenol
Plantas Medicinales
Valeriana
Antioxidants
Plant Extracts
Genetic Variation
Phenols
Medicinal Plants
Valeriana carnosa Sm
Valeriana clarionifolia Phil.
title_short The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)
title_full The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)
title_fullStr The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)
title_full_unstemmed The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)
title_sort The influence of environmental variations on the phenolic compound profiles and antioxidant activity of two medicinal Patagonian valerians (Valeriana carnosa Sm. and V. clarionifolia Phil.)
dc.creator.none.fl_str_mv Nagahama, Nicolas
Gastaldi, Bruno
Clifford, Michael
Manifesto, Maria Marcela
Fortunato, Renee Hersilia
author Nagahama, Nicolas
author_facet Nagahama, Nicolas
Gastaldi, Bruno
Clifford, Michael
Manifesto, Maria Marcela
Fortunato, Renee Hersilia
author_role author
author2 Gastaldi, Bruno
Clifford, Michael
Manifesto, Maria Marcela
Fortunato, Renee Hersilia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Antioxidantes
Extractos Vegetales
Variación Genética
Fenol
Plantas Medicinales
Valeriana
Antioxidants
Plant Extracts
Genetic Variation
Phenols
Medicinal Plants
Valeriana carnosa Sm
Valeriana clarionifolia Phil.
topic Antioxidantes
Extractos Vegetales
Variación Genética
Fenol
Plantas Medicinales
Valeriana
Antioxidants
Plant Extracts
Genetic Variation
Phenols
Medicinal Plants
Valeriana carnosa Sm
Valeriana clarionifolia Phil.
dc.description.none.fl_txt_mv Valeriana carnosa and V. clarionifolia stand out as principal elements in the indigenous pharmacopeias of Patagonia; however, their phytochemical characterization is unknown. This study constitutes the starting point of a general project that aims to characterize secondary metabolites in these species. The variability of phenolic compounds in root ethanolic extracts was analyzed and compared for thirteen populations of V. carnosa and two of V. clarionifolia from the south of Argentinean Patagonia. Phenolic content was quantified by the Folin-Ciocalteu method and the putative phenolic compound profiles were investigated using HPLC-UV-MS. Antioxidant activity was evaluated through 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. Total phenolic content values ranged from 5.6 to 16.6 mg GAE/g in V. carnosa and 7.3 to 9.7 mg GAE/g in V. clarionifolia. Antioxidant evaluation results evidenced that the percentage of neutralized DPPH varied between 26% and 85% in V. carnosa and 39% and 58% in V. clarionifolia. A positive correlation between total phenolic content and antioxidant activity (r = 0.90) was observed. In V. carnosa total phenolic content was not correlated with altitude or latitude (p > 0.05), and chemical variability seems to be associated with genetic variability and/or different growing habitats (microclimatic conditions). However, the presence of some specific phenolic compounds was associated with latitude. In V. carnosa and V. clarionifolia 15 and 10 phenolic compounds were tentatively identified, respectively, and several of these are reported to have beneficial attributes from a phytomedical viewpoint. This study contributes to the phytochemical characterization project of these two medicinal valerians from Patagonia.
EEA Esquel
Fil: Nagahama, Nicolas. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agroforestal Esquel; Argentina
Fil: Gastaldi, Bruno. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.
Fil: Gastaldi, Bruno. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales y Ciencias de la Salud. Laboratorio de Investigación de Plantas Aromáticas y Medicinales Nativas; Argentina.
Fil: Clifford, Michael. University of Surrey. School of Bioscience and Medicine; Reino Unidos. Monash University. Department of Nutrition, Dietetics and Food; Australia.
Fil: Manifesto, María Marcela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina.
Fil: Fortunato, Renee Hersilia. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.
Fil: Fortunato, Renee Hersilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina.
description Valeriana carnosa and V. clarionifolia stand out as principal elements in the indigenous pharmacopeias of Patagonia; however, their phytochemical characterization is unknown. This study constitutes the starting point of a general project that aims to characterize secondary metabolites in these species. The variability of phenolic compounds in root ethanolic extracts was analyzed and compared for thirteen populations of V. carnosa and two of V. clarionifolia from the south of Argentinean Patagonia. Phenolic content was quantified by the Folin-Ciocalteu method and the putative phenolic compound profiles were investigated using HPLC-UV-MS. Antioxidant activity was evaluated through 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. Total phenolic content values ranged from 5.6 to 16.6 mg GAE/g in V. carnosa and 7.3 to 9.7 mg GAE/g in V. clarionifolia. Antioxidant evaluation results evidenced that the percentage of neutralized DPPH varied between 26% and 85% in V. carnosa and 39% and 58% in V. clarionifolia. A positive correlation between total phenolic content and antioxidant activity (r = 0.90) was observed. In V. carnosa total phenolic content was not correlated with altitude or latitude (p > 0.05), and chemical variability seems to be associated with genetic variability and/or different growing habitats (microclimatic conditions). However, the presence of some specific phenolic compounds was associated with latitude. In V. carnosa and V. clarionifolia 15 and 10 phenolic compounds were tentatively identified, respectively, and several of these are reported to have beneficial attributes from a phytomedical viewpoint. This study contributes to the phytochemical characterization project of these two medicinal valerians from Patagonia.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-21T16:30:46Z
2020-12-21T16:30:46Z
2020-12-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/8469
http://www.aimspress.com/article/doi/10.3934/agrfood.2021007
2471-2086
https://doi.org/10.3934/agrfood.2021007
url http://hdl.handle.net/20.500.12123/8469
http://www.aimspress.com/article/doi/10.3934/agrfood.2021007
https://doi.org/10.3934/agrfood.2021007
identifier_str_mv 2471-2086
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv AIMS Press
publisher.none.fl_str_mv AIMS Press
dc.source.none.fl_str_mv AIMS Agriculture and Food 6 (1) : 106-124. (2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.559606

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