Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies

Autores
Larroza, Marcela Patricia; Soler, Paula; Robles, Carlos Alejandro; Cabrera, Francisco Raúl; Ballent, Mariana; Lanusse, Carlos; Lifschitz, Adrian Luis
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aims of this study were to evaluate the efficacy of two injectable formulations of doramectin (DRM) against Psoroptes ovis in sheep infested under controlled experimental conditions and to characterize the DRM plasma disposition kinetics in the infested animals. To this end, sheep were experimentally infested with a P. ovis strain from a farm with a history of treatment failure, and then treated either with DRM 1% (traditional preparation) on days 0 and 7 or with DRM 3.15% (long-acting formulation) on day 0. The efficacy of each treatment was calculated by counting live mites in skin scrapings. Plasma samples were obtained from each animal and DRM concentrations were measured by HPLC. After the two doses of DRM 1%, the maximum efficacy (98.8%) was reached on day 28, whereas after the single dose of DRM 3.15%, the maximum efficacy (100%) was reached on day 35 and ratified on day 42. The longacting formulation allowed obtaining higher exposure and more sustained concentrations of DRM than the traditional preparation. Although both DRM formulations studied were effective according to international protocols, they did not reach 100% effectiveness in the time required for approved pharmaceutical products against sheep scab, according to Argentine regulations.
Estación Experimental Agropecuaria Bariloche
Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina
Fil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
Fil: Cabrera, Francisco Raúl. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
Fil: Ballent, Mariana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina
Fil: Lifschitz, Adrián Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina
Fuente
Experimental Parasitology 218 : Art:107998 (Noviembre 2020)
Materia
Psoroptes Ovis
Enfermedades de los Animales
Control de Enfermedades
Animal Diseases
Disease Control
DRM
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/8088
Acceder
id INTADig_78bcbf41efd87aba1b11c2d636a25d02
oai_identifier_str oai:localhost:20.500.12123/8088
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategiesLarroza, Marcela PatriciaSoler, PaulaRobles, Carlos AlejandroCabrera, Francisco RaúlBallent, MarianaLanusse, CarlosLifschitz, Adrian LuisPsoroptes OvisEnfermedades de los AnimalesControl de EnfermedadesAnimal DiseasesDisease ControlDRMThe aims of this study were to evaluate the efficacy of two injectable formulations of doramectin (DRM) against Psoroptes ovis in sheep infested under controlled experimental conditions and to characterize the DRM plasma disposition kinetics in the infested animals. To this end, sheep were experimentally infested with a P. ovis strain from a farm with a history of treatment failure, and then treated either with DRM 1% (traditional preparation) on days 0 and 7 or with DRM 3.15% (long-acting formulation) on day 0. The efficacy of each treatment was calculated by counting live mites in skin scrapings. Plasma samples were obtained from each animal and DRM concentrations were measured by HPLC. After the two doses of DRM 1%, the maximum efficacy (98.8%) was reached on day 28, whereas after the single dose of DRM 3.15%, the maximum efficacy (100%) was reached on day 35 and ratified on day 42. The longacting formulation allowed obtaining higher exposure and more sustained concentrations of DRM than the traditional preparation. Although both DRM formulations studied were effective according to international protocols, they did not reach 100% effectiveness in the time required for approved pharmaceutical products against sheep scab, according to Argentine regulations.Estación Experimental Agropecuaria BarilocheFil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; ArgentinaFil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; ArgentinaFil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; ArgentinaFil: Cabrera, Francisco Raúl. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; ArgentinaFil: Ballent, Mariana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; ArgentinaFil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; ArgentinaFil: Lifschitz, Adrián Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; ArgentinaElsevier2020-10-20T14:52:19Z2020-10-20T14:52:19Z2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/8088https://www.sciencedirect.com/science/article/abs/pii/S001448942030196X0014-4894https://doi.org/10.1016/j.exppara.2020.107998Experimental Parasitology 218 : Art:107998 (Noviembre 2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-23T11:17:24Zoai:localhost:20.500.12123/8088instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:17:24.392INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
title Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
spellingShingle Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
Larroza, Marcela Patricia
Psoroptes Ovis
Enfermedades de los Animales
Control de Enfermedades
Animal Diseases
Disease Control
DRM
title_short Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
title_full Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
title_fullStr Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
title_full_unstemmed Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
title_sort Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
dc.creator.none.fl_str_mv Larroza, Marcela Patricia
Soler, Paula
Robles, Carlos Alejandro
Cabrera, Francisco Raúl
Ballent, Mariana
Lanusse, Carlos
Lifschitz, Adrian Luis
author Larroza, Marcela Patricia
author_facet Larroza, Marcela Patricia
Soler, Paula
Robles, Carlos Alejandro
Cabrera, Francisco Raúl
Ballent, Mariana
Lanusse, Carlos
Lifschitz, Adrian Luis
author_role author
author2 Soler, Paula
Robles, Carlos Alejandro
Cabrera, Francisco Raúl
Ballent, Mariana
Lanusse, Carlos
Lifschitz, Adrian Luis
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Psoroptes Ovis
Enfermedades de los Animales
Control de Enfermedades
Animal Diseases
Disease Control
DRM
topic Psoroptes Ovis
Enfermedades de los Animales
Control de Enfermedades
Animal Diseases
Disease Control
DRM
dc.description.none.fl_txt_mv The aims of this study were to evaluate the efficacy of two injectable formulations of doramectin (DRM) against Psoroptes ovis in sheep infested under controlled experimental conditions and to characterize the DRM plasma disposition kinetics in the infested animals. To this end, sheep were experimentally infested with a P. ovis strain from a farm with a history of treatment failure, and then treated either with DRM 1% (traditional preparation) on days 0 and 7 or with DRM 3.15% (long-acting formulation) on day 0. The efficacy of each treatment was calculated by counting live mites in skin scrapings. Plasma samples were obtained from each animal and DRM concentrations were measured by HPLC. After the two doses of DRM 1%, the maximum efficacy (98.8%) was reached on day 28, whereas after the single dose of DRM 3.15%, the maximum efficacy (100%) was reached on day 35 and ratified on day 42. The longacting formulation allowed obtaining higher exposure and more sustained concentrations of DRM than the traditional preparation. Although both DRM formulations studied were effective according to international protocols, they did not reach 100% effectiveness in the time required for approved pharmaceutical products against sheep scab, according to Argentine regulations.
Estación Experimental Agropecuaria Bariloche
Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina
Fil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
Fil: Cabrera, Francisco Raúl. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
Fil: Ballent, Mariana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina
Fil: Lifschitz, Adrián Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina
description The aims of this study were to evaluate the efficacy of two injectable formulations of doramectin (DRM) against Psoroptes ovis in sheep infested under controlled experimental conditions and to characterize the DRM plasma disposition kinetics in the infested animals. To this end, sheep were experimentally infested with a P. ovis strain from a farm with a history of treatment failure, and then treated either with DRM 1% (traditional preparation) on days 0 and 7 or with DRM 3.15% (long-acting formulation) on day 0. The efficacy of each treatment was calculated by counting live mites in skin scrapings. Plasma samples were obtained from each animal and DRM concentrations were measured by HPLC. After the two doses of DRM 1%, the maximum efficacy (98.8%) was reached on day 28, whereas after the single dose of DRM 3.15%, the maximum efficacy (100%) was reached on day 35 and ratified on day 42. The longacting formulation allowed obtaining higher exposure and more sustained concentrations of DRM than the traditional preparation. Although both DRM formulations studied were effective according to international protocols, they did not reach 100% effectiveness in the time required for approved pharmaceutical products against sheep scab, according to Argentine regulations.
publishDate 2020
dc.date.none.fl_str_mv 2020-10-20T14:52:19Z
2020-10-20T14:52:19Z
2020-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/8088
https://www.sciencedirect.com/science/article/abs/pii/S001448942030196X
0014-4894
https://doi.org/10.1016/j.exppara.2020.107998
url http://hdl.handle.net/20.500.12123/8088
https://www.sciencedirect.com/science/article/abs/pii/S001448942030196X
https://doi.org/10.1016/j.exppara.2020.107998
identifier_str_mv 0014-4894
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Experimental Parasitology 218 : Art:107998 (Noviembre 2020)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.982451

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