Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity

Autores
Quattrocchi, Valeria; Molinari, Maria Paula; Langellotti, Cecilia Ana; Gnazzo, Victoria; Taboga, Oscar Alberto; Zamorano, Patricia Ines
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were vaccinated with a single dose of inactivated FMDV (iFMDV), iFMDV + Bv, Bv, or culture medium. Humoral and cellular immune responses were higher in animals immunized with iFMDV + Bv than in mice vaccinated with iFMDV alone. Animals receiving iFMDV + Bv had significantly lower viremia at 2, 4 and 7 dpv, than those immunized with iFMDV alone. In order to prolong the immune response, iFMDV oil vaccine was co-inoculated with Bv. Animals receiving iFMDV oil vaccine + Bv were protected two days earlier than those receiving the iFMDV oil vaccine alone. Both formulations protected until 14 dpv, the last day of the experiment. This is the first report in which Bv is used as an adjuvant in a FMDV vaccine.
Instituto de Virología
Fil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Molinari, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Langellotti, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gnazzo, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Taboga, Oscar Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Salvador; Argentina
Fuente
Vaccine 31 (24) : 2713-2718 (May 2013)
Materia
Virus Fiebre Aftosa
Ratón
Baculovirus
Inoculación
Vacuna
Inmunidad
Enfermedades de los Animales
Aphthovirus
Mice
Inoculation
Vaccines
Immunity
Animal Diseases
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/4312

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oai_identifier_str oai:localhost:20.500.12123/4312
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network_name_str INTA Digital (INTA)
spelling Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunityQuattrocchi, ValeriaMolinari, Maria PaulaLangellotti, Cecilia AnaGnazzo, VictoriaTaboga, Oscar AlbertoZamorano, Patricia InesVirus Fiebre AftosaRatónBaculovirusInoculaciónVacunaInmunidadEnfermedades de los AnimalesAphthovirusMiceInoculationVaccinesImmunityAnimal DiseasesBaculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were vaccinated with a single dose of inactivated FMDV (iFMDV), iFMDV + Bv, Bv, or culture medium. Humoral and cellular immune responses were higher in animals immunized with iFMDV + Bv than in mice vaccinated with iFMDV alone. Animals receiving iFMDV + Bv had significantly lower viremia at 2, 4 and 7 dpv, than those immunized with iFMDV alone. In order to prolong the immune response, iFMDV oil vaccine was co-inoculated with Bv. Animals receiving iFMDV oil vaccine + Bv were protected two days earlier than those receiving the iFMDV oil vaccine alone. Both formulations protected until 14 dpv, the last day of the experiment. This is the first report in which Bv is used as an adjuvant in a FMDV vaccine.Instituto de VirologíaFil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Molinari, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Langellotti, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gnazzo, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Taboga, Oscar Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Salvador; ArgentinaElsevier2019-01-22T15:42:12Z2019-01-22T15:42:12Z2013-05-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.sciencedirect.com/science/article/pii/S0264410X13004131http://hdl.handle.net/20.500.12123/43120264-410Xhttps://doi.org/10.1016/j.vaccine.2013.03.067Vaccine 31 (24) : 2713-2718 (May 2013)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-04T09:47:47Zoai:localhost:20.500.12123/4312instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:47:47.525INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
title Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
spellingShingle Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
Quattrocchi, Valeria
Virus Fiebre Aftosa
Ratón
Baculovirus
Inoculación
Vacuna
Inmunidad
Enfermedades de los Animales
Aphthovirus
Mice
Inoculation
Vaccines
Immunity
Animal Diseases
title_short Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
title_full Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
title_fullStr Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
title_full_unstemmed Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
title_sort Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
dc.creator.none.fl_str_mv Quattrocchi, Valeria
Molinari, Maria Paula
Langellotti, Cecilia Ana
Gnazzo, Victoria
Taboga, Oscar Alberto
Zamorano, Patricia Ines
author Quattrocchi, Valeria
author_facet Quattrocchi, Valeria
Molinari, Maria Paula
Langellotti, Cecilia Ana
Gnazzo, Victoria
Taboga, Oscar Alberto
Zamorano, Patricia Ines
author_role author
author2 Molinari, Maria Paula
Langellotti, Cecilia Ana
Gnazzo, Victoria
Taboga, Oscar Alberto
Zamorano, Patricia Ines
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Virus Fiebre Aftosa
Ratón
Baculovirus
Inoculación
Vacuna
Inmunidad
Enfermedades de los Animales
Aphthovirus
Mice
Inoculation
Vaccines
Immunity
Animal Diseases
topic Virus Fiebre Aftosa
Ratón
Baculovirus
Inoculación
Vacuna
Inmunidad
Enfermedades de los Animales
Aphthovirus
Mice
Inoculation
Vaccines
Immunity
Animal Diseases
dc.description.none.fl_txt_mv Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were vaccinated with a single dose of inactivated FMDV (iFMDV), iFMDV + Bv, Bv, or culture medium. Humoral and cellular immune responses were higher in animals immunized with iFMDV + Bv than in mice vaccinated with iFMDV alone. Animals receiving iFMDV + Bv had significantly lower viremia at 2, 4 and 7 dpv, than those immunized with iFMDV alone. In order to prolong the immune response, iFMDV oil vaccine was co-inoculated with Bv. Animals receiving iFMDV oil vaccine + Bv were protected two days earlier than those receiving the iFMDV oil vaccine alone. Both formulations protected until 14 dpv, the last day of the experiment. This is the first report in which Bv is used as an adjuvant in a FMDV vaccine.
Instituto de Virología
Fil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Molinari, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Langellotti, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gnazzo, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Taboga, Oscar Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Salvador; Argentina
description Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were vaccinated with a single dose of inactivated FMDV (iFMDV), iFMDV + Bv, Bv, or culture medium. Humoral and cellular immune responses were higher in animals immunized with iFMDV + Bv than in mice vaccinated with iFMDV alone. Animals receiving iFMDV + Bv had significantly lower viremia at 2, 4 and 7 dpv, than those immunized with iFMDV alone. In order to prolong the immune response, iFMDV oil vaccine was co-inoculated with Bv. Animals receiving iFMDV oil vaccine + Bv were protected two days earlier than those receiving the iFMDV oil vaccine alone. Both formulations protected until 14 dpv, the last day of the experiment. This is the first report in which Bv is used as an adjuvant in a FMDV vaccine.
publishDate 2013
dc.date.none.fl_str_mv 2013-05-31
2019-01-22T15:42:12Z
2019-01-22T15:42:12Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0264410X13004131
http://hdl.handle.net/20.500.12123/4312
0264-410X
https://doi.org/10.1016/j.vaccine.2013.03.067
url https://www.sciencedirect.com/science/article/pii/S0264410X13004131
http://hdl.handle.net/20.500.12123/4312
https://doi.org/10.1016/j.vaccine.2013.03.067
identifier_str_mv 0264-410X
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Vaccine 31 (24) : 2713-2718 (May 2013)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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