Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
- Autores
- Rojas, Dante Emanuel; Dervilly-Pinel, Gaud; Cesbron, Nora; Penot, Mylène; Sydor, Alexandre; Prévost, Stéphanie; Le Bizec, Bruno
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Besides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices. The present study focused on Bicalutamide, a non-steroidal SARM used in human treatment of non-metastatic prostate cancer because of its anti-androgenic activity exhibiting no anti-anabolic effects. To select the most appropriate matrix to be used for control purposes, different animalmatrices (urine and faeces) have been investigated and SARM metabolism studied to highlight relevant metabolites of such treatments and establish associated detection time windows. The aim of this work was thus to compare the urinary and faecal eliminations of bicalutamide in a calf, and investigate phase I and II metabolites. The results in both matrices showed that bicalutamide was very rapidly and mainly excreted under its free form. The concentration levels were observed as higher in faeces (ppm) than urine (ppb); although both matrices were assessed as suitable for residue control. The metabolites found were consistent with hydroxylation (phase I reaction) combined or not with glucuronidation and sulfation (phase II reactions)
Instituto de Tecnología de Alimentos
Fil: Sancho, Rojas, Dante Emanuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos, Argentina. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Dervilly-Pinel, Gaud. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Cesbron, Nora. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Penot, Mylène. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Sydor, Alexandre. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Prévost, Stéphanie. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Le Bizec, Bruno. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia. - Fuente
- Drug Testing and Analysis 9 (7) : 1017-1025 (July 2017)
- Materia
-
Andrógenos
Bovinae
Orina
Heces
Androgens
Urine
Faeces
Bicalutamide - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/4703
Ver los metadatos del registro completo
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Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faecesRojas, Dante EmanuelDervilly-Pinel, GaudCesbron, NoraPenot, MylèneSydor, AlexandrePrévost, StéphanieLe Bizec, BrunoAndrógenosBovinaeOrinaHecesAndrogensUrineFaecesBicalutamideBesides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices. The present study focused on Bicalutamide, a non-steroidal SARM used in human treatment of non-metastatic prostate cancer because of its anti-androgenic activity exhibiting no anti-anabolic effects. To select the most appropriate matrix to be used for control purposes, different animalmatrices (urine and faeces) have been investigated and SARM metabolism studied to highlight relevant metabolites of such treatments and establish associated detection time windows. The aim of this work was thus to compare the urinary and faecal eliminations of bicalutamide in a calf, and investigate phase I and II metabolites. The results in both matrices showed that bicalutamide was very rapidly and mainly excreted under its free form. The concentration levels were observed as higher in faeces (ppm) than urine (ppb); although both matrices were assessed as suitable for residue control. The metabolites found were consistent with hydroxylation (phase I reaction) combined or not with glucuronidation and sulfation (phase II reactions)Instituto de Tecnología de AlimentosFil: Sancho, Rojas, Dante Emanuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos, Argentina. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Dervilly-Pinel, Gaud. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Cesbron, Nora. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Penot, Mylène. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Sydor, Alexandre. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Prévost, Stéphanie. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Le Bizec, Bruno. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Wiley2019-03-22T11:55:02Z2019-03-22T11:55:02Z2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://onlinelibrary.wiley.com/doi/10.1002/dta.2113http://hdl.handle.net/20.500.12123/4703https://doi.org/10.1002/dta.2113Drug Testing and Analysis 9 (7) : 1017-1025 (July 2017)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:44:36Zoai:localhost:20.500.12123/4703instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:36.777INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces |
title |
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces |
spellingShingle |
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces Rojas, Dante Emanuel Andrógenos Bovinae Orina Heces Androgens Urine Faeces Bicalutamide |
title_short |
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces |
title_full |
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces |
title_fullStr |
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces |
title_full_unstemmed |
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces |
title_sort |
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces |
dc.creator.none.fl_str_mv |
Rojas, Dante Emanuel Dervilly-Pinel, Gaud Cesbron, Nora Penot, Mylène Sydor, Alexandre Prévost, Stéphanie Le Bizec, Bruno |
author |
Rojas, Dante Emanuel |
author_facet |
Rojas, Dante Emanuel Dervilly-Pinel, Gaud Cesbron, Nora Penot, Mylène Sydor, Alexandre Prévost, Stéphanie Le Bizec, Bruno |
author_role |
author |
author2 |
Dervilly-Pinel, Gaud Cesbron, Nora Penot, Mylène Sydor, Alexandre Prévost, Stéphanie Le Bizec, Bruno |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Andrógenos Bovinae Orina Heces Androgens Urine Faeces Bicalutamide |
topic |
Andrógenos Bovinae Orina Heces Androgens Urine Faeces Bicalutamide |
dc.description.none.fl_txt_mv |
Besides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices. The present study focused on Bicalutamide, a non-steroidal SARM used in human treatment of non-metastatic prostate cancer because of its anti-androgenic activity exhibiting no anti-anabolic effects. To select the most appropriate matrix to be used for control purposes, different animalmatrices (urine and faeces) have been investigated and SARM metabolism studied to highlight relevant metabolites of such treatments and establish associated detection time windows. The aim of this work was thus to compare the urinary and faecal eliminations of bicalutamide in a calf, and investigate phase I and II metabolites. The results in both matrices showed that bicalutamide was very rapidly and mainly excreted under its free form. The concentration levels were observed as higher in faeces (ppm) than urine (ppb); although both matrices were assessed as suitable for residue control. The metabolites found were consistent with hydroxylation (phase I reaction) combined or not with glucuronidation and sulfation (phase II reactions) Instituto de Tecnología de Alimentos Fil: Sancho, Rojas, Dante Emanuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos, Argentina. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia. Fil: Dervilly-Pinel, Gaud. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia. Fil: Cesbron, Nora. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia. Fil: Penot, Mylène. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia. Fil: Sydor, Alexandre. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia. Fil: Prévost, Stéphanie. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia. Fil: Le Bizec, Bruno. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia. |
description |
Besides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices. The present study focused on Bicalutamide, a non-steroidal SARM used in human treatment of non-metastatic prostate cancer because of its anti-androgenic activity exhibiting no anti-anabolic effects. To select the most appropriate matrix to be used for control purposes, different animalmatrices (urine and faeces) have been investigated and SARM metabolism studied to highlight relevant metabolites of such treatments and establish associated detection time windows. The aim of this work was thus to compare the urinary and faecal eliminations of bicalutamide in a calf, and investigate phase I and II metabolites. The results in both matrices showed that bicalutamide was very rapidly and mainly excreted under its free form. The concentration levels were observed as higher in faeces (ppm) than urine (ppb); although both matrices were assessed as suitable for residue control. The metabolites found were consistent with hydroxylation (phase I reaction) combined or not with glucuronidation and sulfation (phase II reactions) |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07 2019-03-22T11:55:02Z 2019-03-22T11:55:02Z |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://onlinelibrary.wiley.com/doi/10.1002/dta.2113 http://hdl.handle.net/20.500.12123/4703 https://doi.org/10.1002/dta.2113 |
url |
https://onlinelibrary.wiley.com/doi/10.1002/dta.2113 http://hdl.handle.net/20.500.12123/4703 https://doi.org/10.1002/dta.2113 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess |
eu_rights_str_mv |
restrictedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
Drug Testing and Analysis 9 (7) : 1017-1025 (July 2017) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
collection |
INTA Digital (INTA) |
instname_str |
Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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1844619131918221312 |
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12.559606 |