Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces

Autores
Rojas, Dante Emanuel; Dervilly-Pinel, Gaud; Cesbron, Nora; Penot, Mylène; Sydor, Alexandre; Prévost, Stéphanie; Le Bizec, Bruno
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Besides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices. The present study focused on Bicalutamide, a non-steroidal SARM used in human treatment of non-metastatic prostate cancer because of its anti-androgenic activity exhibiting no anti-anabolic effects. To select the most appropriate matrix to be used for control purposes, different animalmatrices (urine and faeces) have been investigated and SARM metabolism studied to highlight relevant metabolites of such treatments and establish associated detection time windows. The aim of this work was thus to compare the urinary and faecal eliminations of bicalutamide in a calf, and investigate phase I and II metabolites. The results in both matrices showed that bicalutamide was very rapidly and mainly excreted under its free form. The concentration levels were observed as higher in faeces (ppm) than urine (ppb); although both matrices were assessed as suitable for residue control. The metabolites found were consistent with hydroxylation (phase I reaction) combined or not with glucuronidation and sulfation (phase II reactions)
Instituto de Tecnología de Alimentos
Fil: Sancho, Rojas, Dante Emanuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos, Argentina. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Dervilly-Pinel, Gaud. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Cesbron, Nora. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Penot, Mylène. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Sydor, Alexandre. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Prévost, Stéphanie. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Le Bizec, Bruno. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fuente
Drug Testing and Analysis 9 (7) : 1017-1025 (July 2017)
Materia
Andrógenos
Bovinae
Orina
Heces
Androgens
Urine
Faeces
Bicalutamide
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faecesRojas, Dante EmanuelDervilly-Pinel, GaudCesbron, NoraPenot, MylèneSydor, AlexandrePrévost, StéphanieLe Bizec, BrunoAndrógenosBovinaeOrinaHecesAndrogensUrineFaecesBicalutamideBesides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices. The present study focused on Bicalutamide, a non-steroidal SARM used in human treatment of non-metastatic prostate cancer because of its anti-androgenic activity exhibiting no anti-anabolic effects. To select the most appropriate matrix to be used for control purposes, different animalmatrices (urine and faeces) have been investigated and SARM metabolism studied to highlight relevant metabolites of such treatments and establish associated detection time windows. The aim of this work was thus to compare the urinary and faecal eliminations of bicalutamide in a calf, and investigate phase I and II metabolites. The results in both matrices showed that bicalutamide was very rapidly and mainly excreted under its free form. The concentration levels were observed as higher in faeces (ppm) than urine (ppb); although both matrices were assessed as suitable for residue control. The metabolites found were consistent with hydroxylation (phase I reaction) combined or not with glucuronidation and sulfation (phase II reactions)Instituto de Tecnología de AlimentosFil: Sancho, Rojas, Dante Emanuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos, Argentina. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Dervilly-Pinel, Gaud. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Cesbron, Nora. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Penot, Mylène. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Sydor, Alexandre. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Prévost, Stéphanie. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Fil: Le Bizec, Bruno. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.Wiley2019-03-22T11:55:02Z2019-03-22T11:55:02Z2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://onlinelibrary.wiley.com/doi/10.1002/dta.2113http://hdl.handle.net/20.500.12123/4703https://doi.org/10.1002/dta.2113Drug Testing and Analysis 9 (7) : 1017-1025 (July 2017)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:44:36Zoai:localhost:20.500.12123/4703instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:36.777INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
title Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
spellingShingle Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
Rojas, Dante Emanuel
Andrógenos
Bovinae
Orina
Heces
Androgens
Urine
Faeces
Bicalutamide
title_short Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
title_full Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
title_fullStr Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
title_full_unstemmed Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
title_sort Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
dc.creator.none.fl_str_mv Rojas, Dante Emanuel
Dervilly-Pinel, Gaud
Cesbron, Nora
Penot, Mylène
Sydor, Alexandre
Prévost, Stéphanie
Le Bizec, Bruno
author Rojas, Dante Emanuel
author_facet Rojas, Dante Emanuel
Dervilly-Pinel, Gaud
Cesbron, Nora
Penot, Mylène
Sydor, Alexandre
Prévost, Stéphanie
Le Bizec, Bruno
author_role author
author2 Dervilly-Pinel, Gaud
Cesbron, Nora
Penot, Mylène
Sydor, Alexandre
Prévost, Stéphanie
Le Bizec, Bruno
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Andrógenos
Bovinae
Orina
Heces
Androgens
Urine
Faeces
Bicalutamide
topic Andrógenos
Bovinae
Orina
Heces
Androgens
Urine
Faeces
Bicalutamide
dc.description.none.fl_txt_mv Besides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices. The present study focused on Bicalutamide, a non-steroidal SARM used in human treatment of non-metastatic prostate cancer because of its anti-androgenic activity exhibiting no anti-anabolic effects. To select the most appropriate matrix to be used for control purposes, different animalmatrices (urine and faeces) have been investigated and SARM metabolism studied to highlight relevant metabolites of such treatments and establish associated detection time windows. The aim of this work was thus to compare the urinary and faecal eliminations of bicalutamide in a calf, and investigate phase I and II metabolites. The results in both matrices showed that bicalutamide was very rapidly and mainly excreted under its free form. The concentration levels were observed as higher in faeces (ppm) than urine (ppb); although both matrices were assessed as suitable for residue control. The metabolites found were consistent with hydroxylation (phase I reaction) combined or not with glucuronidation and sulfation (phase II reactions)
Instituto de Tecnología de Alimentos
Fil: Sancho, Rojas, Dante Emanuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos, Argentina. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Dervilly-Pinel, Gaud. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Cesbron, Nora. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Penot, Mylène. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Sydor, Alexandre. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Prévost, Stéphanie. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
Fil: Le Bizec, Bruno. LUNAM Université. Oniris, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments; Francia.
description Besides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices. The present study focused on Bicalutamide, a non-steroidal SARM used in human treatment of non-metastatic prostate cancer because of its anti-androgenic activity exhibiting no anti-anabolic effects. To select the most appropriate matrix to be used for control purposes, different animalmatrices (urine and faeces) have been investigated and SARM metabolism studied to highlight relevant metabolites of such treatments and establish associated detection time windows. The aim of this work was thus to compare the urinary and faecal eliminations of bicalutamide in a calf, and investigate phase I and II metabolites. The results in both matrices showed that bicalutamide was very rapidly and mainly excreted under its free form. The concentration levels were observed as higher in faeces (ppm) than urine (ppb); although both matrices were assessed as suitable for residue control. The metabolites found were consistent with hydroxylation (phase I reaction) combined or not with glucuronidation and sulfation (phase II reactions)
publishDate 2017
dc.date.none.fl_str_mv 2017-07
2019-03-22T11:55:02Z
2019-03-22T11:55:02Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://onlinelibrary.wiley.com/doi/10.1002/dta.2113
http://hdl.handle.net/20.500.12123/4703
https://doi.org/10.1002/dta.2113
url https://onlinelibrary.wiley.com/doi/10.1002/dta.2113
http://hdl.handle.net/20.500.12123/4703
https://doi.org/10.1002/dta.2113
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Drug Testing and Analysis 9 (7) : 1017-1025 (July 2017)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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