Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina

Autores
Dibarbora, Marina; Cappuccio, Javier Alejandro; Olivera, Valeria Soledad; Quiroga, Maria Alejandra; Machuca, Mariana; Perfumo, Carlos Juan; Pérez, Daniel R.; Pereda, Ariel Julian
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Influenza A viruses (IAV) are important pathogens responsible for economic losses in the swine industry and represent a threat to public health. In Argentina, clinical, pathological, and virological findings suggest that IAV infection is widespread among pig farms. In addition, several subtypes of IAV, such as pH1N1, H3N2, δ1H1N1, and δ2H1N2, have been reported. Objectives: To evaluate the infection patterns of influenza virus in nine pig farms in Argentina. Methods: Clinical, serological, pathological, and virological cross‐sectional studies were conducted. Results: Clinical and pathological results were characteristic of endemic influenza infection in eight of the nine farms studied. By rRT‐PCR, six of the nine farms were positive to influenza. Five IAV were obtained. Genome analysis determined that four of the isolations were pH1N1 and that the remaining one was a reassortant human origin H3N2 virus containing pandemic internal genes. Serological results showed that all farms were positive to influenza A antibodies. Moreover, the hemagglutination inhibition test showed that infection with viruses containing HA′s from different subtypes (pH1, δ1H1, δ2H1, and H3) is present among the farms studied and that coinfections with two or more subtypes were present in 80.5% of positive pigs. Conclusions: Because vaccines against IAV are not licensed in Argentina, these results reflect the situation of IAV infection in non‐vaccinated herds. This study provides more information about the circulation and characteristics of IAV in a poorly surveyed region. This study provides more data that will be used to evaluate the tools necessary to control this disease.
Instituto de Virología
Fil: Dibarbora, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Cappuccio, Javier Alejandro. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina
Fil: Quiroga, Maria Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
Fil: Machuca, Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
Fil: Perfumo, Carlos Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
Fil: Pérez, Daniel R. University of Maryland. Virginia‐Maryland Regional College of Veterinary Medicine. Department of Veterinary Medicine; Estados Unidos
Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fuente
Influenza and other respiratory viruses 7 (Suppl. 4) : 10–15. (December 2013)
Materia
Virus de la Influenza Porcina
Cerdo
Virus de los Animales
Inmunodiagnóstico
Enfermedades de los Animales
Swine
Animal Viruses
Immunodiagnosis
Animal Diseases
Swine Influenzavirus
Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/4673
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oai_identifier_str oai:localhost:20.500.12123/4673
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network_name_str INTA Digital (INTA)
spelling Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in ArgentinaDibarbora, MarinaCappuccio, Javier AlejandroOlivera, Valeria SoledadQuiroga, Maria AlejandraMachuca, MarianaPerfumo, Carlos JuanPérez, Daniel R.Pereda, Ariel JulianVirus de la Influenza PorcinaCerdoVirus de los AnimalesInmunodiagnósticoEnfermedades de los AnimalesSwineAnimal VirusesImmunodiagnosisAnimal DiseasesSwine InfluenzavirusArgentinaBackground: Influenza A viruses (IAV) are important pathogens responsible for economic losses in the swine industry and represent a threat to public health. In Argentina, clinical, pathological, and virological findings suggest that IAV infection is widespread among pig farms. In addition, several subtypes of IAV, such as pH1N1, H3N2, δ1H1N1, and δ2H1N2, have been reported. Objectives: To evaluate the infection patterns of influenza virus in nine pig farms in Argentina. Methods: Clinical, serological, pathological, and virological cross‐sectional studies were conducted. Results: Clinical and pathological results were characteristic of endemic influenza infection in eight of the nine farms studied. By rRT‐PCR, six of the nine farms were positive to influenza. Five IAV were obtained. Genome analysis determined that four of the isolations were pH1N1 and that the remaining one was a reassortant human origin H3N2 virus containing pandemic internal genes. Serological results showed that all farms were positive to influenza A antibodies. Moreover, the hemagglutination inhibition test showed that infection with viruses containing HA′s from different subtypes (pH1, δ1H1, δ2H1, and H3) is present among the farms studied and that coinfections with two or more subtypes were present in 80.5% of positive pigs. Conclusions: Because vaccines against IAV are not licensed in Argentina, these results reflect the situation of IAV infection in non‐vaccinated herds. This study provides more information about the circulation and characteristics of IAV in a poorly surveyed region. This study provides more data that will be used to evaluate the tools necessary to control this disease.Instituto de VirologíaFil: Dibarbora, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Cappuccio, Javier Alejandro. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; ArgentinaFil: Quiroga, Maria Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; ArgentinaFil: Machuca, Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; ArgentinaFil: Perfumo, Carlos Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; ArgentinaFil: Pérez, Daniel R. University of Maryland. Virginia‐Maryland Regional College of Veterinary Medicine. Department of Veterinary Medicine; Estados UnidosFil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaInternational Society for Influenza and other Respiratory Virus Diseases2019-03-20T12:13:22Z2019-03-20T12:13:22Z2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/46731750-2659 (Online)https://doi.org/10.1111/irv.12200Influenza and other respiratory viruses 7 (Suppl. 4) : 10–15. (December 2013)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-18T10:07:30Zoai:localhost:20.500.12123/4673instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-18 10:07:30.542INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina
title Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina
spellingShingle Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina
Dibarbora, Marina
Virus de la Influenza Porcina
Cerdo
Virus de los Animales
Inmunodiagnóstico
Enfermedades de los Animales
Swine
Animal Viruses
Immunodiagnosis
Animal Diseases
Swine Influenzavirus
Argentina
title_short Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina
title_full Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina
title_fullStr Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina
title_full_unstemmed Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina
title_sort Swine influenza: clinical, serological, pathological, and virological cross‐sectional studies in nine farms in Argentina
dc.creator.none.fl_str_mv Dibarbora, Marina
Cappuccio, Javier Alejandro
Olivera, Valeria Soledad
Quiroga, Maria Alejandra
Machuca, Mariana
Perfumo, Carlos Juan
Pérez, Daniel R.
Pereda, Ariel Julian
author Dibarbora, Marina
author_facet Dibarbora, Marina
Cappuccio, Javier Alejandro
Olivera, Valeria Soledad
Quiroga, Maria Alejandra
Machuca, Mariana
Perfumo, Carlos Juan
Pérez, Daniel R.
Pereda, Ariel Julian
author_role author
author2 Cappuccio, Javier Alejandro
Olivera, Valeria Soledad
Quiroga, Maria Alejandra
Machuca, Mariana
Perfumo, Carlos Juan
Pérez, Daniel R.
Pereda, Ariel Julian
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Virus de la Influenza Porcina
Cerdo
Virus de los Animales
Inmunodiagnóstico
Enfermedades de los Animales
Swine
Animal Viruses
Immunodiagnosis
Animal Diseases
Swine Influenzavirus
Argentina
topic Virus de la Influenza Porcina
Cerdo
Virus de los Animales
Inmunodiagnóstico
Enfermedades de los Animales
Swine
Animal Viruses
Immunodiagnosis
Animal Diseases
Swine Influenzavirus
Argentina
dc.description.none.fl_txt_mv Background: Influenza A viruses (IAV) are important pathogens responsible for economic losses in the swine industry and represent a threat to public health. In Argentina, clinical, pathological, and virological findings suggest that IAV infection is widespread among pig farms. In addition, several subtypes of IAV, such as pH1N1, H3N2, δ1H1N1, and δ2H1N2, have been reported. Objectives: To evaluate the infection patterns of influenza virus in nine pig farms in Argentina. Methods: Clinical, serological, pathological, and virological cross‐sectional studies were conducted. Results: Clinical and pathological results were characteristic of endemic influenza infection in eight of the nine farms studied. By rRT‐PCR, six of the nine farms were positive to influenza. Five IAV were obtained. Genome analysis determined that four of the isolations were pH1N1 and that the remaining one was a reassortant human origin H3N2 virus containing pandemic internal genes. Serological results showed that all farms were positive to influenza A antibodies. Moreover, the hemagglutination inhibition test showed that infection with viruses containing HA′s from different subtypes (pH1, δ1H1, δ2H1, and H3) is present among the farms studied and that coinfections with two or more subtypes were present in 80.5% of positive pigs. Conclusions: Because vaccines against IAV are not licensed in Argentina, these results reflect the situation of IAV infection in non‐vaccinated herds. This study provides more information about the circulation and characteristics of IAV in a poorly surveyed region. This study provides more data that will be used to evaluate the tools necessary to control this disease.
Instituto de Virología
Fil: Dibarbora, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Cappuccio, Javier Alejandro. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina
Fil: Quiroga, Maria Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
Fil: Machuca, Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
Fil: Perfumo, Carlos Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
Fil: Pérez, Daniel R. University of Maryland. Virginia‐Maryland Regional College of Veterinary Medicine. Department of Veterinary Medicine; Estados Unidos
Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
description Background: Influenza A viruses (IAV) are important pathogens responsible for economic losses in the swine industry and represent a threat to public health. In Argentina, clinical, pathological, and virological findings suggest that IAV infection is widespread among pig farms. In addition, several subtypes of IAV, such as pH1N1, H3N2, δ1H1N1, and δ2H1N2, have been reported. Objectives: To evaluate the infection patterns of influenza virus in nine pig farms in Argentina. Methods: Clinical, serological, pathological, and virological cross‐sectional studies were conducted. Results: Clinical and pathological results were characteristic of endemic influenza infection in eight of the nine farms studied. By rRT‐PCR, six of the nine farms were positive to influenza. Five IAV were obtained. Genome analysis determined that four of the isolations were pH1N1 and that the remaining one was a reassortant human origin H3N2 virus containing pandemic internal genes. Serological results showed that all farms were positive to influenza A antibodies. Moreover, the hemagglutination inhibition test showed that infection with viruses containing HA′s from different subtypes (pH1, δ1H1, δ2H1, and H3) is present among the farms studied and that coinfections with two or more subtypes were present in 80.5% of positive pigs. Conclusions: Because vaccines against IAV are not licensed in Argentina, these results reflect the situation of IAV infection in non‐vaccinated herds. This study provides more information about the circulation and characteristics of IAV in a poorly surveyed region. This study provides more data that will be used to evaluate the tools necessary to control this disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
2019-03-20T12:13:22Z
2019-03-20T12:13:22Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/4673
1750-2659 (Online)
https://doi.org/10.1111/irv.12200
url http://hdl.handle.net/20.500.12123/4673
https://doi.org/10.1111/irv.12200
identifier_str_mv 1750-2659 (Online)
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Society for Influenza and other Respiratory Virus Diseases
publisher.none.fl_str_mv International Society for Influenza and other Respiratory Virus Diseases
dc.source.none.fl_str_mv Influenza and other respiratory viruses 7 (Suppl. 4) : 10–15. (December 2013)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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