Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia

Autores
Martinez, Agustin; Cook, Daniel; Lee, Stephen T.; Sola, Diego; Bain, Luciana; Borrelli, Laura Beatriz; Acín, Cristina; Gardner, Dale R.; Robles, Carlos Alejandro
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina.
Estación Experimental Agropecuaria Bariloche
Fil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina
Fil: Cook, Daniel. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Lee, Stephen T. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Sola, Diego. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España
Fil: Bain, Luciana. Universidad Nacional del Centro de la Povincia de Buenos Aires; Argentina
Fil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; Argentina
Fil: Acín, Cristina. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España
Fil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
Fuente
Toxicon 186 : 191-197 (Octubre 2020)
Materia
Envenenamiento
Toxicidad por Ingestión
Festuca
Cabra
Caprinos
Enfermedades de los Animales
Poisoning
Ingestion Toxicity
Nannygoats
Goats
Animal Diseases
Región Patagónica
Festuca Argentina
Cabras Criollas
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/7765
Acceder
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oai_identifier_str oai:localhost:20.500.12123/7765
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine PatagoniaMartinez, AgustinCook, DanielLee, Stephen T.Sola, DiegoBain, LucianaBorrelli, Laura BeatrizAcín, CristinaGardner, Dale R.Robles, Carlos AlejandroEnvenenamientoToxicidad por IngestiónFestucaCabraCaprinosEnfermedades de los AnimalesPoisoningIngestion ToxicityNannygoatsGoatsAnimal DiseasesRegión PatagónicaFestuca ArgentinaCabras CriollasThe present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina.Estación Experimental Agropecuaria BarilocheFil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; ArgentinaFil: Cook, Daniel. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados UnidosFil: Lee, Stephen T. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados UnidosFil: Sola, Diego. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; EspañaFil: Bain, Luciana. Universidad Nacional del Centro de la Povincia de Buenos Aires; ArgentinaFil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; ArgentinaFil: Acín, Cristina. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; EspañaFil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados UnidosFil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; ArgentinaElsevier2020-08-25T11:37:08Z2020-08-25T11:37:08Z2020-10-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/7765https://www.sciencedirect.com/science/article/abs/pii/S00410101203034450041-0101https://doi.org/10.1016/j.toxicon.2020.08.004Toxicon 186 : 191-197 (Octubre 2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-23T11:17:21Zoai:localhost:20.500.12123/7765instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:17:21.821INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
title Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
spellingShingle Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
Martinez, Agustin
Envenenamiento
Toxicidad por Ingestión
Festuca
Cabra
Caprinos
Enfermedades de los Animales
Poisoning
Ingestion Toxicity
Nannygoats
Goats
Animal Diseases
Región Patagónica
Festuca Argentina
Cabras Criollas
title_short Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
title_full Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
title_fullStr Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
title_full_unstemmed Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
title_sort Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
dc.creator.none.fl_str_mv Martinez, Agustin
Cook, Daniel
Lee, Stephen T.
Sola, Diego
Bain, Luciana
Borrelli, Laura Beatriz
Acín, Cristina
Gardner, Dale R.
Robles, Carlos Alejandro
author Martinez, Agustin
author_facet Martinez, Agustin
Cook, Daniel
Lee, Stephen T.
Sola, Diego
Bain, Luciana
Borrelli, Laura Beatriz
Acín, Cristina
Gardner, Dale R.
Robles, Carlos Alejandro
author_role author
author2 Cook, Daniel
Lee, Stephen T.
Sola, Diego
Bain, Luciana
Borrelli, Laura Beatriz
Acín, Cristina
Gardner, Dale R.
Robles, Carlos Alejandro
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Envenenamiento
Toxicidad por Ingestión
Festuca
Cabra
Caprinos
Enfermedades de los Animales
Poisoning
Ingestion Toxicity
Nannygoats
Goats
Animal Diseases
Región Patagónica
Festuca Argentina
Cabras Criollas
topic Envenenamiento
Toxicidad por Ingestión
Festuca
Cabra
Caprinos
Enfermedades de los Animales
Poisoning
Ingestion Toxicity
Nannygoats
Goats
Animal Diseases
Región Patagónica
Festuca Argentina
Cabras Criollas
dc.description.none.fl_txt_mv The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina.
Estación Experimental Agropecuaria Bariloche
Fil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina
Fil: Cook, Daniel. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Lee, Stephen T. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Sola, Diego. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España
Fil: Bain, Luciana. Universidad Nacional del Centro de la Povincia de Buenos Aires; Argentina
Fil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; Argentina
Fil: Acín, Cristina. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España
Fil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
description The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-25T11:37:08Z
2020-08-25T11:37:08Z
2020-10-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/7765
https://www.sciencedirect.com/science/article/abs/pii/S0041010120303445
0041-0101
https://doi.org/10.1016/j.toxicon.2020.08.004
url http://hdl.handle.net/20.500.12123/7765
https://www.sciencedirect.com/science/article/abs/pii/S0041010120303445
https://doi.org/10.1016/j.toxicon.2020.08.004
identifier_str_mv 0041-0101
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Toxicon 186 : 191-197 (Octubre 2020)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.982451

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