Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
- Autores
- Martinez, Agustin; Cook, Daniel; Lee, Stephen T.; Sola, Diego; Bain, Luciana; Borrelli, Laura Beatriz; Acín, Cristina; Gardner, Dale R.; Robles, Carlos Alejandro
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina.
Estación Experimental Agropecuaria Bariloche
Fil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina
Fil: Cook, Daniel. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Lee, Stephen T. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Sola, Diego. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España
Fil: Bain, Luciana. Universidad Nacional del Centro de la Povincia de Buenos Aires; Argentina
Fil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; Argentina
Fil: Acín, Cristina. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España
Fil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina - Fuente
- Toxicon 186 : 191-197 (Octubre 2020)
- Materia
-
Envenenamiento
Toxicidad por Ingestión
Festuca
Cabra
Caprinos
Enfermedades de los Animales
Poisoning
Ingestion Toxicity
Nannygoats
Goats
Animal Diseases
Región Patagónica
Festuca Argentina
Cabras Criollas - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/7765
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Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine PatagoniaMartinez, AgustinCook, DanielLee, Stephen T.Sola, DiegoBain, LucianaBorrelli, Laura BeatrizAcín, CristinaGardner, Dale R.Robles, Carlos AlejandroEnvenenamientoToxicidad por IngestiónFestucaCabraCaprinosEnfermedades de los AnimalesPoisoningIngestion ToxicityNannygoatsGoatsAnimal DiseasesRegión PatagónicaFestuca ArgentinaCabras CriollasThe present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina.Estación Experimental Agropecuaria BarilocheFil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; ArgentinaFil: Cook, Daniel. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados UnidosFil: Lee, Stephen T. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados UnidosFil: Sola, Diego. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; EspañaFil: Bain, Luciana. Universidad Nacional del Centro de la Povincia de Buenos Aires; ArgentinaFil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; ArgentinaFil: Acín, Cristina. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; EspañaFil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados UnidosFil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; ArgentinaElsevier2020-08-25T11:37:08Z2020-08-25T11:37:08Z2020-10-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/7765https://www.sciencedirect.com/science/article/abs/pii/S00410101203034450041-0101https://doi.org/10.1016/j.toxicon.2020.08.004Toxicon 186 : 191-197 (Octubre 2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:45:00Zoai:localhost:20.500.12123/7765instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:00.899INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
title |
Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
spellingShingle |
Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia Martinez, Agustin Envenenamiento Toxicidad por Ingestión Festuca Cabra Caprinos Enfermedades de los Animales Poisoning Ingestion Toxicity Nannygoats Goats Animal Diseases Región Patagónica Festuca Argentina Cabras Criollas |
title_short |
Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
title_full |
Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
title_fullStr |
Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
title_full_unstemmed |
Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
title_sort |
Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
dc.creator.none.fl_str_mv |
Martinez, Agustin Cook, Daniel Lee, Stephen T. Sola, Diego Bain, Luciana Borrelli, Laura Beatriz Acín, Cristina Gardner, Dale R. Robles, Carlos Alejandro |
author |
Martinez, Agustin |
author_facet |
Martinez, Agustin Cook, Daniel Lee, Stephen T. Sola, Diego Bain, Luciana Borrelli, Laura Beatriz Acín, Cristina Gardner, Dale R. Robles, Carlos Alejandro |
author_role |
author |
author2 |
Cook, Daniel Lee, Stephen T. Sola, Diego Bain, Luciana Borrelli, Laura Beatriz Acín, Cristina Gardner, Dale R. Robles, Carlos Alejandro |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Envenenamiento Toxicidad por Ingestión Festuca Cabra Caprinos Enfermedades de los Animales Poisoning Ingestion Toxicity Nannygoats Goats Animal Diseases Región Patagónica Festuca Argentina Cabras Criollas |
topic |
Envenenamiento Toxicidad por Ingestión Festuca Cabra Caprinos Enfermedades de los Animales Poisoning Ingestion Toxicity Nannygoats Goats Animal Diseases Región Patagónica Festuca Argentina Cabras Criollas |
dc.description.none.fl_txt_mv |
The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina. Estación Experimental Agropecuaria Bariloche Fil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina Fil: Cook, Daniel. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos Fil: Lee, Stephen T. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos Fil: Sola, Diego. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España Fil: Bain, Luciana. Universidad Nacional del Centro de la Povincia de Buenos Aires; Argentina Fil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; Argentina Fil: Acín, Cristina. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España Fil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina |
description |
The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-25T11:37:08Z 2020-08-25T11:37:08Z 2020-10-30 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/7765 https://www.sciencedirect.com/science/article/abs/pii/S0041010120303445 0041-0101 https://doi.org/10.1016/j.toxicon.2020.08.004 |
url |
http://hdl.handle.net/20.500.12123/7765 https://www.sciencedirect.com/science/article/abs/pii/S0041010120303445 https://doi.org/10.1016/j.toxicon.2020.08.004 |
identifier_str_mv |
0041-0101 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess |
eu_rights_str_mv |
restrictedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
Toxicon 186 : 191-197 (Octubre 2020) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
collection |
INTA Digital (INTA) |
instname_str |
Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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12.559606 |