Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports

Autores: Martinez, Agustin; Apostolo, Romina Maria; Herrera, Rodolfo; Gardner, Dale; Borrelli, Laura Beatriz; Zabaleta, Gabriela; Robles, Carlos Alejandro; Ferrería, Joaquin
Año de publicación: 2024
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Otros proyectos vinculados: Sistema Regional de Salud Animal (SIRSA) INTA Bariloche - ANPCyT PICT # 2020-01484.
Two outbreaks of pine needle abortions in cattle are here reported for the first time in Argentina. The cases occurred in Chubut and Neuqu´en provinces in the Patagonia region, causing 29.6% and 9% of abortions in each herd respectively. In both outbreaks, the dams were in the last third of gestation, and, due to a period of cold, snow and lack of available forage, they gained access to Pinus ponderosa and Pinus contorta forests. No pathological lesions, serological, molecular, or microbiological evidence of infectious causes were observed in any of the six fetuses analyzed. Microhistological analysis of feces confirmed higher presence of fragments of Pinus spp. needles in the diet of affected dams than in that of non-affected ones (12.2 vs 3.0%). Moreover, toxicological analysis showed higher tetrahydroagathic acid in the sera of affected dams than in that of non-affected ones (10.05 vs 2.81 ppm). In addition, this acid was detected in different fetal fluids (3.6–8.1 ppm) of the six fetuses analyzed. Interestingly, isocupressic acid was detected only in needles of P. ponderosa, and its content was lower than that found in other areas of the world (0.31 and 0.5% in Chubut and Neuquén respectively). These results confirm that the consumption of P. ponderosa by dams could have been the cause of these abortion outbreaks, a fact that should be considered as differential diagnosis in abortions of cattle, especially in silvopastoral systems of Argentina.
EEA Bariloche
Fil: Martínez, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; Argentina
Fil: Apóstolo, Romina María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agroforestal Esquel; Argentina
Fil: Herrera, Rodolfo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; Argentina
Fil: Gardner, Dale. Laboratorio de Investigación de Plantas Venenosas Logan; Estados Unidos
Fil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; Argentina
Fil: Zabaleta, Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; Argentina
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; Argentina
Fil: Ferrería, Joaquin. Médico veterinario independiente; Argentina
Fuente: Toxicon 242 : 107712. (May 2024)
Materia: Pinus
Silvopastoral Systems
Cattle
Poisoning
Abortion
Sistemas Silvopascícolas
Ganado Bovino
Envenenamiento
Aborto
Argentina
Pinus ponderosa
Nivel de accesibilidad: acceso restringido
Condiciones de uso: http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Institución: Instituto Nacional de Tecnología Agropecuaria
OAI Identificador: oai:localhost:20.500.12123/21316

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spelling	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reportsAbortos en agujas de pino en bovinos por consumo de pinus ponderosa en Argentina: reporte de casosMartinez, AgustinApostolo, Romina MariaHerrera, RodolfoGardner, DaleBorrelli, Laura BeatrizZabaleta, GabrielaRobles, Carlos AlejandroFerrería, JoaquinPinusSilvopastoral SystemsCattlePoisoningAbortionSistemas SilvopascícolasGanado BovinoEnvenenamientoAbortoArgentinaPinus ponderosaOtros proyectos vinculados: Sistema Regional de Salud Animal (SIRSA) INTA Bariloche - ANPCyT PICT # 2020-01484.Two outbreaks of pine needle abortions in cattle are here reported for the first time in Argentina. The cases occurred in Chubut and Neuqu´en provinces in the Patagonia region, causing 29.6% and 9% of abortions in each herd respectively. In both outbreaks, the dams were in the last third of gestation, and, due to a period of cold, snow and lack of available forage, they gained access to Pinus ponderosa and Pinus contorta forests. No pathological lesions, serological, molecular, or microbiological evidence of infectious causes were observed in any of the six fetuses analyzed. Microhistological analysis of feces confirmed higher presence of fragments of Pinus spp. needles in the diet of affected dams than in that of non-affected ones (12.2 vs 3.0%). Moreover, toxicological analysis showed higher tetrahydroagathic acid in the sera of affected dams than in that of non-affected ones (10.05 vs 2.81 ppm). In addition, this acid was detected in different fetal fluids (3.6–8.1 ppm) of the six fetuses analyzed. Interestingly, isocupressic acid was detected only in needles of P. ponderosa, and its content was lower than that found in other areas of the world (0.31 and 0.5% in Chubut and Neuquén respectively). These results confirm that the consumption of P. ponderosa by dams could have been the cause of these abortion outbreaks, a fact that should be considered as differential diagnosis in abortions of cattle, especially in silvopastoral systems of Argentina.EEA BarilocheFil: Martínez, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; ArgentinaFil: Apóstolo, Romina María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agroforestal Esquel; ArgentinaFil: Herrera, Rodolfo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; ArgentinaFil: Gardner, Dale. Laboratorio de Investigación de Plantas Venenosas Logan; Estados UnidosFil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; ArgentinaFil: Zabaleta, Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; ArgentinaFil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; ArgentinaFil: Ferrería, Joaquin. Médico veterinario independiente; ArgentinaElsevier2025-02-18T10:31:17Z2025-02-18T10:31:17Z2024-04-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/21316https://www.sciencedirect.com/science/article/abs/pii/S0041010124002848A. Martinez, R. Apostolo, R. Herrera, D. Gardner, L. Borrelli, G. Zabaleta, C. Robles, J. Ferrería. Pine needle abortions in cattle due to consumption of Pinus ponderosa in Argentina: Case reports, Toxicon, Volume 242, 2024, 107712, ISSN 0041-0101, https://doi.org/10.1016/j.toxicon.2024.107712. (https://www.sciencedirect.com/science/article/pii/S0041010124002848)0041-01011879-3150 (en línea)https://doi.org/10.1016/j.toxicon.2024.107712Toxicon 242 : 107712. (May 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2023-PE-L01-I037, Desarrollo de sistemas de producción ganaderos climáticamente inteligentes para la Norpatagoniainfo:eu-repograntAgreement/INTA/2023-PE-L01-I067, Mejoramiento genético y silvicultura de plantaciones para la producción sostenible de productos forestales para distintos destinos industrialesinfo:eu-repograntAgreement/INTA/2019-RIST-E5-I111-001, Laboratorios de Diagnóstico VeterinarioArgentina .......... (nation) (World, South America)7006477info:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:47:09Zoai:localhost:20.500.12123/21316instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:47:09.369INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports Abortos en agujas de pino en bovinos por consumo de pinus ponderosa en Argentina: reporte de casos
title	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports
spellingShingle	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports Martinez, Agustin Pinus Silvopastoral Systems Cattle Poisoning Abortion Sistemas Silvopascícolas Ganado Bovino Envenenamiento Aborto Argentina Pinus ponderosa
title_short	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports
title_full	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports
title_fullStr	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports
title_full_unstemmed	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports
title_sort	Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports
dc.creator.none.fl_str_mv	Martinez, Agustin Apostolo, Romina Maria Herrera, Rodolfo Gardner, Dale Borrelli, Laura Beatriz Zabaleta, Gabriela Robles, Carlos Alejandro Ferrería, Joaquin
author	Martinez, Agustin
author_facet	Martinez, Agustin Apostolo, Romina Maria Herrera, Rodolfo Gardner, Dale Borrelli, Laura Beatriz Zabaleta, Gabriela Robles, Carlos Alejandro Ferrería, Joaquin
author_role	author
author2	Apostolo, Romina Maria Herrera, Rodolfo Gardner, Dale Borrelli, Laura Beatriz Zabaleta, Gabriela Robles, Carlos Alejandro Ferrería, Joaquin
author2_role	author author author author author author author
dc.subject.none.fl_str_mv	Pinus Silvopastoral Systems Cattle Poisoning Abortion Sistemas Silvopascícolas Ganado Bovino Envenenamiento Aborto Argentina Pinus ponderosa
topic	Pinus Silvopastoral Systems Cattle Poisoning Abortion Sistemas Silvopascícolas Ganado Bovino Envenenamiento Aborto Argentina Pinus ponderosa
dc.description.none.fl_txt_mv	Otros proyectos vinculados: Sistema Regional de Salud Animal (SIRSA) INTA Bariloche - ANPCyT PICT # 2020-01484. Two outbreaks of pine needle abortions in cattle are here reported for the first time in Argentina. The cases occurred in Chubut and Neuqu´en provinces in the Patagonia region, causing 29.6% and 9% of abortions in each herd respectively. In both outbreaks, the dams were in the last third of gestation, and, due to a period of cold, snow and lack of available forage, they gained access to Pinus ponderosa and Pinus contorta forests. No pathological lesions, serological, molecular, or microbiological evidence of infectious causes were observed in any of the six fetuses analyzed. Microhistological analysis of feces confirmed higher presence of fragments of Pinus spp. needles in the diet of affected dams than in that of non-affected ones (12.2 vs 3.0%). Moreover, toxicological analysis showed higher tetrahydroagathic acid in the sera of affected dams than in that of non-affected ones (10.05 vs 2.81 ppm). In addition, this acid was detected in different fetal fluids (3.6–8.1 ppm) of the six fetuses analyzed. Interestingly, isocupressic acid was detected only in needles of P. ponderosa, and its content was lower than that found in other areas of the world (0.31 and 0.5% in Chubut and Neuquén respectively). These results confirm that the consumption of P. ponderosa by dams could have been the cause of these abortion outbreaks, a fact that should be considered as differential diagnosis in abortions of cattle, especially in silvopastoral systems of Argentina. EEA Bariloche Fil: Martínez, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; Argentina Fil: Apóstolo, Romina María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agroforestal Esquel; Argentina Fil: Herrera, Rodolfo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; Argentina Fil: Gardner, Dale. Laboratorio de Investigación de Plantas Venenosas Logan; Estados Unidos Fil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; Argentina Fil: Zabaleta, Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; Argentina Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área de Producción Animal. Grupo Salud Animal; Argentina Fil: Ferrería, Joaquin. Médico veterinario independiente; Argentina
description	Otros proyectos vinculados: Sistema Regional de Salud Animal (SIRSA) INTA Bariloche - ANPCyT PICT # 2020-01484.
publishDate	2024
dc.date.none.fl_str_mv	2024-04-11 2025-02-18T10:31:17Z 2025-02-18T10:31:17Z
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12123/21316 https://www.sciencedirect.com/science/article/abs/pii/S0041010124002848 A. Martinez, R. Apostolo, R. Herrera, D. Gardner, L. Borrelli, G. Zabaleta, C. Robles, J. Ferrería. Pine needle abortions in cattle due to consumption of Pinus ponderosa in Argentina: Case reports, Toxicon, Volume 242, 2024, 107712, ISSN 0041-0101, https://doi.org/10.1016/j.toxicon.2024.107712. (https://www.sciencedirect.com/science/article/pii/S0041010124002848) 0041-0101 1879-3150 (en línea) https://doi.org/10.1016/j.toxicon.2024.107712
url	http://hdl.handle.net/20.500.12123/21316 https://www.sciencedirect.com/science/article/abs/pii/S0041010124002848 https://doi.org/10.1016/j.toxicon.2024.107712
identifier_str_mv	A. Martinez, R. Apostolo, R. Herrera, D. Gardner, L. Borrelli, G. Zabaleta, C. Robles, J. Ferrería. Pine needle abortions in cattle due to consumption of Pinus ponderosa in Argentina: Case reports, Toxicon, Volume 242, 2024, 107712, ISSN 0041-0101, https://doi.org/10.1016/j.toxicon.2024.107712. (https://www.sciencedirect.com/science/article/pii/S0041010124002848) 0041-0101 1879-3150 (en línea)
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repograntAgreement/INTA/2023-PE-L01-I037, Desarrollo de sistemas de producción ganaderos climáticamente inteligentes para la Norpatagonia info:eu-repograntAgreement/INTA/2023-PE-L01-I067, Mejoramiento genético y silvicultura de plantaciones para la producción sostenible de productos forestales para distintos destinos industriales info:eu-repograntAgreement/INTA/2019-RIST-E5-I111-001, Laboratorios de Diagnóstico Veterinario
dc.rights.none.fl_str_mv	info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv	restrictedAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv	application/pdf
dc.coverage.none.fl_str_mv	Argentina .......... (nation) (World, South America) 7006477
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	Toxicon 242 : 107712. (May 2024) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria
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repository.mail.fl_str_mv	tripaldi.nicolas@inta.gob.ar
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Pine needle abortions in cattle due to consumption of pinus ponderosa in Argentina: case reports

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