Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses

Autores
Hollmann, Axel; Cardoso, Nancy; Espeche, Juan C.; Maffía, Paulo C.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junín virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed. Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses.
Instituto de Virología
Fil: Hollmann, Axel. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; Argentina
Fil: Hollmann, Axel. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Hollmann, Axel. Universidad Nacional de Quilmes. Instituto de Microbiología Básica y Aplicada. Laboratorio de Microbiología Molecular; Argentina
Fil: Cardoso, Nancy. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Cardoso, Nancy. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Espeche, Juan C. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; Argentina
Fil: Espeche, Juan C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Maffía, Paulo C. Universidad Nacional de Hurlingham. Instituto de Biotecnología; Argentina
Fil: Maffía, Paulo C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fuente
Peptides 142 : 170570 (Agosto 2021)
Materia
Peptides
Antiviral Agents
Zoonoses
Animal Viruses
Péptidos
Viricidas
Zoonosis
Virus de los Animales
COVID-19
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/12019
Acceder
id INTADig_2bc7dc11163b9aa94c30cbaa6acf0ba0
oai_identifier_str oai:localhost:20.500.12123/12019
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Review of antiviral peptides for use against zoonotic and selected non-zoonotic virusesHollmann, AxelCardoso, NancyEspeche, Juan C.Maffía, Paulo C.PeptidesAntiviral AgentsZoonosesAnimal VirusesPéptidosViricidasZoonosisVirus de los AnimalesCOVID-19Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junín virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed. Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses.Instituto de VirologíaFil: Hollmann, Axel. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; ArgentinaFil: Hollmann, Axel. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Hollmann, Axel. Universidad Nacional de Quilmes. Instituto de Microbiología Básica y Aplicada. Laboratorio de Microbiología Molecular; ArgentinaFil: Cardoso, Nancy. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Cardoso, Nancy. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Espeche, Juan C. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; ArgentinaFil: Espeche, Juan C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Maffía, Paulo C. Universidad Nacional de Hurlingham. Instituto de Biotecnología; ArgentinaFil: Maffía, Paulo C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaElsevier2022-06-06T10:35:16Z2022-06-06T10:35:16Z2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/12019https://www.sciencedirect.com/science/article/pii/S01969781210007841873-5169https://doi.org/10.1016/j.peptides.2021.170570Peptides 142 : 170570 (Agosto 2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:45:34Zoai:localhost:20.500.12123/12019instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:35.203INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
title Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
spellingShingle Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
Hollmann, Axel
Peptides
Antiviral Agents
Zoonoses
Animal Viruses
Péptidos
Viricidas
Zoonosis
Virus de los Animales
COVID-19
title_short Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
title_full Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
title_fullStr Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
title_full_unstemmed Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
title_sort Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
dc.creator.none.fl_str_mv Hollmann, Axel
Cardoso, Nancy
Espeche, Juan C.
Maffía, Paulo C.
author Hollmann, Axel
author_facet Hollmann, Axel
Cardoso, Nancy
Espeche, Juan C.
Maffía, Paulo C.
author_role author
author2 Cardoso, Nancy
Espeche, Juan C.
Maffía, Paulo C.
author2_role author
author
author
dc.subject.none.fl_str_mv Peptides
Antiviral Agents
Zoonoses
Animal Viruses
Péptidos
Viricidas
Zoonosis
Virus de los Animales
COVID-19
topic Peptides
Antiviral Agents
Zoonoses
Animal Viruses
Péptidos
Viricidas
Zoonosis
Virus de los Animales
COVID-19
dc.description.none.fl_txt_mv Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junín virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed. Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses.
Instituto de Virología
Fil: Hollmann, Axel. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; Argentina
Fil: Hollmann, Axel. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Hollmann, Axel. Universidad Nacional de Quilmes. Instituto de Microbiología Básica y Aplicada. Laboratorio de Microbiología Molecular; Argentina
Fil: Cardoso, Nancy. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Cardoso, Nancy. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Espeche, Juan C. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; Argentina
Fil: Espeche, Juan C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Maffía, Paulo C. Universidad Nacional de Hurlingham. Instituto de Biotecnología; Argentina
Fil: Maffía, Paulo C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
description Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junín virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed. Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
2022-06-06T10:35:16Z
2022-06-06T10:35:16Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/12019
https://www.sciencedirect.com/science/article/pii/S0196978121000784
1873-5169
https://doi.org/10.1016/j.peptides.2021.170570
url http://hdl.handle.net/20.500.12123/12019
https://www.sciencedirect.com/science/article/pii/S0196978121000784
https://doi.org/10.1016/j.peptides.2021.170570
identifier_str_mv 1873-5169
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Peptides 142 : 170570 (Agosto 2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1844619165545005056
score 12.558318

Publicaciones similares