Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina

Autores
Cooper, Laura G.; Caffe, Gabriel; Cerutti, Julieta; Nielsen, Martin K.; Anziani, Oscar Sergio
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Macrocyclic lactones are the most widely used drugs for the control of gastrointestinal nematodes of horses in Argentina. Ivermectin and moxidectin are used as broad spectrum anthelmintics and although there are several international reports on the resistance of Parascaris spp., the resistance status of the local nematode population is largely unknow. This report informs a case of suboptimal efficacy to both drugs to control Parascaris spp. in foals in central Argentina. In February 2018, routine fecal parasite egg counts showed a moderate-high number of Parascaris spp. eggs (mean = 680 eggs per gram of feces) in foals treated approximately one month before with moxidectin. Upon suspicion of resistance of this parasite to the macrocyclic lactones, 24 of these animals were selected for a fecal egg count reduction test (FECRT). Twelve foals were treated with ivermectin and the remaining 12 animals with moxidectin. Two weeks after treatment, the FECRT was 48.1% and 34.8% for moxidectin and ivermectin respectively (25% of the animals increased the number of eggs in feces after treatment). Five days later, the administration of fenbendazole resulted in a FECRT = 100%. The monitoring of the status of susceptibility or resistance in each establishment is critical for the design of control programs based on rational and sustainable use of anthelmintics.
EEA Rafaela
Fil: Cooper, Laura G. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Caffe, Gabriel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Cerutti, Julieta. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Nielsen, Martin K. University of Kentucky. Gluck Equine Research Center; Estados Unidos
Fil: Anziani, Oscar Sergio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fuente
Veterinary Parasitology: Regional Studies and Reports : 100388 (Available online 20 February 2020)
Materia
Potro
Caballos
Parascaris
Plagas de Animales
Control de Plagas
Ivermectina
Argentina
Foals
Horses
Pests of Animals
Pest Control
Ivermectin
Moxidectina
Moxidectin
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/6819
Acceder
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oai_identifier_str oai:localhost:20.500.12123/6819
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from ArgentinaCooper, Laura G.Caffe, GabrielCerutti, JulietaNielsen, Martin K.Anziani, Oscar SergioPotroCaballosParascarisPlagas de AnimalesControl de PlagasIvermectinaArgentinaFoalsHorsesPests of AnimalsPest ControlIvermectinMoxidectinaMoxidectinMacrocyclic lactones are the most widely used drugs for the control of gastrointestinal nematodes of horses in Argentina. Ivermectin and moxidectin are used as broad spectrum anthelmintics and although there are several international reports on the resistance of Parascaris spp., the resistance status of the local nematode population is largely unknow. This report informs a case of suboptimal efficacy to both drugs to control Parascaris spp. in foals in central Argentina. In February 2018, routine fecal parasite egg counts showed a moderate-high number of Parascaris spp. eggs (mean = 680 eggs per gram of feces) in foals treated approximately one month before with moxidectin. Upon suspicion of resistance of this parasite to the macrocyclic lactones, 24 of these animals were selected for a fecal egg count reduction test (FECRT). Twelve foals were treated with ivermectin and the remaining 12 animals with moxidectin. Two weeks after treatment, the FECRT was 48.1% and 34.8% for moxidectin and ivermectin respectively (25% of the animals increased the number of eggs in feces after treatment). Five days later, the administration of fenbendazole resulted in a FECRT = 100%. The monitoring of the status of susceptibility or resistance in each establishment is critical for the design of control programs based on rational and sustainable use of anthelmintics.EEA RafaelaFil: Cooper, Laura G. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Caffe, Gabriel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Cerutti, Julieta. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Nielsen, Martin K. University of Kentucky. Gluck Equine Research Center; Estados UnidosFil: Anziani, Oscar Sergio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaElsevierinfo:eu-repo/date/embargoedEnd/2021-02-222020-02-21T12:37:18Z2020-02-21T12:37:18Z2020-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/6819https://www.sciencedirect.com/science/article/pii/S24059390193017652405-9390https://doi.org/10.1016/j.vprsr.2020.100388Veterinary Parasitology: Regional Studies and Reports : 100388 (Available online 20 February 2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-04T09:48:22Zoai:localhost:20.500.12123/6819instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:48:23.086INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina
title Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina
spellingShingle Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina
Cooper, Laura G.
Potro
Caballos
Parascaris
Plagas de Animales
Control de Plagas
Ivermectina
Argentina
Foals
Horses
Pests of Animals
Pest Control
Ivermectin
Moxidectina
Moxidectin
title_short Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina
title_full Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina
title_fullStr Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina
title_full_unstemmed Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina
title_sort Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina
dc.creator.none.fl_str_mv Cooper, Laura G.
Caffe, Gabriel
Cerutti, Julieta
Nielsen, Martin K.
Anziani, Oscar Sergio
author Cooper, Laura G.
author_facet Cooper, Laura G.
Caffe, Gabriel
Cerutti, Julieta
Nielsen, Martin K.
Anziani, Oscar Sergio
author_role author
author2 Caffe, Gabriel
Cerutti, Julieta
Nielsen, Martin K.
Anziani, Oscar Sergio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Potro
Caballos
Parascaris
Plagas de Animales
Control de Plagas
Ivermectina
Argentina
Foals
Horses
Pests of Animals
Pest Control
Ivermectin
Moxidectina
Moxidectin
topic Potro
Caballos
Parascaris
Plagas de Animales
Control de Plagas
Ivermectina
Argentina
Foals
Horses
Pests of Animals
Pest Control
Ivermectin
Moxidectina
Moxidectin
dc.description.none.fl_txt_mv Macrocyclic lactones are the most widely used drugs for the control of gastrointestinal nematodes of horses in Argentina. Ivermectin and moxidectin are used as broad spectrum anthelmintics and although there are several international reports on the resistance of Parascaris spp., the resistance status of the local nematode population is largely unknow. This report informs a case of suboptimal efficacy to both drugs to control Parascaris spp. in foals in central Argentina. In February 2018, routine fecal parasite egg counts showed a moderate-high number of Parascaris spp. eggs (mean = 680 eggs per gram of feces) in foals treated approximately one month before with moxidectin. Upon suspicion of resistance of this parasite to the macrocyclic lactones, 24 of these animals were selected for a fecal egg count reduction test (FECRT). Twelve foals were treated with ivermectin and the remaining 12 animals with moxidectin. Two weeks after treatment, the FECRT was 48.1% and 34.8% for moxidectin and ivermectin respectively (25% of the animals increased the number of eggs in feces after treatment). Five days later, the administration of fenbendazole resulted in a FECRT = 100%. The monitoring of the status of susceptibility or resistance in each establishment is critical for the design of control programs based on rational and sustainable use of anthelmintics.
EEA Rafaela
Fil: Cooper, Laura G. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Caffe, Gabriel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Cerutti, Julieta. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Nielsen, Martin K. University of Kentucky. Gluck Equine Research Center; Estados Unidos
Fil: Anziani, Oscar Sergio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
description Macrocyclic lactones are the most widely used drugs for the control of gastrointestinal nematodes of horses in Argentina. Ivermectin and moxidectin are used as broad spectrum anthelmintics and although there are several international reports on the resistance of Parascaris spp., the resistance status of the local nematode population is largely unknow. This report informs a case of suboptimal efficacy to both drugs to control Parascaris spp. in foals in central Argentina. In February 2018, routine fecal parasite egg counts showed a moderate-high number of Parascaris spp. eggs (mean = 680 eggs per gram of feces) in foals treated approximately one month before with moxidectin. Upon suspicion of resistance of this parasite to the macrocyclic lactones, 24 of these animals were selected for a fecal egg count reduction test (FECRT). Twelve foals were treated with ivermectin and the remaining 12 animals with moxidectin. Two weeks after treatment, the FECRT was 48.1% and 34.8% for moxidectin and ivermectin respectively (25% of the animals increased the number of eggs in feces after treatment). Five days later, the administration of fenbendazole resulted in a FECRT = 100%. The monitoring of the status of susceptibility or resistance in each establishment is critical for the design of control programs based on rational and sustainable use of anthelmintics.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-21T12:37:18Z
2020-02-21T12:37:18Z
2020-02
info:eu-repo/date/embargoedEnd/2021-02-22
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/6819
https://www.sciencedirect.com/science/article/pii/S2405939019301765
2405-9390
https://doi.org/10.1016/j.vprsr.2020.100388
url http://hdl.handle.net/20.500.12123/6819
https://www.sciencedirect.com/science/article/pii/S2405939019301765
https://doi.org/10.1016/j.vprsr.2020.100388
identifier_str_mv 2405-9390
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Veterinary Parasitology: Regional Studies and Reports : 100388 (Available online 20 February 2020)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.623145

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