Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)

Autores
Olaechea, Fermin; Lovera, V.; Larroza, Marcela Patricia; Raffo, Fernando; Cabrera, Raul Francisco
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Triclabendazol (TCBZ) es el fármaco más utilizado para el control de la fasciolosis en rumiantes. Es muy eficaz contra los estadios inmaduros y adultos de Fasciola spp. y frecuentes tratamientos dentro del período prepatente puede reducir la infección uke fl a un nivel insignificante.
In the winter of 2008, cattle on a farm in the province of Neuquen, Argentina died from subacute and chronic liver fluke disease despite four previous treatments with Triclabendazole (TCBZ). In the spring of 2009, a preliminary efficacy test revealed good performance using nitroxynil, whereas TCBZ efficacy was only 18% by egg counts of Fasciola eggs in the faeces. Resistance to Fasciola hepatica to TCBZ has never been reported in South America, so in January of 2010 a controlled trial was conducted to confirm and to define the degree of resistance in this herd. In a clinical trial, the fluke egg output was monitored on Days 14 and 21 and serum enzymes gamma-glutamyl transpeptidase (GGT) and glutamic-oxaloacetic transaminase (GOT) on Days 0 and 21 in 36 calves treated with TCBZ or with closantel. The results showed a reduction of 100% in fluke egg output at Days 14 and 21 for closantel. The mean epg in the TCBZ-treated groups did not decrease. Because of the fact that in this study TCBZ treatment in cattle had no effect, even at double the recommended dose, it is highly indicative that resistance of F. hepatica against TCBZ is present on this farm. The GGT and GOT levels decreased in the closantel-treated group as a result of the treatment at 21 days after dosing. To evaluate the importance of TCBZ resistance in F. hepatica in Argentina, a study on more farms from endemic areas is needed.
EEA Bariloche
Fil: Olaechea, Fermin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina
Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina
Fil: Raffo, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina
Fil: Cabrera, Raul Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina
Fuente
Veterinary parasitology 178 (3–4) : 364-366. (June 2011)
Materia
Enfermedades de los Animales
Fasciola Hepatica
Resistencia a la Enfermedad
Ganado Bovino
Animal Diseases
Disease Resistance
Cattle
Región Patagónica
Triclabendazole
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/1603
Acceder
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oai_identifier_str oai:localhost:20.500.12123/1603
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)Olaechea, FerminLovera, V.Larroza, Marcela PatriciaRaffo, FernandoCabrera, Raul FranciscoEnfermedades de los AnimalesFasciola HepaticaResistencia a la EnfermedadGanado BovinoAnimal DiseasesDisease ResistanceCattleRegión PatagónicaTriclabendazoleTriclabendazol (TCBZ) es el fármaco más utilizado para el control de la fasciolosis en rumiantes. Es muy eficaz contra los estadios inmaduros y adultos de Fasciola spp. y frecuentes tratamientos dentro del período prepatente puede reducir la infección uke fl a un nivel insignificante.In the winter of 2008, cattle on a farm in the province of Neuquen, Argentina died from subacute and chronic liver fluke disease despite four previous treatments with Triclabendazole (TCBZ). In the spring of 2009, a preliminary efficacy test revealed good performance using nitroxynil, whereas TCBZ efficacy was only 18% by egg counts of Fasciola eggs in the faeces. Resistance to Fasciola hepatica to TCBZ has never been reported in South America, so in January of 2010 a controlled trial was conducted to confirm and to define the degree of resistance in this herd. In a clinical trial, the fluke egg output was monitored on Days 14 and 21 and serum enzymes gamma-glutamyl transpeptidase (GGT) and glutamic-oxaloacetic transaminase (GOT) on Days 0 and 21 in 36 calves treated with TCBZ or with closantel. The results showed a reduction of 100% in fluke egg output at Days 14 and 21 for closantel. The mean epg in the TCBZ-treated groups did not decrease. Because of the fact that in this study TCBZ treatment in cattle had no effect, even at double the recommended dose, it is highly indicative that resistance of F. hepatica against TCBZ is present on this farm. The GGT and GOT levels decreased in the closantel-treated group as a result of the treatment at 21 days after dosing. To evaluate the importance of TCBZ resistance in F. hepatica in Argentina, a study on more farms from endemic areas is needed.EEA BarilocheFil: Olaechea, Fermin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; ArgentinaFil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; ArgentinaFil: Raffo, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; ArgentinaFil: Cabrera, Raul Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina2017-10-27T11:32:52Z2017-10-27T11:32:52Z2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/1603https://www.sciencedirect.com/science/article/pii/S0304401711000161?via%3Dihub0304-4017https://doi.org/10.1016/j.vetpar.2010.12.047Veterinary parasitology 178 (3–4) : 364-366. (June 2011)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-04T09:47:06Zoai:localhost:20.500.12123/1603instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:47:07.362INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
title Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
spellingShingle Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
Olaechea, Fermin
Enfermedades de los Animales
Fasciola Hepatica
Resistencia a la Enfermedad
Ganado Bovino
Animal Diseases
Disease Resistance
Cattle
Región Patagónica
Triclabendazole
title_short Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
title_full Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
title_fullStr Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
title_full_unstemmed Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
title_sort Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
dc.creator.none.fl_str_mv Olaechea, Fermin
Lovera, V.
Larroza, Marcela Patricia
Raffo, Fernando
Cabrera, Raul Francisco
author Olaechea, Fermin
author_facet Olaechea, Fermin
Lovera, V.
Larroza, Marcela Patricia
Raffo, Fernando
Cabrera, Raul Francisco
author_role author
author2 Lovera, V.
Larroza, Marcela Patricia
Raffo, Fernando
Cabrera, Raul Francisco
author2_role author
author
author
author
dc.subject.none.fl_str_mv Enfermedades de los Animales
Fasciola Hepatica
Resistencia a la Enfermedad
Ganado Bovino
Animal Diseases
Disease Resistance
Cattle
Región Patagónica
Triclabendazole
topic Enfermedades de los Animales
Fasciola Hepatica
Resistencia a la Enfermedad
Ganado Bovino
Animal Diseases
Disease Resistance
Cattle
Región Patagónica
Triclabendazole
dc.description.none.fl_txt_mv Triclabendazol (TCBZ) es el fármaco más utilizado para el control de la fasciolosis en rumiantes. Es muy eficaz contra los estadios inmaduros y adultos de Fasciola spp. y frecuentes tratamientos dentro del período prepatente puede reducir la infección uke fl a un nivel insignificante.
In the winter of 2008, cattle on a farm in the province of Neuquen, Argentina died from subacute and chronic liver fluke disease despite four previous treatments with Triclabendazole (TCBZ). In the spring of 2009, a preliminary efficacy test revealed good performance using nitroxynil, whereas TCBZ efficacy was only 18% by egg counts of Fasciola eggs in the faeces. Resistance to Fasciola hepatica to TCBZ has never been reported in South America, so in January of 2010 a controlled trial was conducted to confirm and to define the degree of resistance in this herd. In a clinical trial, the fluke egg output was monitored on Days 14 and 21 and serum enzymes gamma-glutamyl transpeptidase (GGT) and glutamic-oxaloacetic transaminase (GOT) on Days 0 and 21 in 36 calves treated with TCBZ or with closantel. The results showed a reduction of 100% in fluke egg output at Days 14 and 21 for closantel. The mean epg in the TCBZ-treated groups did not decrease. Because of the fact that in this study TCBZ treatment in cattle had no effect, even at double the recommended dose, it is highly indicative that resistance of F. hepatica against TCBZ is present on this farm. The GGT and GOT levels decreased in the closantel-treated group as a result of the treatment at 21 days after dosing. To evaluate the importance of TCBZ resistance in F. hepatica in Argentina, a study on more farms from endemic areas is needed.
EEA Bariloche
Fil: Olaechea, Fermin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina
Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina
Fil: Raffo, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina
Fil: Cabrera, Raul Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina
description Triclabendazol (TCBZ) es el fármaco más utilizado para el control de la fasciolosis en rumiantes. Es muy eficaz contra los estadios inmaduros y adultos de Fasciola spp. y frecuentes tratamientos dentro del período prepatente puede reducir la infección uke fl a un nivel insignificante.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
2017-10-27T11:32:52Z
2017-10-27T11:32:52Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/1603
https://www.sciencedirect.com/science/article/pii/S0304401711000161?via%3Dihub
0304-4017
https://doi.org/10.1016/j.vetpar.2010.12.047
url http://hdl.handle.net/20.500.12123/1603
https://www.sciencedirect.com/science/article/pii/S0304401711000161?via%3Dihub
https://doi.org/10.1016/j.vetpar.2010.12.047
identifier_str_mv 0304-4017
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Veterinary parasitology 178 (3–4) : 364-366. (June 2011)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.623145

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