Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes
- Autores
- Vazquez Prieto, Marcela Alejandra; Bettaieb, Ahmed; Rodriguez Lanzi, Cecilia; Soto Vargas, Verónica Carolina; Perdicaro, Diahann Jeanette; Galmarini, Claudio Romulo; Haj, Fawaz G.; Miatello, Roberto Miguel; Oteiza, Patricia I.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Scope This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF‐α) in 3T3‐L1 adipocytes. Methods and results In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3‐L1 adipocytes, C and Q attenuated TNF‐α‐induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP‐1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen‐activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR‐γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF‐α, MCP‐1, resistin) insulin sensitivity. Conclusion Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS‐associated adipose inflammation, oxidative stress, and insulin resistance.
EEA La Consulta
Fil: Vazquez Prieto, Marcela Alejandra. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Bettaieb, Ahmed. University of California. Department of Nutrition; Estados Unidos
Fil: Rodriguez Lanzi, Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Soto Vargas, Verónica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Perdicaro, Diahann Jeanette. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Galmarini, Claudio Romulo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentina
Fil: Haj, Fawaz G. University of California. Department of Nutrition; Estados Unidos. University of California. Department of Internal Medicine; Estados Unidos
Fil: Miatello, Roberto Miguel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Oteiza, Patricia I. University of California. Department of Nutrition; Estados Unidos. University of California. Department of Environmental Toxicology; Estados Unidos - Fuente
- Molecular nutrition and food research 59 (4) : 622-633. (April 2015)
- Materia
-
Catechin
Quercetin
Adipose Tissue
Inflammation
Flavonoids
Fructose
Catequina
Quercetina
Tejido Adiposo
Inflamación
Flavonoides
Fructosa
Metabolic Syndrome
Síndrome Metabólico - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- Repositorio
.jpg)
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/4509
Ver los metadatos del registro completo
| id |
INTADig_1849908ab8452b484e6ed02414f6c540 |
|---|---|
| oai_identifier_str |
oai:localhost:20.500.12123/4509 |
| network_acronym_str |
INTADig |
| repository_id_str |
l |
| network_name_str |
INTA Digital (INTA) |
| spelling |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytesVazquez Prieto, Marcela AlejandraBettaieb, AhmedRodriguez Lanzi, CeciliaSoto Vargas, Verónica CarolinaPerdicaro, Diahann JeanetteGalmarini, Claudio RomuloHaj, Fawaz G.Miatello, Roberto MiguelOteiza, Patricia I.CatechinQuercetinAdipose TissueInflammationFlavonoidsFructoseCatequinaQuercetinaTejido AdiposoInflamaciónFlavonoidesFructosaMetabolic SyndromeSíndrome MetabólicoScope This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF‐α) in 3T3‐L1 adipocytes. Methods and results In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3‐L1 adipocytes, C and Q attenuated TNF‐α‐induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP‐1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen‐activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR‐γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF‐α, MCP‐1, resistin) insulin sensitivity. Conclusion Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS‐associated adipose inflammation, oxidative stress, and insulin resistance.EEA La ConsultaFil: Vazquez Prieto, Marcela Alejandra. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Bettaieb, Ahmed. University of California. Department of Nutrition; Estados UnidosFil: Rodriguez Lanzi, Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Soto Vargas, Verónica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Perdicaro, Diahann Jeanette. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Galmarini, Claudio Romulo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; ArgentinaFil: Haj, Fawaz G. University of California. Department of Nutrition; Estados Unidos. University of California. Department of Internal Medicine; Estados UnidosFil: Miatello, Roberto Miguel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Oteiza, Patricia I. University of California. Department of Nutrition; Estados Unidos. University of California. Department of Environmental Toxicology; Estados UnidosWiley2019-02-27T17:20:41Z2019-02-27T17:20:41Z2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/45091613-41251613-4133 (Online)https://doi.org/10.1002/mnfr.201400631Molecular nutrition and food research 59 (4) : 622-633. (April 2015)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-04T09:47:50Zoai:localhost:20.500.12123/4509instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:47:51.088INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
| dc.title.none.fl_str_mv |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| spellingShingle |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes Vazquez Prieto, Marcela Alejandra Catechin Quercetin Adipose Tissue Inflammation Flavonoids Fructose Catequina Quercetina Tejido Adiposo Inflamación Flavonoides Fructosa Metabolic Syndrome Síndrome Metabólico |
| title_short |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_full |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_fullStr |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_full_unstemmed |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_sort |
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| dc.creator.none.fl_str_mv |
Vazquez Prieto, Marcela Alejandra Bettaieb, Ahmed Rodriguez Lanzi, Cecilia Soto Vargas, Verónica Carolina Perdicaro, Diahann Jeanette Galmarini, Claudio Romulo Haj, Fawaz G. Miatello, Roberto Miguel Oteiza, Patricia I. |
| author |
Vazquez Prieto, Marcela Alejandra |
| author_facet |
Vazquez Prieto, Marcela Alejandra Bettaieb, Ahmed Rodriguez Lanzi, Cecilia Soto Vargas, Verónica Carolina Perdicaro, Diahann Jeanette Galmarini, Claudio Romulo Haj, Fawaz G. Miatello, Roberto Miguel Oteiza, Patricia I. |
| author_role |
author |
| author2 |
Bettaieb, Ahmed Rodriguez Lanzi, Cecilia Soto Vargas, Verónica Carolina Perdicaro, Diahann Jeanette Galmarini, Claudio Romulo Haj, Fawaz G. Miatello, Roberto Miguel Oteiza, Patricia I. |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Catechin Quercetin Adipose Tissue Inflammation Flavonoids Fructose Catequina Quercetina Tejido Adiposo Inflamación Flavonoides Fructosa Metabolic Syndrome Síndrome Metabólico |
| topic |
Catechin Quercetin Adipose Tissue Inflammation Flavonoids Fructose Catequina Quercetina Tejido Adiposo Inflamación Flavonoides Fructosa Metabolic Syndrome Síndrome Metabólico |
| dc.description.none.fl_txt_mv |
Scope This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF‐α) in 3T3‐L1 adipocytes. Methods and results In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3‐L1 adipocytes, C and Q attenuated TNF‐α‐induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP‐1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen‐activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR‐γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF‐α, MCP‐1, resistin) insulin sensitivity. Conclusion Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS‐associated adipose inflammation, oxidative stress, and insulin resistance. EEA La Consulta Fil: Vazquez Prieto, Marcela Alejandra. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Bettaieb, Ahmed. University of California. Department of Nutrition; Estados Unidos Fil: Rodriguez Lanzi, Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Soto Vargas, Verónica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina Fil: Perdicaro, Diahann Jeanette. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Galmarini, Claudio Romulo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentina Fil: Haj, Fawaz G. University of California. Department of Nutrition; Estados Unidos. University of California. Department of Internal Medicine; Estados Unidos Fil: Miatello, Roberto Miguel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Oteiza, Patricia I. University of California. Department of Nutrition; Estados Unidos. University of California. Department of Environmental Toxicology; Estados Unidos |
| description |
Scope This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF‐α) in 3T3‐L1 adipocytes. Methods and results In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3‐L1 adipocytes, C and Q attenuated TNF‐α‐induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP‐1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen‐activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR‐γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF‐α, MCP‐1, resistin) insulin sensitivity. Conclusion Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS‐associated adipose inflammation, oxidative stress, and insulin resistance. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-04 2019-02-27T17:20:41Z 2019-02-27T17:20:41Z |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/4509 1613-4125 1613-4133 (Online) https://doi.org/10.1002/mnfr.201400631 |
| url |
http://hdl.handle.net/20.500.12123/4509 https://doi.org/10.1002/mnfr.201400631 |
| identifier_str_mv |
1613-4125 1613-4133 (Online) |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess |
| eu_rights_str_mv |
restrictedAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
Molecular nutrition and food research 59 (4) : 622-633. (April 2015) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
| reponame_str |
INTA Digital (INTA) |
| collection |
INTA Digital (INTA) |
| instname_str |
Instituto Nacional de Tecnología Agropecuaria |
| repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
| repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
| _version_ |
1842341363588268032 |
| score |
12.623145 |