Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes

Autores
Vazquez, Marcela Alejandra; Bettaieb, Ahmed; Rodriguez Lanzi, Maria Cecilia; Soto Vargas, Verónica Carolina; Perdicaro, Diahann Jeanette; Galmarini, Claudio Romulo; Haj, Fawaz G.; Miatello, Roberto Miguel; Oteiza, Patricia Isabel
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Scope: This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF-α) in 3T3-L1 adipocytes. Methods and results: In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3-L1 adipocytes, C and Q attenuated TNF-α-induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP-1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen-activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR-γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF-α, MCP-1, resistin) insulin sensitivity. Conclusion: Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS-associated adipose inflammation, oxidative stress, and insulin resistance.
Fil: Vazquez, Marcela Alejandra. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Bettaieb, Ahmed. University of California; Estados Unidos
Fil: Rodriguez Lanzi, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Soto Vargas, Verónica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Perdicaro, Diahann Jeanette. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Galmarini, Claudio Romulo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Haj, Fawaz G.. University of California; Estados Unidos
Fil: Miatello, Roberto Miguel. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Oteiza, Patricia Isabel. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ADIPOKINES
ADIPOSE TISSUE INFLAMMATION
FLAVONOIDS
HIGH FRUCTOSE DIET
METABOLIC SYNDROME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/124641
Acceder
id CONICETDig_6bfa1918bafd0f055fa26a7a3dc492eb
oai_identifier_str oai:ri.conicet.gov.ar:11336/124641
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytesVazquez, Marcela AlejandraBettaieb, AhmedRodriguez Lanzi, Maria CeciliaSoto Vargas, Verónica CarolinaPerdicaro, Diahann JeanetteGalmarini, Claudio RomuloHaj, Fawaz G.Miatello, Roberto MiguelOteiza, Patricia IsabelADIPOKINESADIPOSE TISSUE INFLAMMATIONFLAVONOIDSHIGH FRUCTOSE DIETMETABOLIC SYNDROMEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Scope: This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF-α) in 3T3-L1 adipocytes. Methods and results: In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3-L1 adipocytes, C and Q attenuated TNF-α-induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP-1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen-activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR-γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF-α, MCP-1, resistin) insulin sensitivity. Conclusion: Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS-associated adipose inflammation, oxidative stress, and insulin resistance.Fil: Vazquez, Marcela Alejandra. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Bettaieb, Ahmed. University of California; Estados UnidosFil: Rodriguez Lanzi, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; ArgentinaFil: Soto Vargas, Verónica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Perdicaro, Diahann Jeanette. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; ArgentinaFil: Galmarini, Claudio Romulo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Haj, Fawaz G.. University of California; Estados UnidosFil: Miatello, Roberto Miguel. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Oteiza, Patricia Isabel. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley VCH Verlag2015-01-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124641Vazquez, Marcela Alejandra; Bettaieb, Ahmed; Rodriguez Lanzi, Maria Cecilia; Soto Vargas, Verónica Carolina; Perdicaro, Diahann Jeanette; et al.; Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes; Wiley VCH Verlag; Molecular Nutrition & Food Research; 59; 4; 24-1-2015; 622-6331613-4125CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201400631info:eu-repo/semantics/altIdentifier/doi/10.1002/mnfr.201400631info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:20Zoai:ri.conicet.gov.ar:11336/124641instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:20.358CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
title Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
spellingShingle Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
Vazquez, Marcela Alejandra
ADIPOKINES
ADIPOSE TISSUE INFLAMMATION
FLAVONOIDS
HIGH FRUCTOSE DIET
METABOLIC SYNDROME
title_short Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
title_full Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
title_fullStr Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
title_full_unstemmed Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
title_sort Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
dc.creator.none.fl_str_mv Vazquez, Marcela Alejandra
Bettaieb, Ahmed
Rodriguez Lanzi, Maria Cecilia
Soto Vargas, Verónica Carolina
Perdicaro, Diahann Jeanette
Galmarini, Claudio Romulo
Haj, Fawaz G.
Miatello, Roberto Miguel
Oteiza, Patricia Isabel
author Vazquez, Marcela Alejandra
author_facet Vazquez, Marcela Alejandra
Bettaieb, Ahmed
Rodriguez Lanzi, Maria Cecilia
Soto Vargas, Verónica Carolina
Perdicaro, Diahann Jeanette
Galmarini, Claudio Romulo
Haj, Fawaz G.
Miatello, Roberto Miguel
Oteiza, Patricia Isabel
author_role author
author2 Bettaieb, Ahmed
Rodriguez Lanzi, Maria Cecilia
Soto Vargas, Verónica Carolina
Perdicaro, Diahann Jeanette
Galmarini, Claudio Romulo
Haj, Fawaz G.
Miatello, Roberto Miguel
Oteiza, Patricia Isabel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADIPOKINES
ADIPOSE TISSUE INFLAMMATION
FLAVONOIDS
HIGH FRUCTOSE DIET
METABOLIC SYNDROME
topic ADIPOKINES
ADIPOSE TISSUE INFLAMMATION
FLAVONOIDS
HIGH FRUCTOSE DIET
METABOLIC SYNDROME
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Scope: This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF-α) in 3T3-L1 adipocytes. Methods and results: In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3-L1 adipocytes, C and Q attenuated TNF-α-induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP-1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen-activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR-γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF-α, MCP-1, resistin) insulin sensitivity. Conclusion: Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS-associated adipose inflammation, oxidative stress, and insulin resistance.
Fil: Vazquez, Marcela Alejandra. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Bettaieb, Ahmed. University of California; Estados Unidos
Fil: Rodriguez Lanzi, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Soto Vargas, Verónica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Perdicaro, Diahann Jeanette. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Galmarini, Claudio Romulo. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Haj, Fawaz G.. University of California; Estados Unidos
Fil: Miatello, Roberto Miguel. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Oteiza, Patricia Isabel. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Scope: This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF-α) in 3T3-L1 adipocytes. Methods and results: In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3-L1 adipocytes, C and Q attenuated TNF-α-induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP-1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen-activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR-γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF-α, MCP-1, resistin) insulin sensitivity. Conclusion: Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS-associated adipose inflammation, oxidative stress, and insulin resistance.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124641
Vazquez, Marcela Alejandra; Bettaieb, Ahmed; Rodriguez Lanzi, Maria Cecilia; Soto Vargas, Verónica Carolina; Perdicaro, Diahann Jeanette; et al.; Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes; Wiley VCH Verlag; Molecular Nutrition & Food Research; 59; 4; 24-1-2015; 622-633
1613-4125
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124641
identifier_str_mv Vazquez, Marcela Alejandra; Bettaieb, Ahmed; Rodriguez Lanzi, Maria Cecilia; Soto Vargas, Verónica Carolina; Perdicaro, Diahann Jeanette; et al.; Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes; Wiley VCH Verlag; Molecular Nutrition & Food Research; 59; 4; 24-1-2015; 622-633
1613-4125
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201400631
info:eu-repo/semantics/altIdentifier/doi/10.1002/mnfr.201400631
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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