Hippocampal interleukin-1β gene expression during long-term potentiation decays with age

Autores
Balschun, Detlef; Randolf, Anke; Pitossi, Fernando Juan; Schneider, Horst; Del Rey, Adriana; Besedovsky, Hugo O.
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Interleukin-1 is a cytokine that, apart from its contribution to immunoregulation, can affect neuroendocrine mechanisms and brain functions. We have previously shown that an increase in the endogenous production of IL-1 in the dentate gyrus during LTP is relevant for the maintenance of this process. We report here that in middle-aged rats (12 to 16 months old), enhancement of IL-1 gene expression is diminished compared to that in young animals. Furthermore, basal levels of IL-1 gene expression were slightly reduced in middle-aged rats. The reduced upregulation of IL-1 gene expression during LTP was not accompanied by overt impairment of potentiation, suggesting that either the level of the cytokine is still enough to maintain synaptic plasticity in the dentate gyrus or that compensatory, probably less efficient, mechanisms develop during aging.
Fil: Balschun, Detlef. Leibniz Institute For Neurobiology; Alemania
Fil: Randolf, Anke. Philipps Universität Marburg; Alemania
Fil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Schneider, Horst. Philipps Universität Marburg; Alemania
Fil: Del Rey, Adriana. Philipps Universität Marburg; Alemania
Fil: Besedovsky, Hugo O.. Philipps Universität Marburg; Alemania
Materia
CYTOKINES
GENE EXPRESSION
HIPPOCAMPUS
INTERLEUKIN-1 (II-1)
LONG-TERM POTENTIATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/101544
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hippocampal interleukin-1β gene expression during long-term potentiation decays with ageBalschun, DetlefRandolf, AnkePitossi, Fernando JuanSchneider, HorstDel Rey, AdrianaBesedovsky, Hugo O.CYTOKINESGENE EXPRESSIONHIPPOCAMPUSINTERLEUKIN-1 (II-1)LONG-TERM POTENTIATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Interleukin-1 is a cytokine that, apart from its contribution to immunoregulation, can affect neuroendocrine mechanisms and brain functions. We have previously shown that an increase in the endogenous production of IL-1 in the dentate gyrus during LTP is relevant for the maintenance of this process. We report here that in middle-aged rats (12 to 16 months old), enhancement of IL-1 gene expression is diminished compared to that in young animals. Furthermore, basal levels of IL-1 gene expression were slightly reduced in middle-aged rats. The reduced upregulation of IL-1 gene expression during LTP was not accompanied by overt impairment of potentiation, suggesting that either the level of the cytokine is still enough to maintain synaptic plasticity in the dentate gyrus or that compensatory, probably less efficient, mechanisms develop during aging.Fil: Balschun, Detlef. Leibniz Institute For Neurobiology; AlemaniaFil: Randolf, Anke. Philipps Universität Marburg; AlemaniaFil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Schneider, Horst. Philipps Universität Marburg; AlemaniaFil: Del Rey, Adriana. Philipps Universität Marburg; AlemaniaFil: Besedovsky, Hugo O.. Philipps Universität Marburg; AlemaniaBlackwell Publishing2003-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/101544Balschun, Detlef; Randolf, Anke; Pitossi, Fernando Juan; Schneider, Horst; Del Rey, Adriana; et al.; Hippocampal interleukin-1β gene expression during long-term potentiation decays with age; Blackwell Publishing; Annals of the New York Academy of Sciences; 992; 1; 5-2003; 1-80077-89231749-6632CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2003.tb03132.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2003.tb03132.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:51:01Zoai:ri.conicet.gov.ar:11336/101544instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:51:01.699CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
title Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
spellingShingle Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
Balschun, Detlef
CYTOKINES
GENE EXPRESSION
HIPPOCAMPUS
INTERLEUKIN-1 (II-1)
LONG-TERM POTENTIATION
title_short Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
title_full Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
title_fullStr Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
title_full_unstemmed Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
title_sort Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
dc.creator.none.fl_str_mv Balschun, Detlef
Randolf, Anke
Pitossi, Fernando Juan
Schneider, Horst
Del Rey, Adriana
Besedovsky, Hugo O.
author Balschun, Detlef
author_facet Balschun, Detlef
Randolf, Anke
Pitossi, Fernando Juan
Schneider, Horst
Del Rey, Adriana
Besedovsky, Hugo O.
author_role author
author2 Randolf, Anke
Pitossi, Fernando Juan
Schneider, Horst
Del Rey, Adriana
Besedovsky, Hugo O.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CYTOKINES
GENE EXPRESSION
HIPPOCAMPUS
INTERLEUKIN-1 (II-1)
LONG-TERM POTENTIATION
topic CYTOKINES
GENE EXPRESSION
HIPPOCAMPUS
INTERLEUKIN-1 (II-1)
LONG-TERM POTENTIATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Interleukin-1 is a cytokine that, apart from its contribution to immunoregulation, can affect neuroendocrine mechanisms and brain functions. We have previously shown that an increase in the endogenous production of IL-1 in the dentate gyrus during LTP is relevant for the maintenance of this process. We report here that in middle-aged rats (12 to 16 months old), enhancement of IL-1 gene expression is diminished compared to that in young animals. Furthermore, basal levels of IL-1 gene expression were slightly reduced in middle-aged rats. The reduced upregulation of IL-1 gene expression during LTP was not accompanied by overt impairment of potentiation, suggesting that either the level of the cytokine is still enough to maintain synaptic plasticity in the dentate gyrus or that compensatory, probably less efficient, mechanisms develop during aging.
Fil: Balschun, Detlef. Leibniz Institute For Neurobiology; Alemania
Fil: Randolf, Anke. Philipps Universität Marburg; Alemania
Fil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Schneider, Horst. Philipps Universität Marburg; Alemania
Fil: Del Rey, Adriana. Philipps Universität Marburg; Alemania
Fil: Besedovsky, Hugo O.. Philipps Universität Marburg; Alemania
description Interleukin-1 is a cytokine that, apart from its contribution to immunoregulation, can affect neuroendocrine mechanisms and brain functions. We have previously shown that an increase in the endogenous production of IL-1 in the dentate gyrus during LTP is relevant for the maintenance of this process. We report here that in middle-aged rats (12 to 16 months old), enhancement of IL-1 gene expression is diminished compared to that in young animals. Furthermore, basal levels of IL-1 gene expression were slightly reduced in middle-aged rats. The reduced upregulation of IL-1 gene expression during LTP was not accompanied by overt impairment of potentiation, suggesting that either the level of the cytokine is still enough to maintain synaptic plasticity in the dentate gyrus or that compensatory, probably less efficient, mechanisms develop during aging.
publishDate 2003
dc.date.none.fl_str_mv 2003-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/101544
Balschun, Detlef; Randolf, Anke; Pitossi, Fernando Juan; Schneider, Horst; Del Rey, Adriana; et al.; Hippocampal interleukin-1β gene expression during long-term potentiation decays with age; Blackwell Publishing; Annals of the New York Academy of Sciences; 992; 1; 5-2003; 1-8
0077-8923
1749-6632
CONICET Digital
CONICET
url http://hdl.handle.net/11336/101544
identifier_str_mv Balschun, Detlef; Randolf, Anke; Pitossi, Fernando Juan; Schneider, Horst; Del Rey, Adriana; et al.; Hippocampal interleukin-1β gene expression during long-term potentiation decays with age; Blackwell Publishing; Annals of the New York Academy of Sciences; 992; 1; 5-2003; 1-8
0077-8923
1749-6632
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2003.tb03132.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2003.tb03132.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1849872834414772224
score 13.011256

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