Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study

Autores
van de Broeke, Emanuel N.; Vanmaele, Tessa; Mouraux, André; Stouffs, Alexandre; Biurrun Manresa, José Alberto; Torta, Diana M.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibres induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers, we applied HFS to the left or right volar forearm. Before and after applying HFS, we delivered single electrical test stimuli through the HFS electrode while a second electrode at the contra-lateral arm served as a control condition. Moreover, to test the efficacy of the HFS protocol, we quantified changes in mechanical pinprick sensitivity before and after HFS of the skin surrounding both electrodes. The perceived intensity was collected for both electrical and mechanical stimuli. After HFS, the perceived pain intensity elicited by the mechanical pinprick stimuli applied on the skin surrounding the HFS-treated site was significantly higher compared to control site (heterotopic effect). Furthermore, we found a higher perceived pain intensity for single electrical stimuli delivered to the HFS-treated site compared to the control site (homotopic effect). Whether the homotopic effect reflects a perceptual correlate of homosynaptic LTP remains to be elucidated.
Fil: van de Broeke, Emanuel N.. Université Catholique de Louvain; Bélgica
Fil: Vanmaele, Tessa. Katholikie Universiteit Leuven; Bélgica
Fil: Mouraux, André. Université Catholique de Louvain; Bélgica
Fil: Stouffs, Alexandre. Université Catholique de Louvain; Bélgica
Fil: Biurrun Manresa, José Alberto. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina
Fil: Torta, Diana M.. Katholikie Universiteit Leuven; Bélgica
Materia
HIGH-FREQUENCY STIMULATION
HOMOTOPIC HYPERALGESIA
LONG-TERM POTENTIATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173438
Acceder
id CONICETDig_a9933c5431e5ae4c264cc9b46130d066
oai_identifier_str oai:ri.conicet.gov.ar:11336/173438
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication studyvan de Broeke, Emanuel N.Vanmaele, TessaMouraux, AndréStouffs, AlexandreBiurrun Manresa, José AlbertoTorta, Diana M.HIGH-FREQUENCY STIMULATIONHOMOTOPIC HYPERALGESIALONG-TERM POTENTIATIONhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibres induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers, we applied HFS to the left or right volar forearm. Before and after applying HFS, we delivered single electrical test stimuli through the HFS electrode while a second electrode at the contra-lateral arm served as a control condition. Moreover, to test the efficacy of the HFS protocol, we quantified changes in mechanical pinprick sensitivity before and after HFS of the skin surrounding both electrodes. The perceived intensity was collected for both electrical and mechanical stimuli. After HFS, the perceived pain intensity elicited by the mechanical pinprick stimuli applied on the skin surrounding the HFS-treated site was significantly higher compared to control site (heterotopic effect). Furthermore, we found a higher perceived pain intensity for single electrical stimuli delivered to the HFS-treated site compared to the control site (homotopic effect). Whether the homotopic effect reflects a perceptual correlate of homosynaptic LTP remains to be elucidated.Fil: van de Broeke, Emanuel N.. Université Catholique de Louvain; BélgicaFil: Vanmaele, Tessa. Katholikie Universiteit Leuven; BélgicaFil: Mouraux, André. Université Catholique de Louvain; BélgicaFil: Stouffs, Alexandre. Université Catholique de Louvain; BélgicaFil: Biurrun Manresa, José Alberto. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; ArgentinaFil: Torta, Diana M.. Katholikie Universiteit Leuven; BélgicaThe Royal Society2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173438van de Broeke, Emanuel N.; Vanmaele, Tessa; Mouraux, André; Stouffs, Alexandre; Biurrun Manresa, José Alberto; et al.; Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study; The Royal Society; Royal Society Open Science; 8; 1; 1-2021; 1-132054-5703CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1098/rsos.200830info:eu-repo/semantics/altIdentifier/doi/10.1098/rsos.200830info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:11:48Zoai:ri.conicet.gov.ar:11336/173438instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:11:48.321CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study
title Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study
spellingShingle Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study
van de Broeke, Emanuel N.
HIGH-FREQUENCY STIMULATION
HOMOTOPIC HYPERALGESIA
LONG-TERM POTENTIATION
title_short Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study
title_full Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study
title_fullStr Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study
title_full_unstemmed Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study
title_sort Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study
dc.creator.none.fl_str_mv van de Broeke, Emanuel N.
Vanmaele, Tessa
Mouraux, André
Stouffs, Alexandre
Biurrun Manresa, José Alberto
Torta, Diana M.
author van de Broeke, Emanuel N.
author_facet van de Broeke, Emanuel N.
Vanmaele, Tessa
Mouraux, André
Stouffs, Alexandre
Biurrun Manresa, José Alberto
Torta, Diana M.
author_role author
author2 Vanmaele, Tessa
Mouraux, André
Stouffs, Alexandre
Biurrun Manresa, José Alberto
Torta, Diana M.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HIGH-FREQUENCY STIMULATION
HOMOTOPIC HYPERALGESIA
LONG-TERM POTENTIATION
topic HIGH-FREQUENCY STIMULATION
HOMOTOPIC HYPERALGESIA
LONG-TERM POTENTIATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibres induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers, we applied HFS to the left or right volar forearm. Before and after applying HFS, we delivered single electrical test stimuli through the HFS electrode while a second electrode at the contra-lateral arm served as a control condition. Moreover, to test the efficacy of the HFS protocol, we quantified changes in mechanical pinprick sensitivity before and after HFS of the skin surrounding both electrodes. The perceived intensity was collected for both electrical and mechanical stimuli. After HFS, the perceived pain intensity elicited by the mechanical pinprick stimuli applied on the skin surrounding the HFS-treated site was significantly higher compared to control site (heterotopic effect). Furthermore, we found a higher perceived pain intensity for single electrical stimuli delivered to the HFS-treated site compared to the control site (homotopic effect). Whether the homotopic effect reflects a perceptual correlate of homosynaptic LTP remains to be elucidated.
Fil: van de Broeke, Emanuel N.. Université Catholique de Louvain; Bélgica
Fil: Vanmaele, Tessa. Katholikie Universiteit Leuven; Bélgica
Fil: Mouraux, André. Université Catholique de Louvain; Bélgica
Fil: Stouffs, Alexandre. Université Catholique de Louvain; Bélgica
Fil: Biurrun Manresa, José Alberto. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina
Fil: Torta, Diana M.. Katholikie Universiteit Leuven; Bélgica
description Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibres induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers, we applied HFS to the left or right volar forearm. Before and after applying HFS, we delivered single electrical test stimuli through the HFS electrode while a second electrode at the contra-lateral arm served as a control condition. Moreover, to test the efficacy of the HFS protocol, we quantified changes in mechanical pinprick sensitivity before and after HFS of the skin surrounding both electrodes. The perceived intensity was collected for both electrical and mechanical stimuli. After HFS, the perceived pain intensity elicited by the mechanical pinprick stimuli applied on the skin surrounding the HFS-treated site was significantly higher compared to control site (heterotopic effect). Furthermore, we found a higher perceived pain intensity for single electrical stimuli delivered to the HFS-treated site compared to the control site (homotopic effect). Whether the homotopic effect reflects a perceptual correlate of homosynaptic LTP remains to be elucidated.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173438
van de Broeke, Emanuel N.; Vanmaele, Tessa; Mouraux, André; Stouffs, Alexandre; Biurrun Manresa, José Alberto; et al.; Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study; The Royal Society; Royal Society Open Science; 8; 1; 1-2021; 1-13
2054-5703
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173438
identifier_str_mv van de Broeke, Emanuel N.; Vanmaele, Tessa; Mouraux, André; Stouffs, Alexandre; Biurrun Manresa, José Alberto; et al.; Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: A replication study; The Royal Society; Royal Society Open Science; 8; 1; 1-2021; 1-13
2054-5703
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1098/rsos.200830
info:eu-repo/semantics/altIdentifier/doi/10.1098/rsos.200830
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980609412038656
score 12.993085

Publicaciones similares