Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil

Autores
Bedoya Agudelo, Juan Pablo; López Carvajal, Jhon Esteban; Quiguanás Guarín, Edwin Stiven; Cardona, Nestor; Padilla Sanabria, Leonardo; Castaño Osorio, Jhon Carlos
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
(1) Introduction: Curcumin and Lippia origanoides essential oils have a broad spectrum of biological activities; however, their physicochemical instability, low solubility, and high volatility limit their therapeutic use. Encapsulation in liposomes has been reported as a feasible approach to increase the physicochemical stability of active substances, protect them from interactions with the environment, modulate their release, reduce their volatility, improve their bioactivity, and reduce their toxicity. To date, there are no reports on the co-encapsulation of curcumin and Lippia origanoides essential oils in liposomes. Therefore, the objective of this work is to prepare and physiochemical characterize liposomes loaded with the mixture of these compounds and to evaluate different in vitro biological activities. (2) Methods: Liposomes were produced using the thin-layer method and physiochemical characteristics were calculated. The antimicrobial and cytotoxic activities of both encapsulated and non-encapsulated compounds were evaluated. (3) Results: Empty and loaded nanometric-sized liposomes were obtained that are monodisperse and have a negative zeta potential. They inhibited the growth of Staphylococcus aureus and did not exhibit cytotoxic activity against mammalian cells. (4) Conclusions: Encapsulation in liposomes was demonstrated to be a promising strategy for natural compounds possessing antimicrobial activity.
Fil: Bedoya Agudelo, Juan Pablo. Universidad del Quindio; Colombia
Fil: López Carvajal, Jhon Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad del Quindio; Colombia
Fil: Quiguanás Guarín, Edwin Stiven. Universidad del Quindio; Colombia
Fil: Cardona, Nestor. Universidad Antonio Nariño; Colombia
Fil: Padilla Sanabria, Leonardo. Universidad del Quindio; Colombia
Fil: Castaño Osorio, Jhon Carlos. Universidad del Quindio; Colombia
Materia
LIPOSOME
LIPPIA ORIGANOIDES ESSENTIAL OIL
ANTIMICROBIAL
CITOTOXICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/257667
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/257667
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential OilBedoya Agudelo, Juan PabloLópez Carvajal, Jhon EstebanQuiguanás Guarín, Edwin StivenCardona, NestorPadilla Sanabria, LeonardoCastaño Osorio, Jhon CarlosLIPOSOMELIPPIA ORIGANOIDES ESSENTIAL OILANTIMICROBIALCITOTOXICITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3(1) Introduction: Curcumin and Lippia origanoides essential oils have a broad spectrum of biological activities; however, their physicochemical instability, low solubility, and high volatility limit their therapeutic use. Encapsulation in liposomes has been reported as a feasible approach to increase the physicochemical stability of active substances, protect them from interactions with the environment, modulate their release, reduce their volatility, improve their bioactivity, and reduce their toxicity. To date, there are no reports on the co-encapsulation of curcumin and Lippia origanoides essential oils in liposomes. Therefore, the objective of this work is to prepare and physiochemical characterize liposomes loaded with the mixture of these compounds and to evaluate different in vitro biological activities. (2) Methods: Liposomes were produced using the thin-layer method and physiochemical characteristics were calculated. The antimicrobial and cytotoxic activities of both encapsulated and non-encapsulated compounds were evaluated. (3) Results: Empty and loaded nanometric-sized liposomes were obtained that are monodisperse and have a negative zeta potential. They inhibited the growth of Staphylococcus aureus and did not exhibit cytotoxic activity against mammalian cells. (4) Conclusions: Encapsulation in liposomes was demonstrated to be a promising strategy for natural compounds possessing antimicrobial activity.Fil: Bedoya Agudelo, Juan Pablo. Universidad del Quindio; ColombiaFil: López Carvajal, Jhon Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad del Quindio; ColombiaFil: Quiguanás Guarín, Edwin Stiven. Universidad del Quindio; ColombiaFil: Cardona, Nestor. Universidad Antonio Nariño; ColombiaFil: Padilla Sanabria, Leonardo. Universidad del Quindio; ColombiaFil: Castaño Osorio, Jhon Carlos. Universidad del Quindio; ColombiaMultidisciplinary Digital Publishing Institute2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/257667Bedoya Agudelo, Juan Pablo; López Carvajal, Jhon Esteban; Quiguanás Guarín, Edwin Stiven; Cardona, Nestor; Padilla Sanabria, Leonardo; et al.; Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil; Multidisciplinary Digital Publishing Institute; Biomolecules; 14; 7; 7-2024; 1-192218-273XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-273X/14/7/851info:eu-repo/semantics/altIdentifier/doi/10.3390/biom14070851info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:57Zoai:ri.conicet.gov.ar:11336/257667instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:57.276CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil
title Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil
spellingShingle Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil
Bedoya Agudelo, Juan Pablo
LIPOSOME
LIPPIA ORIGANOIDES ESSENTIAL OIL
ANTIMICROBIAL
CITOTOXICITY
title_short Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil
title_full Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil
title_fullStr Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil
title_full_unstemmed Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil
title_sort Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil
dc.creator.none.fl_str_mv Bedoya Agudelo, Juan Pablo
López Carvajal, Jhon Esteban
Quiguanás Guarín, Edwin Stiven
Cardona, Nestor
Padilla Sanabria, Leonardo
Castaño Osorio, Jhon Carlos
author Bedoya Agudelo, Juan Pablo
author_facet Bedoya Agudelo, Juan Pablo
López Carvajal, Jhon Esteban
Quiguanás Guarín, Edwin Stiven
Cardona, Nestor
Padilla Sanabria, Leonardo
Castaño Osorio, Jhon Carlos
author_role author
author2 López Carvajal, Jhon Esteban
Quiguanás Guarín, Edwin Stiven
Cardona, Nestor
Padilla Sanabria, Leonardo
Castaño Osorio, Jhon Carlos
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv LIPOSOME
LIPPIA ORIGANOIDES ESSENTIAL OIL
ANTIMICROBIAL
CITOTOXICITY
topic LIPOSOME
LIPPIA ORIGANOIDES ESSENTIAL OIL
ANTIMICROBIAL
CITOTOXICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv (1) Introduction: Curcumin and Lippia origanoides essential oils have a broad spectrum of biological activities; however, their physicochemical instability, low solubility, and high volatility limit their therapeutic use. Encapsulation in liposomes has been reported as a feasible approach to increase the physicochemical stability of active substances, protect them from interactions with the environment, modulate their release, reduce their volatility, improve their bioactivity, and reduce their toxicity. To date, there are no reports on the co-encapsulation of curcumin and Lippia origanoides essential oils in liposomes. Therefore, the objective of this work is to prepare and physiochemical characterize liposomes loaded with the mixture of these compounds and to evaluate different in vitro biological activities. (2) Methods: Liposomes were produced using the thin-layer method and physiochemical characteristics were calculated. The antimicrobial and cytotoxic activities of both encapsulated and non-encapsulated compounds were evaluated. (3) Results: Empty and loaded nanometric-sized liposomes were obtained that are monodisperse and have a negative zeta potential. They inhibited the growth of Staphylococcus aureus and did not exhibit cytotoxic activity against mammalian cells. (4) Conclusions: Encapsulation in liposomes was demonstrated to be a promising strategy for natural compounds possessing antimicrobial activity.
Fil: Bedoya Agudelo, Juan Pablo. Universidad del Quindio; Colombia
Fil: López Carvajal, Jhon Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad del Quindio; Colombia
Fil: Quiguanás Guarín, Edwin Stiven. Universidad del Quindio; Colombia
Fil: Cardona, Nestor. Universidad Antonio Nariño; Colombia
Fil: Padilla Sanabria, Leonardo. Universidad del Quindio; Colombia
Fil: Castaño Osorio, Jhon Carlos. Universidad del Quindio; Colombia
description (1) Introduction: Curcumin and Lippia origanoides essential oils have a broad spectrum of biological activities; however, their physicochemical instability, low solubility, and high volatility limit their therapeutic use. Encapsulation in liposomes has been reported as a feasible approach to increase the physicochemical stability of active substances, protect them from interactions with the environment, modulate their release, reduce their volatility, improve their bioactivity, and reduce their toxicity. To date, there are no reports on the co-encapsulation of curcumin and Lippia origanoides essential oils in liposomes. Therefore, the objective of this work is to prepare and physiochemical characterize liposomes loaded with the mixture of these compounds and to evaluate different in vitro biological activities. (2) Methods: Liposomes were produced using the thin-layer method and physiochemical characteristics were calculated. The antimicrobial and cytotoxic activities of both encapsulated and non-encapsulated compounds were evaluated. (3) Results: Empty and loaded nanometric-sized liposomes were obtained that are monodisperse and have a negative zeta potential. They inhibited the growth of Staphylococcus aureus and did not exhibit cytotoxic activity against mammalian cells. (4) Conclusions: Encapsulation in liposomes was demonstrated to be a promising strategy for natural compounds possessing antimicrobial activity.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/257667
Bedoya Agudelo, Juan Pablo; López Carvajal, Jhon Esteban; Quiguanás Guarín, Edwin Stiven; Cardona, Nestor; Padilla Sanabria, Leonardo; et al.; Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil; Multidisciplinary Digital Publishing Institute; Biomolecules; 14; 7; 7-2024; 1-19
2218-273X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/257667
identifier_str_mv Bedoya Agudelo, Juan Pablo; López Carvajal, Jhon Esteban; Quiguanás Guarín, Edwin Stiven; Cardona, Nestor; Padilla Sanabria, Leonardo; et al.; Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil; Multidisciplinary Digital Publishing Institute; Biomolecules; 14; 7; 7-2024; 1-19
2218-273X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-273X/14/7/851
info:eu-repo/semantics/altIdentifier/doi/10.3390/biom14070851
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613085135896576
score 13.070432

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