Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity

Autores
Asensio Regalado, Carlos; Alonso Salces, Rosa Maria; Gallo, Blanca; Berrueta, Luis A.; Era, Benedetta; Pintus, Francesca; Caddeo, Carla
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polyphenols are gaining increasing interest due to their beneficial properties to human health. Grape pomace, the by-product of wine production, is a source of these bioactive compounds. An extract from Tempranillo grape pomace was obtained and characterized qualitatively and quantitatively. The major components found were anthocyanins, flavan-3-ols, and flavonols. To improve the bioavailability of these compounds, the extract was formulated in phospholipid vesicles, namely transfersomes. Spherical unilamellar vesicles around 100 nm each were obtained. The antioxidant activity of both the extract and the transfersomes was evaluated by using colorimetric assays (i.e., DPPH, FRAP, and Folin–Ciocalteu). The cells’ viability and the antioxidant activity were assessed in keratinocytes. The results showed that the extract and the transfersomes had no cytotoxic effects and exerted remarkable antioxidant activity, which was more evident in a vesicle formulation. These findings highlighted the potential of the Tempranillo grape pomace extract and the efficacy of the incorporation into phospholipid vesicles.
Fil: Asensio Regalado, Carlos. Universidad del País Vasco; España
Fil: Alonso Salces, Rosa Maria. Universidad Nacional de Mar del Plata. Instituto de Investigaciones en Producción, Sanidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Producción, Sanidad y Ambiente; Argentina
Fil: Gallo, Blanca. Universidad del País Vasco; España
Fil: Berrueta, Luis A.. Universidad del País Vasco; España
Fil: Era, Benedetta. Università Degli Studi Di Cagliari.; Italia
Fil: Pintus, Francesca. Università Degli Studi Di Cagliari.; Italia
Fil: Caddeo, Carla. Università Degli Studi Di Cagliari.; Italia
Materia
ANTIOXIDANT
GRAPE POMACE EXTRACT
PHOSPHOLIPID VESICLES
SKIN CELLS
SKIN DELIVERY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/170547
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activityAsensio Regalado, CarlosAlonso Salces, Rosa MariaGallo, BlancaBerrueta, Luis A.Era, BenedettaPintus, FrancescaCaddeo, CarlaANTIOXIDANTGRAPE POMACE EXTRACTPHOSPHOLIPID VESICLESSKIN CELLSSKIN DELIVERYhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Polyphenols are gaining increasing interest due to their beneficial properties to human health. Grape pomace, the by-product of wine production, is a source of these bioactive compounds. An extract from Tempranillo grape pomace was obtained and characterized qualitatively and quantitatively. The major components found were anthocyanins, flavan-3-ols, and flavonols. To improve the bioavailability of these compounds, the extract was formulated in phospholipid vesicles, namely transfersomes. Spherical unilamellar vesicles around 100 nm each were obtained. The antioxidant activity of both the extract and the transfersomes was evaluated by using colorimetric assays (i.e., DPPH, FRAP, and Folin–Ciocalteu). The cells’ viability and the antioxidant activity were assessed in keratinocytes. The results showed that the extract and the transfersomes had no cytotoxic effects and exerted remarkable antioxidant activity, which was more evident in a vesicle formulation. These findings highlighted the potential of the Tempranillo grape pomace extract and the efficacy of the incorporation into phospholipid vesicles.Fil: Asensio Regalado, Carlos. Universidad del País Vasco; EspañaFil: Alonso Salces, Rosa Maria. Universidad Nacional de Mar del Plata. Instituto de Investigaciones en Producción, Sanidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Producción, Sanidad y Ambiente; ArgentinaFil: Gallo, Blanca. Universidad del País Vasco; EspañaFil: Berrueta, Luis A.. Universidad del País Vasco; EspañaFil: Era, Benedetta. Università Degli Studi Di Cagliari.; ItaliaFil: Pintus, Francesca. Università Degli Studi Di Cagliari.; ItaliaFil: Caddeo, Carla. Università Degli Studi Di Cagliari.; ItaliaMDPI2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170547Asensio Regalado, Carlos; Alonso Salces, Rosa Maria; Gallo, Blanca; Berrueta, Luis A.; Era, Benedetta; et al.; Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity; MDPI; Nanomaterials; 12; 5; 2-2022; 1-112079-4991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/12/5/746info:eu-repo/semantics/altIdentifier/doi/10.3390/nano12050746info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:25:05Zoai:ri.conicet.gov.ar:11336/170547instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:25:05.331CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity
title Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity
spellingShingle Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity
Asensio Regalado, Carlos
ANTIOXIDANT
GRAPE POMACE EXTRACT
PHOSPHOLIPID VESICLES
SKIN CELLS
SKIN DELIVERY
title_short Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity
title_full Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity
title_fullStr Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity
title_full_unstemmed Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity
title_sort Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity
dc.creator.none.fl_str_mv Asensio Regalado, Carlos
Alonso Salces, Rosa Maria
Gallo, Blanca
Berrueta, Luis A.
Era, Benedetta
Pintus, Francesca
Caddeo, Carla
author Asensio Regalado, Carlos
author_facet Asensio Regalado, Carlos
Alonso Salces, Rosa Maria
Gallo, Blanca
Berrueta, Luis A.
Era, Benedetta
Pintus, Francesca
Caddeo, Carla
author_role author
author2 Alonso Salces, Rosa Maria
Gallo, Blanca
Berrueta, Luis A.
Era, Benedetta
Pintus, Francesca
Caddeo, Carla
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIOXIDANT
GRAPE POMACE EXTRACT
PHOSPHOLIPID VESICLES
SKIN CELLS
SKIN DELIVERY
topic ANTIOXIDANT
GRAPE POMACE EXTRACT
PHOSPHOLIPID VESICLES
SKIN CELLS
SKIN DELIVERY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Polyphenols are gaining increasing interest due to their beneficial properties to human health. Grape pomace, the by-product of wine production, is a source of these bioactive compounds. An extract from Tempranillo grape pomace was obtained and characterized qualitatively and quantitatively. The major components found were anthocyanins, flavan-3-ols, and flavonols. To improve the bioavailability of these compounds, the extract was formulated in phospholipid vesicles, namely transfersomes. Spherical unilamellar vesicles around 100 nm each were obtained. The antioxidant activity of both the extract and the transfersomes was evaluated by using colorimetric assays (i.e., DPPH, FRAP, and Folin–Ciocalteu). The cells’ viability and the antioxidant activity were assessed in keratinocytes. The results showed that the extract and the transfersomes had no cytotoxic effects and exerted remarkable antioxidant activity, which was more evident in a vesicle formulation. These findings highlighted the potential of the Tempranillo grape pomace extract and the efficacy of the incorporation into phospholipid vesicles.
Fil: Asensio Regalado, Carlos. Universidad del País Vasco; España
Fil: Alonso Salces, Rosa Maria. Universidad Nacional de Mar del Plata. Instituto de Investigaciones en Producción, Sanidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Producción, Sanidad y Ambiente; Argentina
Fil: Gallo, Blanca. Universidad del País Vasco; España
Fil: Berrueta, Luis A.. Universidad del País Vasco; España
Fil: Era, Benedetta. Università Degli Studi Di Cagliari.; Italia
Fil: Pintus, Francesca. Università Degli Studi Di Cagliari.; Italia
Fil: Caddeo, Carla. Università Degli Studi Di Cagliari.; Italia
description Polyphenols are gaining increasing interest due to their beneficial properties to human health. Grape pomace, the by-product of wine production, is a source of these bioactive compounds. An extract from Tempranillo grape pomace was obtained and characterized qualitatively and quantitatively. The major components found were anthocyanins, flavan-3-ols, and flavonols. To improve the bioavailability of these compounds, the extract was formulated in phospholipid vesicles, namely transfersomes. Spherical unilamellar vesicles around 100 nm each were obtained. The antioxidant activity of both the extract and the transfersomes was evaluated by using colorimetric assays (i.e., DPPH, FRAP, and Folin–Ciocalteu). The cells’ viability and the antioxidant activity were assessed in keratinocytes. The results showed that the extract and the transfersomes had no cytotoxic effects and exerted remarkable antioxidant activity, which was more evident in a vesicle formulation. These findings highlighted the potential of the Tempranillo grape pomace extract and the efficacy of the incorporation into phospholipid vesicles.
publishDate 2022
dc.date.none.fl_str_mv 2022-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/170547
Asensio Regalado, Carlos; Alonso Salces, Rosa Maria; Gallo, Blanca; Berrueta, Luis A.; Era, Benedetta; et al.; Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity; MDPI; Nanomaterials; 12; 5; 2-2022; 1-11
2079-4991
CONICET Digital
CONICET
url http://hdl.handle.net/11336/170547
identifier_str_mv Asensio Regalado, Carlos; Alonso Salces, Rosa Maria; Gallo, Blanca; Berrueta, Luis A.; Era, Benedetta; et al.; Tempranillo grape extract in transfersomes: A nanoproduct with antioxidant activity; MDPI; Nanomaterials; 12; 5; 2-2022; 1-11
2079-4991
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/12/5/746
info:eu-repo/semantics/altIdentifier/doi/10.3390/nano12050746
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981392333406208
score 12.48226

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