Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems

Autores
Garnero, Claudia; Chattah, Ana Karina; Longhi, Marcela Raquel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We present new supramolecular complexes of two different solid forms of furosemide (I or II) with maltodextrin, in order to explore their application as delivery systems improving the bioavailability of the drug. The complexation in solution was evaluated by 1H nuclear magnetic resonance experiments and phase solubility studies. The products in solid state were exhaustively characterized by using spectroscopic techniques (13C solid state nuclear magnetic resonance, infrared, scanning electron microscopy, X-ray powder diffractometry) and thermal analysis. 1H relaxation times experiments gave further support in distinguishing the new solid forms. Dissolution studies in simulated gastric fluid showed that both supramolecular complexes presented significant increase in the dissolution, while the corresponding physical mixtures exhibited the most discriminating conditions between the furosemide forms I and II. Our results suggest the enhancement of the solubility and the dissolution of furosemide in the new complexes, making them promising candidates for the preparation of alternative matrices in oral pharmaceutical formulations.
Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Furosemide
Polymorphism
Solubility
Complex Characterization
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24873
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systemsGarnero, ClaudiaChattah, Ana KarinaLonghi, Marcela RaquelFurosemidePolymorphismSolubilityComplex Characterizationhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1We present new supramolecular complexes of two different solid forms of furosemide (I or II) with maltodextrin, in order to explore their application as delivery systems improving the bioavailability of the drug. The complexation in solution was evaluated by 1H nuclear magnetic resonance experiments and phase solubility studies. The products in solid state were exhaustively characterized by using spectroscopic techniques (13C solid state nuclear magnetic resonance, infrared, scanning electron microscopy, X-ray powder diffractometry) and thermal analysis. 1H relaxation times experiments gave further support in distinguishing the new solid forms. Dissolution studies in simulated gastric fluid showed that both supramolecular complexes presented significant increase in the dissolution, while the corresponding physical mixtures exhibited the most discriminating conditions between the furosemide forms I and II. Our results suggest the enhancement of the solubility and the dissolution of furosemide in the new complexes, making them promising candidates for the preparation of alternative matrices in oral pharmaceutical formulations.Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24873Garnero, Claudia; Chattah, Ana Karina; Longhi, Marcela Raquel; Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems; Elsevier; Carbohydrate Polymers; 94; 1; 1-2013; 292-3000144-8617CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2013.01.055info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0144861713000726info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:57Zoai:ri.conicet.gov.ar:11336/24873instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:57.673CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems
title Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems
spellingShingle Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems
Garnero, Claudia
Furosemide
Polymorphism
Solubility
Complex Characterization
title_short Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems
title_full Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems
title_fullStr Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems
title_full_unstemmed Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems
title_sort Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems
dc.creator.none.fl_str_mv Garnero, Claudia
Chattah, Ana Karina
Longhi, Marcela Raquel
author Garnero, Claudia
author_facet Garnero, Claudia
Chattah, Ana Karina
Longhi, Marcela Raquel
author_role author
author2 Chattah, Ana Karina
Longhi, Marcela Raquel
author2_role author
author
dc.subject.none.fl_str_mv Furosemide
Polymorphism
Solubility
Complex Characterization
topic Furosemide
Polymorphism
Solubility
Complex Characterization
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We present new supramolecular complexes of two different solid forms of furosemide (I or II) with maltodextrin, in order to explore their application as delivery systems improving the bioavailability of the drug. The complexation in solution was evaluated by 1H nuclear magnetic resonance experiments and phase solubility studies. The products in solid state were exhaustively characterized by using spectroscopic techniques (13C solid state nuclear magnetic resonance, infrared, scanning electron microscopy, X-ray powder diffractometry) and thermal analysis. 1H relaxation times experiments gave further support in distinguishing the new solid forms. Dissolution studies in simulated gastric fluid showed that both supramolecular complexes presented significant increase in the dissolution, while the corresponding physical mixtures exhibited the most discriminating conditions between the furosemide forms I and II. Our results suggest the enhancement of the solubility and the dissolution of furosemide in the new complexes, making them promising candidates for the preparation of alternative matrices in oral pharmaceutical formulations.
Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description We present new supramolecular complexes of two different solid forms of furosemide (I or II) with maltodextrin, in order to explore their application as delivery systems improving the bioavailability of the drug. The complexation in solution was evaluated by 1H nuclear magnetic resonance experiments and phase solubility studies. The products in solid state were exhaustively characterized by using spectroscopic techniques (13C solid state nuclear magnetic resonance, infrared, scanning electron microscopy, X-ray powder diffractometry) and thermal analysis. 1H relaxation times experiments gave further support in distinguishing the new solid forms. Dissolution studies in simulated gastric fluid showed that both supramolecular complexes presented significant increase in the dissolution, while the corresponding physical mixtures exhibited the most discriminating conditions between the furosemide forms I and II. Our results suggest the enhancement of the solubility and the dissolution of furosemide in the new complexes, making them promising candidates for the preparation of alternative matrices in oral pharmaceutical formulations.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24873
Garnero, Claudia; Chattah, Ana Karina; Longhi, Marcela Raquel; Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems; Elsevier; Carbohydrate Polymers; 94; 1; 1-2013; 292-300
0144-8617
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24873
identifier_str_mv Garnero, Claudia; Chattah, Ana Karina; Longhi, Marcela Raquel; Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems; Elsevier; Carbohydrate Polymers; 94; 1; 1-2013; 292-300
0144-8617
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2013.01.055
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0144861713000726
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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