Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease

Autores
Martín Giménez, Virna Margarita; Noriega, Sandra; Kassuha, Diego Enrique; Fuentes, Lucia Beatriz; Manucha, Walter Ariel Fernando
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Noriega, Sandra. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kassuha, Diego Enrique. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fuentes, Lucia Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
ANANDAMIDE
CARDIOVASCULAR DISEASE
CB1 RECEPTORS
ENDOCANNABINOID SYSTEM
NITRIC OXIDE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/90685
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular diseaseMartín Giménez, Virna MargaritaNoriega, SandraKassuha, Diego EnriqueFuentes, Lucia BeatrizManucha, Walter Ariel FernandoANANDAMIDECARDIOVASCULAR DISEASECB1 RECEPTORSENDOCANNABINOID SYSTEMNITRIC OXIDEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Noriega, Sandra. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kassuha, Diego Enrique. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fuentes, Lucia Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaSAGE Publications2018-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/90685Martín Giménez, Virna Margarita; Noriega, Sandra; Kassuha, Diego Enrique; Fuentes, Lucia Beatriz; Manucha, Walter Ariel Fernando; Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease; SAGE Publications; Therapeutic Advances in Cardiovascular Disease; 12; 7; 7-2018; 177-1901753-9455CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/1753944718773690info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/1753944718773690info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:42Zoai:ri.conicet.gov.ar:11336/90685instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:42.633CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
title Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
spellingShingle Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
Martín Giménez, Virna Margarita
ANANDAMIDE
CARDIOVASCULAR DISEASE
CB1 RECEPTORS
ENDOCANNABINOID SYSTEM
NITRIC OXIDE
title_short Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
title_full Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
title_fullStr Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
title_full_unstemmed Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
title_sort Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
dc.creator.none.fl_str_mv Martín Giménez, Virna Margarita
Noriega, Sandra
Kassuha, Diego Enrique
Fuentes, Lucia Beatriz
Manucha, Walter Ariel Fernando
author Martín Giménez, Virna Margarita
author_facet Martín Giménez, Virna Margarita
Noriega, Sandra
Kassuha, Diego Enrique
Fuentes, Lucia Beatriz
Manucha, Walter Ariel Fernando
author_role author
author2 Noriega, Sandra
Kassuha, Diego Enrique
Fuentes, Lucia Beatriz
Manucha, Walter Ariel Fernando
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANANDAMIDE
CARDIOVASCULAR DISEASE
CB1 RECEPTORS
ENDOCANNABINOID SYSTEM
NITRIC OXIDE
topic ANANDAMIDE
CARDIOVASCULAR DISEASE
CB1 RECEPTORS
ENDOCANNABINOID SYSTEM
NITRIC OXIDE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Noriega, Sandra. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kassuha, Diego Enrique. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fuentes, Lucia Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.
publishDate 2018
dc.date.none.fl_str_mv 2018-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/90685
Martín Giménez, Virna Margarita; Noriega, Sandra; Kassuha, Diego Enrique; Fuentes, Lucia Beatriz; Manucha, Walter Ariel Fernando; Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease; SAGE Publications; Therapeutic Advances in Cardiovascular Disease; 12; 7; 7-2018; 177-190
1753-9455
CONICET Digital
CONICET
url http://hdl.handle.net/11336/90685
identifier_str_mv Martín Giménez, Virna Margarita; Noriega, Sandra; Kassuha, Diego Enrique; Fuentes, Lucia Beatriz; Manucha, Walter Ariel Fernando; Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease; SAGE Publications; Therapeutic Advances in Cardiovascular Disease; 12; 7; 7-2018; 177-190
1753-9455
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/1753944718773690
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/1753944718773690
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269477856608256
score 13.13397

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