Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy

Autores
Zarelli, Valeria Eugenia Paola; Giai, Constanza; Colombo, Maria Isabel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic. The pathogenesis of the disease is based on its ability to multiply and survive within phagocytic cells of the host, particularly macrophages and monocytes. The majority (90 %) of infected humans have a ?latent infection?, meaning they efficiently contain but do not spread the bacteria; they are infected but asymptomatic and not contagious. However the remaining 10 % have a lifetime risk of reactivating the infection and developing active tuberculosis (Sakamoto, 2012). The great destructive impact on public health, the co-infection with the human immunodeficiency virus (HIV) and the appearance of drug resistant strains of Mtb are demanding the development of new tools for prevention and treatment.During the last decade a greater understanding on the human immune response to Mtb infection as well as the contribution of factors linked to the pathogenesis of the disease has been achieved. Although the knowledge about the human immune response against Mtb as well as the contribution of factors linked to the pathogenesis of the disease have markedly increased in the last year, a deeper understanding of its immunopathogenesis will lead to the identification of new drugs and the development of effective vaccines.
Fil: Zarelli, Valeria Eugenia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Giai, Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Materia
Tuberculosis
Host-pathogenl interaction
Trafficking
Autophagy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99179
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagyZarelli, Valeria Eugenia PaolaGiai, ConstanzaColombo, Maria IsabelTuberculosisHost-pathogenl interactionTraffickingAutophagyhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic. The pathogenesis of the disease is based on its ability to multiply and survive within phagocytic cells of the host, particularly macrophages and monocytes. The majority (90 %) of infected humans have a ?latent infection?, meaning they efficiently contain but do not spread the bacteria; they are infected but asymptomatic and not contagious. However the remaining 10 % have a lifetime risk of reactivating the infection and developing active tuberculosis (Sakamoto, 2012). The great destructive impact on public health, the co-infection with the human immunodeficiency virus (HIV) and the appearance of drug resistant strains of Mtb are demanding the development of new tools for prevention and treatment.During the last decade a greater understanding on the human immune response to Mtb infection as well as the contribution of factors linked to the pathogenesis of the disease has been achieved. Although the knowledge about the human immune response against Mtb as well as the contribution of factors linked to the pathogenesis of the disease have markedly increased in the last year, a deeper understanding of its immunopathogenesis will lead to the identification of new drugs and the development of effective vaccines.Fil: Zarelli, Valeria Eugenia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Giai, Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaSM Group2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99179Zarelli, Valeria Eugenia Paola; Giai, Constanza; Colombo, Maria Isabel; Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy; SM Group; 2018; 1-16978-1-944685-00-3CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://smjournals.com/ebooks/tuberculosis/chapters/TB-18-19.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:07:23Zoai:ri.conicet.gov.ar:11336/99179instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:07:23.259CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy
title Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy
spellingShingle Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy
Zarelli, Valeria Eugenia Paola
Tuberculosis
Host-pathogenl interaction
Trafficking
Autophagy
title_short Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy
title_full Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy
title_fullStr Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy
title_full_unstemmed Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy
title_sort Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy
dc.creator.none.fl_str_mv Zarelli, Valeria Eugenia Paola
Giai, Constanza
Colombo, Maria Isabel
author Zarelli, Valeria Eugenia Paola
author_facet Zarelli, Valeria Eugenia Paola
Giai, Constanza
Colombo, Maria Isabel
author_role author
author2 Giai, Constanza
Colombo, Maria Isabel
author2_role author
author
dc.subject.none.fl_str_mv Tuberculosis
Host-pathogenl interaction
Trafficking
Autophagy
topic Tuberculosis
Host-pathogenl interaction
Trafficking
Autophagy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic. The pathogenesis of the disease is based on its ability to multiply and survive within phagocytic cells of the host, particularly macrophages and monocytes. The majority (90 %) of infected humans have a ?latent infection?, meaning they efficiently contain but do not spread the bacteria; they are infected but asymptomatic and not contagious. However the remaining 10 % have a lifetime risk of reactivating the infection and developing active tuberculosis (Sakamoto, 2012). The great destructive impact on public health, the co-infection with the human immunodeficiency virus (HIV) and the appearance of drug resistant strains of Mtb are demanding the development of new tools for prevention and treatment.During the last decade a greater understanding on the human immune response to Mtb infection as well as the contribution of factors linked to the pathogenesis of the disease has been achieved. Although the knowledge about the human immune response against Mtb as well as the contribution of factors linked to the pathogenesis of the disease have markedly increased in the last year, a deeper understanding of its immunopathogenesis will lead to the identification of new drugs and the development of effective vaccines.
Fil: Zarelli, Valeria Eugenia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Giai, Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
description Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic. The pathogenesis of the disease is based on its ability to multiply and survive within phagocytic cells of the host, particularly macrophages and monocytes. The majority (90 %) of infected humans have a ?latent infection?, meaning they efficiently contain but do not spread the bacteria; they are infected but asymptomatic and not contagious. However the remaining 10 % have a lifetime risk of reactivating the infection and developing active tuberculosis (Sakamoto, 2012). The great destructive impact on public health, the co-infection with the human immunodeficiency virus (HIV) and the appearance of drug resistant strains of Mtb are demanding the development of new tools for prevention and treatment.During the last decade a greater understanding on the human immune response to Mtb infection as well as the contribution of factors linked to the pathogenesis of the disease has been achieved. Although the knowledge about the human immune response against Mtb as well as the contribution of factors linked to the pathogenesis of the disease have markedly increased in the last year, a deeper understanding of its immunopathogenesis will lead to the identification of new drugs and the development of effective vaccines.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/bookPart
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
status_str publishedVersion
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99179
Zarelli, Valeria Eugenia Paola; Giai, Constanza; Colombo, Maria Isabel; Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy; SM Group; 2018; 1-16
978-1-944685-00-3
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99179
identifier_str_mv Zarelli, Valeria Eugenia Paola; Giai, Constanza; Colombo, Maria Isabel; Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy; SM Group; 2018; 1-16
978-1-944685-00-3
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://smjournals.com/ebooks/tuberculosis/chapters/TB-18-19.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SM Group
publisher.none.fl_str_mv SM Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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