Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias

Autores
Delfino, M.A.; Stefano, A.V.; Ferrario, Juan Esteban; Taravini, Irene Rita Eloisa; Murer, Mario Gustavo; Gershanik, O.S.
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Repeated treatment with dopamine (DA) receptor agonists strongly potentiates contralateral turning behavior due to selective stimulation of D1 or D2-class receptors in 6-hydroxydopamine (6-OHDA)-lesioned rats. This phenomenon, referred to as sensitization, is believed to be related to the motor response complications (dyskinesias, on-off states) that occur during chronic administration of levodopa in Parkinson’s disease patients. In recent years a new method for the evaluation of abnormal involuntary movements (AIMs) secondary to dopaminergic stimulation in 6-OHDA-lesioned rats was described. These AIMs resemble dyskinesias as seen in parkinsonian patients under levodopa therapy. Our objective was to evaluate the effects of repeated treatment with different regimes of DA agonists on turning behavior and on an AIMs scale in 6-OHDA lesioned rats, with the aim of discriminating between drugs with different dyskinesia-inducing potential. In addition, we explored the effects of a previous exposure to a DA agonist (priming) on the behavioral response to the subsequent administration of a DA agonist with the same or different pharmacologic profile. Our results show that in apomorphine-treated rats, rotational behavior and AIMs run a parallel course of enhancement, while in those receiving quinpirole there is a dissociation, suggesting that they could be mediated by different mechanisms. The finding of a significant priming effect on subsequent testing of 6-OHDA lesioned rats should be borne in mind as the use of these pharmacological tests in the screening of well lesioned animals could lead to an erroneous interpretation of further results on dyskinesias and rotational behavior.
Fil: Delfino MA. ININFA; Argentina. ININFA; Argentina
Fil: Stefano AV. ININFA; Argentina
Fil: Ferrario, Juan Esteban. ININFA; Argentina
Fil: Taravini, Irene Rita Eloisa. ININFA; Argentina
Fil: Murer, Mario Gustavo. FACULTAD DE MEDICINA; Argentina
Fil: Gershanik OS. ININFA; Argentina
Materia
6-OHDA-LESIONED RATS
ABNORMAL INVOLUNTARY MOVEMENTS
PARKINSON'S DISEASE
PRIMING
ROTATIONAL BEHAVIOR
SENSITIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94391
Acceder
id CONICETDig_fc31b7f9edd388890a66bb9d947c9983
oai_identifier_str oai:ri.conicet.gov.ar:11336/94391
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesiasDelfino, M.A.Stefano, A.V.Ferrario, Juan EstebanTaravini, Irene Rita EloisaMurer, Mario GustavoGershanik, O.S.6-OHDA-LESIONED RATSABNORMAL INVOLUNTARY MOVEMENTSPARKINSON'S DISEASEPRIMINGROTATIONAL BEHAVIORSENSITIZATIONhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Repeated treatment with dopamine (DA) receptor agonists strongly potentiates contralateral turning behavior due to selective stimulation of D1 or D2-class receptors in 6-hydroxydopamine (6-OHDA)-lesioned rats. This phenomenon, referred to as sensitization, is believed to be related to the motor response complications (dyskinesias, on-off states) that occur during chronic administration of levodopa in Parkinson’s disease patients. In recent years a new method for the evaluation of abnormal involuntary movements (AIMs) secondary to dopaminergic stimulation in 6-OHDA-lesioned rats was described. These AIMs resemble dyskinesias as seen in parkinsonian patients under levodopa therapy. Our objective was to evaluate the effects of repeated treatment with different regimes of DA agonists on turning behavior and on an AIMs scale in 6-OHDA lesioned rats, with the aim of discriminating between drugs with different dyskinesia-inducing potential. In addition, we explored the effects of a previous exposure to a DA agonist (priming) on the behavioral response to the subsequent administration of a DA agonist with the same or different pharmacologic profile. Our results show that in apomorphine-treated rats, rotational behavior and AIMs run a parallel course of enhancement, while in those receiving quinpirole there is a dissociation, suggesting that they could be mediated by different mechanisms. The finding of a significant priming effect on subsequent testing of 6-OHDA lesioned rats should be borne in mind as the use of these pharmacological tests in the screening of well lesioned animals could lead to an erroneous interpretation of further results on dyskinesias and rotational behavior.Fil: Delfino MA. ININFA; Argentina. ININFA; ArgentinaFil: Stefano AV. ININFA; ArgentinaFil: Ferrario, Juan Esteban. ININFA; ArgentinaFil: Taravini, Irene Rita Eloisa. ININFA; ArgentinaFil: Murer, Mario Gustavo. FACULTAD DE MEDICINA; ArgentinaFil: Gershanik OS. ININFA; ArgentinaElsevier Science2004-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94391Delfino, M.A.; Stefano, A.V.; Ferrario, Juan Esteban; Taravini, Irene Rita Eloisa; Murer, Mario Gustavo; et al.; Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias; Elsevier Science; Behavioural Brain Research; 152; 2; 7-2004; 297-3060166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432803003735info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2003.10.009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:32Zoai:ri.conicet.gov.ar:11336/94391instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:32.571CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
title Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
spellingShingle Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
Delfino, M.A.
6-OHDA-LESIONED RATS
ABNORMAL INVOLUNTARY MOVEMENTS
PARKINSON'S DISEASE
PRIMING
ROTATIONAL BEHAVIOR
SENSITIZATION
title_short Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
title_full Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
title_fullStr Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
title_full_unstemmed Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
title_sort Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
dc.creator.none.fl_str_mv Delfino, M.A.
Stefano, A.V.
Ferrario, Juan Esteban
Taravini, Irene Rita Eloisa
Murer, Mario Gustavo
Gershanik, O.S.
author Delfino, M.A.
author_facet Delfino, M.A.
Stefano, A.V.
Ferrario, Juan Esteban
Taravini, Irene Rita Eloisa
Murer, Mario Gustavo
Gershanik, O.S.
author_role author
author2 Stefano, A.V.
Ferrario, Juan Esteban
Taravini, Irene Rita Eloisa
Murer, Mario Gustavo
Gershanik, O.S.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv 6-OHDA-LESIONED RATS
ABNORMAL INVOLUNTARY MOVEMENTS
PARKINSON'S DISEASE
PRIMING
ROTATIONAL BEHAVIOR
SENSITIZATION
topic 6-OHDA-LESIONED RATS
ABNORMAL INVOLUNTARY MOVEMENTS
PARKINSON'S DISEASE
PRIMING
ROTATIONAL BEHAVIOR
SENSITIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Repeated treatment with dopamine (DA) receptor agonists strongly potentiates contralateral turning behavior due to selective stimulation of D1 or D2-class receptors in 6-hydroxydopamine (6-OHDA)-lesioned rats. This phenomenon, referred to as sensitization, is believed to be related to the motor response complications (dyskinesias, on-off states) that occur during chronic administration of levodopa in Parkinson’s disease patients. In recent years a new method for the evaluation of abnormal involuntary movements (AIMs) secondary to dopaminergic stimulation in 6-OHDA-lesioned rats was described. These AIMs resemble dyskinesias as seen in parkinsonian patients under levodopa therapy. Our objective was to evaluate the effects of repeated treatment with different regimes of DA agonists on turning behavior and on an AIMs scale in 6-OHDA lesioned rats, with the aim of discriminating between drugs with different dyskinesia-inducing potential. In addition, we explored the effects of a previous exposure to a DA agonist (priming) on the behavioral response to the subsequent administration of a DA agonist with the same or different pharmacologic profile. Our results show that in apomorphine-treated rats, rotational behavior and AIMs run a parallel course of enhancement, while in those receiving quinpirole there is a dissociation, suggesting that they could be mediated by different mechanisms. The finding of a significant priming effect on subsequent testing of 6-OHDA lesioned rats should be borne in mind as the use of these pharmacological tests in the screening of well lesioned animals could lead to an erroneous interpretation of further results on dyskinesias and rotational behavior.
Fil: Delfino MA. ININFA; Argentina. ININFA; Argentina
Fil: Stefano AV. ININFA; Argentina
Fil: Ferrario, Juan Esteban. ININFA; Argentina
Fil: Taravini, Irene Rita Eloisa. ININFA; Argentina
Fil: Murer, Mario Gustavo. FACULTAD DE MEDICINA; Argentina
Fil: Gershanik OS. ININFA; Argentina
description Repeated treatment with dopamine (DA) receptor agonists strongly potentiates contralateral turning behavior due to selective stimulation of D1 or D2-class receptors in 6-hydroxydopamine (6-OHDA)-lesioned rats. This phenomenon, referred to as sensitization, is believed to be related to the motor response complications (dyskinesias, on-off states) that occur during chronic administration of levodopa in Parkinson’s disease patients. In recent years a new method for the evaluation of abnormal involuntary movements (AIMs) secondary to dopaminergic stimulation in 6-OHDA-lesioned rats was described. These AIMs resemble dyskinesias as seen in parkinsonian patients under levodopa therapy. Our objective was to evaluate the effects of repeated treatment with different regimes of DA agonists on turning behavior and on an AIMs scale in 6-OHDA lesioned rats, with the aim of discriminating between drugs with different dyskinesia-inducing potential. In addition, we explored the effects of a previous exposure to a DA agonist (priming) on the behavioral response to the subsequent administration of a DA agonist with the same or different pharmacologic profile. Our results show that in apomorphine-treated rats, rotational behavior and AIMs run a parallel course of enhancement, while in those receiving quinpirole there is a dissociation, suggesting that they could be mediated by different mechanisms. The finding of a significant priming effect on subsequent testing of 6-OHDA lesioned rats should be borne in mind as the use of these pharmacological tests in the screening of well lesioned animals could lead to an erroneous interpretation of further results on dyskinesias and rotational behavior.
publishDate 2004
dc.date.none.fl_str_mv 2004-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94391
Delfino, M.A.; Stefano, A.V.; Ferrario, Juan Esteban; Taravini, Irene Rita Eloisa; Murer, Mario Gustavo; et al.; Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias; Elsevier Science; Behavioural Brain Research; 152; 2; 7-2004; 297-306
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94391
identifier_str_mv Delfino, M.A.; Stefano, A.V.; Ferrario, Juan Esteban; Taravini, Irene Rita Eloisa; Murer, Mario Gustavo; et al.; Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias; Elsevier Science; Behavioural Brain Research; 152; 2; 7-2004; 297-306
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432803003735
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2003.10.009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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