Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice

Autores
Zambrana Infantes, Emma; Rosell del Valle, Cristina; Ladrón de Guevara Miranda, David; Galeano, Pablo; Castilla Ortega, Estela; Rodríguez De Fonseca, Fernando; Blanco, Eduardo; Santín, Luis Javier
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cocaine addiction is a chronically relapsing disorder characterized by compulsive drug-seeking and drug-taking behaviors. Previous studies have demonstrated that cocaine, as well as other drugs of abuse, alters the levels of lipid-based signaling molecules, such as N-acylethanolamines (NAEs). Moreover, brain levels of NAEs have shown sensitivity to cocaine self-administration and extinction training in rodents. Given this background, the aim of this study was to investigate the effects of repeated or acute administration of palmitoylethanolamide (PEA), an endogenous NAE, on psychomotor sensitization and cocaine-induced contextual conditioning. To this end, the potential ability of repeated PEA administration (1 or 10 mg/kg, i.p.) to modulate the acquisition of cocaine-induced behavioral sensitization (BS) and conditioned place preference (CPP) was assessed in male C57BL/6J mice. In addition, the expression of cocaine-induced BS and CPP following acute PEA administration were also studied. Results showed that repeated administration of both doses of PEA were able to block the acquisition of cocaine-induced BS. Furthermore, acute administration of both doses of PEA was able to abolish the expression of BS, while the highest dose also abolished the expression of cocaine-induced CPP. Taken together, these results indicate that exogenous administration of PEA attenuated psychomotor sensitization, while the effect of PEA in cocaine-induced CPP depended on whether PEA was administered repeatedly or acutely. These findings could be relevant to understand the role that NAEs play in processes underlying the development and maintenance of cocaine addiction.
Fil: Zambrana Infantes, Emma. Universidad de Málaga; España
Fil: Rosell del Valle, Cristina. Universidad de Málaga; España
Fil: Ladrón de Guevara Miranda, David. Universidad de Málaga; España
Fil: Galeano, Pablo. Universidad de Málaga; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Castilla Ortega, Estela. Hospital Regional Universitario de Málaga; España
Fil: Rodríguez De Fonseca, Fernando. Hospital Regional Universitario de Málaga; España
Fil: Blanco, Eduardo. Universidad de Lleida; España
Fil: Santín, Luis Javier. Universidad de Málaga; España
Materia
COCAINE
CONDITIONED LOCOMOTION
CONDITIONED PLACE PREFERENCE
LOCOMOTOR SENSITIZATION
PALMITOYLETHANOLAMIDE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/151289
Acceder
id CONICETDig_1f4553a9df9356f9cd6588280aae0c28
oai_identifier_str oai:ri.conicet.gov.ar:11336/151289
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in miceZambrana Infantes, EmmaRosell del Valle, CristinaLadrón de Guevara Miranda, DavidGaleano, PabloCastilla Ortega, EstelaRodríguez De Fonseca, FernandoBlanco, EduardoSantín, Luis JavierCOCAINECONDITIONED LOCOMOTIONCONDITIONED PLACE PREFERENCELOCOMOTOR SENSITIZATIONPALMITOYLETHANOLAMIDEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cocaine addiction is a chronically relapsing disorder characterized by compulsive drug-seeking and drug-taking behaviors. Previous studies have demonstrated that cocaine, as well as other drugs of abuse, alters the levels of lipid-based signaling molecules, such as N-acylethanolamines (NAEs). Moreover, brain levels of NAEs have shown sensitivity to cocaine self-administration and extinction training in rodents. Given this background, the aim of this study was to investigate the effects of repeated or acute administration of palmitoylethanolamide (PEA), an endogenous NAE, on psychomotor sensitization and cocaine-induced contextual conditioning. To this end, the potential ability of repeated PEA administration (1 or 10 mg/kg, i.p.) to modulate the acquisition of cocaine-induced behavioral sensitization (BS) and conditioned place preference (CPP) was assessed in male C57BL/6J mice. In addition, the expression of cocaine-induced BS and CPP following acute PEA administration were also studied. Results showed that repeated administration of both doses of PEA were able to block the acquisition of cocaine-induced BS. Furthermore, acute administration of both doses of PEA was able to abolish the expression of BS, while the highest dose also abolished the expression of cocaine-induced CPP. Taken together, these results indicate that exogenous administration of PEA attenuated psychomotor sensitization, while the effect of PEA in cocaine-induced CPP depended on whether PEA was administered repeatedly or acutely. These findings could be relevant to understand the role that NAEs play in processes underlying the development and maintenance of cocaine addiction.Fil: Zambrana Infantes, Emma. Universidad de Málaga; EspañaFil: Rosell del Valle, Cristina. Universidad de Málaga; EspañaFil: Ladrón de Guevara Miranda, David. Universidad de Málaga; EspañaFil: Galeano, Pablo. Universidad de Málaga; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Castilla Ortega, Estela. Hospital Regional Universitario de Málaga; EspañaFil: Rodríguez De Fonseca, Fernando. Hospital Regional Universitario de Málaga; EspañaFil: Blanco, Eduardo. Universidad de Lleida; EspañaFil: Santín, Luis Javier. Universidad de Málaga; EspañaPergamon-Elsevier Science Ltd2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/151289Zambrana Infantes, Emma; Rosell del Valle, Cristina; Ladrón de Guevara Miranda, David; Galeano, Pablo; Castilla Ortega, Estela; et al.; Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice; Pergamon-Elsevier Science Ltd; Pharmacology Biochemistry and Behavior; 166; 3-2018; 1-580091-30571873-5177CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0091305717305981info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pbb.2018.01.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:09:47Zoai:ri.conicet.gov.ar:11336/151289instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:09:48.036CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
title Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
spellingShingle Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
Zambrana Infantes, Emma
COCAINE
CONDITIONED LOCOMOTION
CONDITIONED PLACE PREFERENCE
LOCOMOTOR SENSITIZATION
PALMITOYLETHANOLAMIDE
title_short Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
title_full Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
title_fullStr Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
title_full_unstemmed Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
title_sort Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
dc.creator.none.fl_str_mv Zambrana Infantes, Emma
Rosell del Valle, Cristina
Ladrón de Guevara Miranda, David
Galeano, Pablo
Castilla Ortega, Estela
Rodríguez De Fonseca, Fernando
Blanco, Eduardo
Santín, Luis Javier
author Zambrana Infantes, Emma
author_facet Zambrana Infantes, Emma
Rosell del Valle, Cristina
Ladrón de Guevara Miranda, David
Galeano, Pablo
Castilla Ortega, Estela
Rodríguez De Fonseca, Fernando
Blanco, Eduardo
Santín, Luis Javier
author_role author
author2 Rosell del Valle, Cristina
Ladrón de Guevara Miranda, David
Galeano, Pablo
Castilla Ortega, Estela
Rodríguez De Fonseca, Fernando
Blanco, Eduardo
Santín, Luis Javier
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COCAINE
CONDITIONED LOCOMOTION
CONDITIONED PLACE PREFERENCE
LOCOMOTOR SENSITIZATION
PALMITOYLETHANOLAMIDE
topic COCAINE
CONDITIONED LOCOMOTION
CONDITIONED PLACE PREFERENCE
LOCOMOTOR SENSITIZATION
PALMITOYLETHANOLAMIDE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cocaine addiction is a chronically relapsing disorder characterized by compulsive drug-seeking and drug-taking behaviors. Previous studies have demonstrated that cocaine, as well as other drugs of abuse, alters the levels of lipid-based signaling molecules, such as N-acylethanolamines (NAEs). Moreover, brain levels of NAEs have shown sensitivity to cocaine self-administration and extinction training in rodents. Given this background, the aim of this study was to investigate the effects of repeated or acute administration of palmitoylethanolamide (PEA), an endogenous NAE, on psychomotor sensitization and cocaine-induced contextual conditioning. To this end, the potential ability of repeated PEA administration (1 or 10 mg/kg, i.p.) to modulate the acquisition of cocaine-induced behavioral sensitization (BS) and conditioned place preference (CPP) was assessed in male C57BL/6J mice. In addition, the expression of cocaine-induced BS and CPP following acute PEA administration were also studied. Results showed that repeated administration of both doses of PEA were able to block the acquisition of cocaine-induced BS. Furthermore, acute administration of both doses of PEA was able to abolish the expression of BS, while the highest dose also abolished the expression of cocaine-induced CPP. Taken together, these results indicate that exogenous administration of PEA attenuated psychomotor sensitization, while the effect of PEA in cocaine-induced CPP depended on whether PEA was administered repeatedly or acutely. These findings could be relevant to understand the role that NAEs play in processes underlying the development and maintenance of cocaine addiction.
Fil: Zambrana Infantes, Emma. Universidad de Málaga; España
Fil: Rosell del Valle, Cristina. Universidad de Málaga; España
Fil: Ladrón de Guevara Miranda, David. Universidad de Málaga; España
Fil: Galeano, Pablo. Universidad de Málaga; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Castilla Ortega, Estela. Hospital Regional Universitario de Málaga; España
Fil: Rodríguez De Fonseca, Fernando. Hospital Regional Universitario de Málaga; España
Fil: Blanco, Eduardo. Universidad de Lleida; España
Fil: Santín, Luis Javier. Universidad de Málaga; España
description Cocaine addiction is a chronically relapsing disorder characterized by compulsive drug-seeking and drug-taking behaviors. Previous studies have demonstrated that cocaine, as well as other drugs of abuse, alters the levels of lipid-based signaling molecules, such as N-acylethanolamines (NAEs). Moreover, brain levels of NAEs have shown sensitivity to cocaine self-administration and extinction training in rodents. Given this background, the aim of this study was to investigate the effects of repeated or acute administration of palmitoylethanolamide (PEA), an endogenous NAE, on psychomotor sensitization and cocaine-induced contextual conditioning. To this end, the potential ability of repeated PEA administration (1 or 10 mg/kg, i.p.) to modulate the acquisition of cocaine-induced behavioral sensitization (BS) and conditioned place preference (CPP) was assessed in male C57BL/6J mice. In addition, the expression of cocaine-induced BS and CPP following acute PEA administration were also studied. Results showed that repeated administration of both doses of PEA were able to block the acquisition of cocaine-induced BS. Furthermore, acute administration of both doses of PEA was able to abolish the expression of BS, while the highest dose also abolished the expression of cocaine-induced CPP. Taken together, these results indicate that exogenous administration of PEA attenuated psychomotor sensitization, while the effect of PEA in cocaine-induced CPP depended on whether PEA was administered repeatedly or acutely. These findings could be relevant to understand the role that NAEs play in processes underlying the development and maintenance of cocaine addiction.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/151289
Zambrana Infantes, Emma; Rosell del Valle, Cristina; Ladrón de Guevara Miranda, David; Galeano, Pablo; Castilla Ortega, Estela; et al.; Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice; Pergamon-Elsevier Science Ltd; Pharmacology Biochemistry and Behavior; 166; 3-2018; 1-58
0091-3057
1873-5177
CONICET Digital
CONICET
url http://hdl.handle.net/11336/151289
identifier_str_mv Zambrana Infantes, Emma; Rosell del Valle, Cristina; Ladrón de Guevara Miranda, David; Galeano, Pablo; Castilla Ortega, Estela; et al.; Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice; Pergamon-Elsevier Science Ltd; Pharmacology Biochemistry and Behavior; 166; 3-2018; 1-58
0091-3057
1873-5177
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0091305717305981
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pbb.2018.01.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980485836308480
score 12.993085

Publicaciones similares