Ferroptosis in health and disease

• Autores: Berndt, Carsten; Alborzinia, Hamed; Amen, Vera Skafar; Ayton, Scott; Barayeu, Uladzimir; Bartelt, Alexander; Bayir, Hülya; Bebber, Christina M.; Birsoy, Kivanc; Böttcher, Jan P.; Brabletz, Simone; Brabletz, Thomas; Brown, Ashley R.; Brunner Bernhardt, Mauricio Andrés; Bulli, Giorgia; Bruneau, Alix; Chen, Quan; DeNicola, Gina M.; Dick, Tobias P.; Distefano, Ayelen Mariana; Dixon, Scott J.; Engler, Jan B.; Pagnussat, Gabriela Carolina; Wilhelm, Christoph; Wölk, Michele; Wu, Katherine; Yang, Xin; Yu, Fan; Zou, Yilong; Conrad, Marcus
• Año de publicación: 2024
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: CELL DEATH; LIPID PEROXIDATION; IRON; ISCHEMIA/REPERFUSION; CANCER; NEURODEGENERATION
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells’ susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets for the treatment of numerous currently incurable diseases. Herein, the current members of a Germany-wide research consortium focusing on ferroptosis research, as well as key external experts in ferroptosis who have made seminal contributions to this rapidly growing and exciting field of research, have gathered to provide a comprehensive, state-of-the-art review on ferroptosis. Specific topics include: basic mechanisms, in vivo relevance, specialized methodologies, chemical and pharmacological tools, and the potential contribution of ferroptosis to disease etiopathology and progression. We hope that this article will not only provide established scientists and newcomers to the field with an overview of the multiple facets of ferroptosis, but also encourage additional efforts to characterize further molecular pathways modulating ferroptosis, with the ultimate goal to develop novel pharmacotherapies to tackle the various diseases associated with – or caused by – ferroptosis.
Fil: Berndt, Carsten. Heinrich-Heine University; Alemania
Fil: Alborzinia, Hamed. Heidelberg Institute for Stem Cell Technology and Experimental Medicine; Alemania
Fil: Amen, Vera Skafar. University of Würzburg; Alemania
Fil: Ayton, Scott. University of Melbourne; Australia
Fil: Barayeu, Uladzimir. Heidelberg University; Alemania. German Cancer Research Center; Alemania. Tohoku University Graduate School of Medicine; Japón
Fil: Bartelt, Alexander. Ludwig Maximilians Universitat; Alemania
Fil: Bayir, Hülya. Columbia University; Estados Unidos
Fil: Bebber, Christina M.. University of Cologne; Alemania
Fil: Birsoy, Kivanc. The Rockefeller University; Estados Unidos
Fil: Böttcher, Jan P.. Universitat Technical Zu Munich; Alemania
Fil: Brabletz, Simone. Friedrich-Alexander University of Erlangen-Nürnberg; Alemania
Fil: Brabletz, Thomas. Friedrich-Alexander University of Erlangen-Nürnberg; Alemania
Fil: Brown, Ashley R.. Columbia University; Estados Unidos
Fil: Brunner Bernhardt, Mauricio Andrés. Goethe Universitat Frankfurt; Alemania
Fil: Bulli, Giorgia. Ludwig Maximilians Universitat; Alemania
Fil: Bruneau, Alix. Goethe Universitat Frankfurt; Alemania
Fil: Chen, Quan. Nankai University; China
Fil: DeNicola, Gina M.. Moffitt Cancer Center; Estados Unidos
Fil: Dick, Tobias P.. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Distefano, Ayelen Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Dixon, Scott J.. University of Stanford; Estados Unidos
Fil: Engler, Jan B.. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Pagnussat, Gabriela Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Wilhelm, Christoph. Universitat Bonn; Alemania
Fil: Wölk, Michele. University Hospital Carl Gustav Carus; Alemania
Fil: Wu, Katherine. University of New York; Estados Unidos
Fil: Yang, Xin. Columbia University; Estados Unidos
Fil: Yu, Fan. Nankai University; China
Fil: Zou, Yilong. Westlake University; China
Fil: Conrad, Marcus. Helmholtz Center Munich; Alemania