VIP and tolerance induction in autoimmunity

Autores
Rosignoli, F.; Torroba, M.; Juarranz, Y.; García Gómez, M.; Martinez, C.; Gomariz, R. P.; Perez Leiros, Claudia; Leceta, J.
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells.
Fil: Rosignoli, F.. Universidad Complutense de Madrid; España
Fil: Torroba, M.. Universidad Complutense de Madrid; España
Fil: Juarranz, Y.. Universidad Complutense de Madrid; España
Fil: García Gómez, M.. Universidad Complutense de Madrid; España
Fil: Martinez, C.. Universidad Complutense de Madrid; España
Fil: Gomariz, R. P.. Universidad Complutense de Madrid; España
Fil: Perez Leiros, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Leceta, J.. Universidad Complutense de Madrid; España
Materia
AUTOIMMUNE
FOXP3
TGF-Β
VIP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99385
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/99385
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling VIP and tolerance induction in autoimmunityRosignoli, F.Torroba, M.Juarranz, Y.García Gómez, M.Martinez, C.Gomariz, R. P.Perez Leiros, ClaudiaLeceta, J.AUTOIMMUNEFOXP3TGF-ΒVIPhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells.Fil: Rosignoli, F.. Universidad Complutense de Madrid; EspañaFil: Torroba, M.. Universidad Complutense de Madrid; EspañaFil: Juarranz, Y.. Universidad Complutense de Madrid; EspañaFil: García Gómez, M.. Universidad Complutense de Madrid; EspañaFil: Martinez, C.. Universidad Complutense de Madrid; EspañaFil: Gomariz, R. P.. Universidad Complutense de Madrid; EspañaFil: Perez Leiros, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Leceta, J.. Universidad Complutense de Madrid; EspañaBlackwell Publishing2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99385Rosignoli, F.; Torroba, M.; Juarranz, Y.; García Gómez, M.; Martinez, C.; et al.; VIP and tolerance induction in autoimmunity; Blackwell Publishing; Annals of the New York Academy of Sciences; 1070; 12-2006; 525-5300077-8923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1317.073info:eu-repo/semantics/altIdentifier/doi/10.1196/annals.1317.073info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:23:03Zoai:ri.conicet.gov.ar:11336/99385instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:03.792CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv VIP and tolerance induction in autoimmunity
title VIP and tolerance induction in autoimmunity
spellingShingle VIP and tolerance induction in autoimmunity
Rosignoli, F.
AUTOIMMUNE
FOXP3
TGF-Β
VIP
title_short VIP and tolerance induction in autoimmunity
title_full VIP and tolerance induction in autoimmunity
title_fullStr VIP and tolerance induction in autoimmunity
title_full_unstemmed VIP and tolerance induction in autoimmunity
title_sort VIP and tolerance induction in autoimmunity
dc.creator.none.fl_str_mv Rosignoli, F.
Torroba, M.
Juarranz, Y.
García Gómez, M.
Martinez, C.
Gomariz, R. P.
Perez Leiros, Claudia
Leceta, J.
author Rosignoli, F.
author_facet Rosignoli, F.
Torroba, M.
Juarranz, Y.
García Gómez, M.
Martinez, C.
Gomariz, R. P.
Perez Leiros, Claudia
Leceta, J.
author_role author
author2 Torroba, M.
Juarranz, Y.
García Gómez, M.
Martinez, C.
Gomariz, R. P.
Perez Leiros, Claudia
Leceta, J.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AUTOIMMUNE
FOXP3
TGF-Β
VIP
topic AUTOIMMUNE
FOXP3
TGF-Β
VIP
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells.
Fil: Rosignoli, F.. Universidad Complutense de Madrid; España
Fil: Torroba, M.. Universidad Complutense de Madrid; España
Fil: Juarranz, Y.. Universidad Complutense de Madrid; España
Fil: García Gómez, M.. Universidad Complutense de Madrid; España
Fil: Martinez, C.. Universidad Complutense de Madrid; España
Fil: Gomariz, R. P.. Universidad Complutense de Madrid; España
Fil: Perez Leiros, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Leceta, J.. Universidad Complutense de Madrid; España
description Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99385
Rosignoli, F.; Torroba, M.; Juarranz, Y.; García Gómez, M.; Martinez, C.; et al.; VIP and tolerance induction in autoimmunity; Blackwell Publishing; Annals of the New York Academy of Sciences; 1070; 12-2006; 525-530
0077-8923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99385
identifier_str_mv Rosignoli, F.; Torroba, M.; Juarranz, Y.; García Gómez, M.; Martinez, C.; et al.; VIP and tolerance induction in autoimmunity; Blackwell Publishing; Annals of the New York Academy of Sciences; 1070; 12-2006; 525-530
0077-8923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1317.073
info:eu-repo/semantics/altIdentifier/doi/10.1196/annals.1317.073
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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