Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films

Autores
Caracciolo, Pablo Christian; Buffa, Juan Manuel; Thomas, Vinoy; Vohra, Yogesh K.; Abraham, Gustavo Abel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development of elastomeric bioresorbable and biocompatible segmented polyurethanes (SPU) for use in tissue engineering applications has been a subject of considerable interest in recent years. In this work, non-porous films and micro/nanofibrous scaffolds prepared from two different poly(ε-caprolactone)-based SPU previously synthesized using 1,6-hexamethylene diisocyanate and novel chain extenders containing urea groups or an aromatic aminoacid derivative, were studied. Thermal properties were influenced both by the different chemical structure of the hard segments and the processing conditions. Mechanical properties of the scaffolds showed elastic moludus, ultimate strain and tensile stress values adecuate for soft-tissue engineered constructs (i.e.: myocardial tissue). Film samples displayed low swelling degree (less than 2 wt %) in phosphate-buffered solution (PBS) at 37 ºC. The introduction of the aminoacid derivative chain extender with hydrolyzable ester bonds contributed to a higher degradation. Fibrous scaffolds exhibited higher hydrolytic stability than films at short times of assay, due to their more crystalline structures and higher degrees of association by hydrogen bonding, but also higher mass loss values in accelerated conditions (70 ºC), suggesting that degradation rate is not constant but depends on the degradation time and the processing technique.
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
Fil: Buffa, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
Fil: Thomas, Vinoy. University Of Alabama At Birmingahm; Estados Unidos
Fil: Vohra, Yogesh K.. University Of Alabama At Birmingahm; Estados Unidos
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
Materia
Nanofibers
Scaffold
Thermal Properties
Mechanical Properties
Degradation
Polyurethanes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16030
Acceder
id CONICETDig_fafb45a60709d1906fca5628b9424724
oai_identifier_str oai:ri.conicet.gov.ar:11336/16030
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Biodegradable polyurethanes: Comparative study of electrospun scaffolds and filmsCaracciolo, Pablo ChristianBuffa, Juan ManuelThomas, VinoyVohra, Yogesh K.Abraham, Gustavo AbelNanofibersScaffoldThermal PropertiesMechanical PropertiesDegradationPolyurethaneshttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2The development of elastomeric bioresorbable and biocompatible segmented polyurethanes (SPU) for use in tissue engineering applications has been a subject of considerable interest in recent years. In this work, non-porous films and micro/nanofibrous scaffolds prepared from two different poly(ε-caprolactone)-based SPU previously synthesized using 1,6-hexamethylene diisocyanate and novel chain extenders containing urea groups or an aromatic aminoacid derivative, were studied. Thermal properties were influenced both by the different chemical structure of the hard segments and the processing conditions. Mechanical properties of the scaffolds showed elastic moludus, ultimate strain and tensile stress values adecuate for soft-tissue engineered constructs (i.e.: myocardial tissue). Film samples displayed low swelling degree (less than 2 wt %) in phosphate-buffered solution (PBS) at 37 ºC. The introduction of the aminoacid derivative chain extender with hydrolyzable ester bonds contributed to a higher degradation. Fibrous scaffolds exhibited higher hydrolytic stability than films at short times of assay, due to their more crystalline structures and higher degrees of association by hydrogen bonding, but also higher mass loss values in accelerated conditions (70 ºC), suggesting that degradation rate is not constant but depends on the degradation time and the processing technique.Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; ArgentinaFil: Buffa, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; ArgentinaFil: Thomas, Vinoy. University Of Alabama At Birmingahm; Estados UnidosFil: Vohra, Yogesh K.. University Of Alabama At Birmingahm; Estados UnidosFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; ArgentinaWiley2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16030Caracciolo, Pablo Christian; Buffa, Juan Manuel; Thomas, Vinoy; Vohra, Yogesh K.; Abraham, Gustavo Abel; Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films; Wiley; Journal Of Applied Polymer Science; 121; 6; 9-2011; 3292-32990021-8995enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/app.33855/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=info:eu-repo/semantics/altIdentifier/doi/10.1002/app.33855info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:21:37Zoai:ri.conicet.gov.ar:11336/16030instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:21:37.289CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
title Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
spellingShingle Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
Caracciolo, Pablo Christian
Nanofibers
Scaffold
Thermal Properties
Mechanical Properties
Degradation
Polyurethanes
title_short Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
title_full Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
title_fullStr Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
title_full_unstemmed Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
title_sort Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
dc.creator.none.fl_str_mv Caracciolo, Pablo Christian
Buffa, Juan Manuel
Thomas, Vinoy
Vohra, Yogesh K.
Abraham, Gustavo Abel
author Caracciolo, Pablo Christian
author_facet Caracciolo, Pablo Christian
Buffa, Juan Manuel
Thomas, Vinoy
Vohra, Yogesh K.
Abraham, Gustavo Abel
author_role author
author2 Buffa, Juan Manuel
Thomas, Vinoy
Vohra, Yogesh K.
Abraham, Gustavo Abel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Nanofibers
Scaffold
Thermal Properties
Mechanical Properties
Degradation
Polyurethanes
topic Nanofibers
Scaffold
Thermal Properties
Mechanical Properties
Degradation
Polyurethanes
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The development of elastomeric bioresorbable and biocompatible segmented polyurethanes (SPU) for use in tissue engineering applications has been a subject of considerable interest in recent years. In this work, non-porous films and micro/nanofibrous scaffolds prepared from two different poly(ε-caprolactone)-based SPU previously synthesized using 1,6-hexamethylene diisocyanate and novel chain extenders containing urea groups or an aromatic aminoacid derivative, were studied. Thermal properties were influenced both by the different chemical structure of the hard segments and the processing conditions. Mechanical properties of the scaffolds showed elastic moludus, ultimate strain and tensile stress values adecuate for soft-tissue engineered constructs (i.e.: myocardial tissue). Film samples displayed low swelling degree (less than 2 wt %) in phosphate-buffered solution (PBS) at 37 ºC. The introduction of the aminoacid derivative chain extender with hydrolyzable ester bonds contributed to a higher degradation. Fibrous scaffolds exhibited higher hydrolytic stability than films at short times of assay, due to their more crystalline structures and higher degrees of association by hydrogen bonding, but also higher mass loss values in accelerated conditions (70 ºC), suggesting that degradation rate is not constant but depends on the degradation time and the processing technique.
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
Fil: Buffa, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
Fil: Thomas, Vinoy. University Of Alabama At Birmingahm; Estados Unidos
Fil: Vohra, Yogesh K.. University Of Alabama At Birmingahm; Estados Unidos
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
description The development of elastomeric bioresorbable and biocompatible segmented polyurethanes (SPU) for use in tissue engineering applications has been a subject of considerable interest in recent years. In this work, non-porous films and micro/nanofibrous scaffolds prepared from two different poly(ε-caprolactone)-based SPU previously synthesized using 1,6-hexamethylene diisocyanate and novel chain extenders containing urea groups or an aromatic aminoacid derivative, were studied. Thermal properties were influenced both by the different chemical structure of the hard segments and the processing conditions. Mechanical properties of the scaffolds showed elastic moludus, ultimate strain and tensile stress values adecuate for soft-tissue engineered constructs (i.e.: myocardial tissue). Film samples displayed low swelling degree (less than 2 wt %) in phosphate-buffered solution (PBS) at 37 ºC. The introduction of the aminoacid derivative chain extender with hydrolyzable ester bonds contributed to a higher degradation. Fibrous scaffolds exhibited higher hydrolytic stability than films at short times of assay, due to their more crystalline structures and higher degrees of association by hydrogen bonding, but also higher mass loss values in accelerated conditions (70 ºC), suggesting that degradation rate is not constant but depends on the degradation time and the processing technique.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16030
Caracciolo, Pablo Christian; Buffa, Juan Manuel; Thomas, Vinoy; Vohra, Yogesh K.; Abraham, Gustavo Abel; Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films; Wiley; Journal Of Applied Polymer Science; 121; 6; 9-2011; 3292-3299
0021-8995
url http://hdl.handle.net/11336/16030
identifier_str_mv Caracciolo, Pablo Christian; Buffa, Juan Manuel; Thomas, Vinoy; Vohra, Yogesh K.; Abraham, Gustavo Abel; Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films; Wiley; Journal Of Applied Polymer Science; 121; 6; 9-2011; 3292-3299
0021-8995
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/app.33855/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=
info:eu-repo/semantics/altIdentifier/doi/10.1002/app.33855
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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