Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa

Autores
Kay, Elisabeth; Humair, Bérénice; Dénervaud, Valérie; Riedel, Kathrin; Spahr, Stéphanie; Eberl, Leo; Valverde, Claudio Fabián; Haas, Dieter
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In Pseudomonas aeruginosa, the GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ. An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD). Both mutants showed increased swarming ability, azurin release, and early biofilm development.
Fil: Kay, Elisabeth. Universite de Lausanne; Suiza
Fil: Humair, Bérénice. Universite de Lausanne; Suiza
Fil: Dénervaud, Valérie. Universite de Lausanne; Suiza
Fil: Riedel, Kathrin. Universitat Zurich; Suiza
Fil: Spahr, Stéphanie. Universite de Lausanne; Suiza
Fil: Eberl, Leo. Universitat Zurich; Suiza
Fil: Valverde, Claudio Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universite de Lausanne; Suiza
Fil: Haas, Dieter. Universite de Lausanne; Suiza
Materia
Pseudomonas aeruginosa
sRNAs
Gac/Rsm cascade
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/244796
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/244796
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosaKay, ElisabethHumair, BéréniceDénervaud, ValérieRiedel, KathrinSpahr, StéphanieEberl, LeoValverde, Claudio FabiánHaas, DieterPseudomonas aeruginosasRNAsGac/Rsm cascadehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In Pseudomonas aeruginosa, the GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ. An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD). Both mutants showed increased swarming ability, azurin release, and early biofilm development.Fil: Kay, Elisabeth. Universite de Lausanne; SuizaFil: Humair, Bérénice. Universite de Lausanne; SuizaFil: Dénervaud, Valérie. Universite de Lausanne; SuizaFil: Riedel, Kathrin. Universitat Zurich; SuizaFil: Spahr, Stéphanie. Universite de Lausanne; SuizaFil: Eberl, Leo. Universitat Zurich; SuizaFil: Valverde, Claudio Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universite de Lausanne; SuizaFil: Haas, Dieter. Universite de Lausanne; SuizaAmerican Society for Microbiology2006-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/244796Kay, Elisabeth; Humair, Bérénice; Dénervaud, Valérie; Riedel, Kathrin; Spahr, Stéphanie; et al.; Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa; American Society for Microbiology; Journal of Bacteriology; 188; 16; 8-2006; 6026-60330021-9193CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/jb.00409-06info:eu-repo/semantics/altIdentifier/doi/10.1128/JB.00409-06info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:13:59Zoai:ri.conicet.gov.ar:11336/244796instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:13:59.564CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa
title Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa
spellingShingle Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa
Kay, Elisabeth
Pseudomonas aeruginosa
sRNAs
Gac/Rsm cascade
title_short Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa
title_full Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa
title_fullStr Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa
title_full_unstemmed Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa
title_sort Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa
dc.creator.none.fl_str_mv Kay, Elisabeth
Humair, Bérénice
Dénervaud, Valérie
Riedel, Kathrin
Spahr, Stéphanie
Eberl, Leo
Valverde, Claudio Fabián
Haas, Dieter
author Kay, Elisabeth
author_facet Kay, Elisabeth
Humair, Bérénice
Dénervaud, Valérie
Riedel, Kathrin
Spahr, Stéphanie
Eberl, Leo
Valverde, Claudio Fabián
Haas, Dieter
author_role author
author2 Humair, Bérénice
Dénervaud, Valérie
Riedel, Kathrin
Spahr, Stéphanie
Eberl, Leo
Valverde, Claudio Fabián
Haas, Dieter
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pseudomonas aeruginosa
sRNAs
Gac/Rsm cascade
topic Pseudomonas aeruginosa
sRNAs
Gac/Rsm cascade
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In Pseudomonas aeruginosa, the GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ. An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD). Both mutants showed increased swarming ability, azurin release, and early biofilm development.
Fil: Kay, Elisabeth. Universite de Lausanne; Suiza
Fil: Humair, Bérénice. Universite de Lausanne; Suiza
Fil: Dénervaud, Valérie. Universite de Lausanne; Suiza
Fil: Riedel, Kathrin. Universitat Zurich; Suiza
Fil: Spahr, Stéphanie. Universite de Lausanne; Suiza
Fil: Eberl, Leo. Universitat Zurich; Suiza
Fil: Valverde, Claudio Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universite de Lausanne; Suiza
Fil: Haas, Dieter. Universite de Lausanne; Suiza
description In Pseudomonas aeruginosa, the GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ. An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD). Both mutants showed increased swarming ability, azurin release, and early biofilm development.
publishDate 2006
dc.date.none.fl_str_mv 2006-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/244796
Kay, Elisabeth; Humair, Bérénice; Dénervaud, Valérie; Riedel, Kathrin; Spahr, Stéphanie; et al.; Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa; American Society for Microbiology; Journal of Bacteriology; 188; 16; 8-2006; 6026-6033
0021-9193
CONICET Digital
CONICET
url http://hdl.handle.net/11336/244796
identifier_str_mv Kay, Elisabeth; Humair, Bérénice; Dénervaud, Valérie; Riedel, Kathrin; Spahr, Stéphanie; et al.; Two GacA-Dependent Small RNAs Modulate the Quorum-Sensing Response in Pseudomonas aeruginosa; American Society for Microbiology; Journal of Bacteriology; 188; 16; 8-2006; 6026-6033
0021-9193
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/jb.00409-06
info:eu-repo/semantics/altIdentifier/doi/10.1128/JB.00409-06
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980743847870464
score 12.993085

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