Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

Autores
Bianchi, María Beatrice; Zhang, Chunyang; Catlin, Elise; Sandri, Giuseppina; Calderón, Marcelo; Larrañeta, Eneko; Donnelly, Ryan F.; Picchio, Matías Luis; Paredes, Alejandro Javier
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are attracting a great deal of interest in the biomedical space. Herein, we report the first example of adhesive Egels loading drug nanocrystals (Egel-NCs) for controlled delivery to mucosal tissues. These soft materials were prepared using gelatin, glycerine, a deep eutectic solvent (DES) based on choline hydrochloride and glycerol, and nanocrystallised curcumin, a model drug with potent antimicrobial and anti-inflammatory activities. We first explored the impact of the biopolymer concentration on the viscoelastic and mechanical properties of the networks. Thanks to the dynamic interactions between gelatin and the DES, the Egel showed excellent stretchability and elasticity (up to ≈160%), reversible gel-sol phase transition at mild temperature (≈50 ​°C), 3D-printing ability, and good adhesion to mucin protein (stickiness ≈40 ​kPa). In vitro release profiles demonstrated the ability of the NCs-based Egel to deliver curcumin for up to four weeks and deposit significantly higher drug amounts in excised porcine mucosa compared to the control cohort. All in all, this study opens new prospects in designing soft adhesive materials for long-acting drug delivery and paves the way to explore novel eutectic systems with multiple therapeutic applications.
Fil: Bianchi, María Beatrice. The Queens University of Belfast; Irlanda. Universita degli Studi di Pavia; Italia
Fil: Zhang, Chunyang. The Queens University of Belfast; Irlanda
Fil: Catlin, Elise. The Queens University of Belfast; Irlanda
Fil: Sandri, Giuseppina. Universita degli Studi di Pavia; Italia
Fil: Calderón, Marcelo. Ikerbasque, Basque Foundation For Science; España. Universidad del País Vasco; España
Fil: Larrañeta, Eneko. The Queens University of Belfast; Irlanda
Fil: Donnelly, Ryan F.. The Queens University of Belfast; Irlanda
Fil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad del País Vasco; España
Fil: Paredes, Alejandro Javier. The Queens University of Belfast; Irlanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
3D PRINTING
BIOADHESION
CURCUMIN
DRUG DELIVERY
EUTECTOGELS
NANOCRYSTALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/218520
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/218520
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissuesBianchi, María BeatriceZhang, ChunyangCatlin, EliseSandri, GiuseppinaCalderón, MarceloLarrañeta, EnekoDonnelly, Ryan F.Picchio, Matías LuisParedes, Alejandro Javier3D PRINTINGBIOADHESIONCURCUMINDRUG DELIVERYEUTECTOGELSNANOCRYSTALShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are attracting a great deal of interest in the biomedical space. Herein, we report the first example of adhesive Egels loading drug nanocrystals (Egel-NCs) for controlled delivery to mucosal tissues. These soft materials were prepared using gelatin, glycerine, a deep eutectic solvent (DES) based on choline hydrochloride and glycerol, and nanocrystallised curcumin, a model drug with potent antimicrobial and anti-inflammatory activities. We first explored the impact of the biopolymer concentration on the viscoelastic and mechanical properties of the networks. Thanks to the dynamic interactions between gelatin and the DES, the Egel showed excellent stretchability and elasticity (up to ≈160%), reversible gel-sol phase transition at mild temperature (≈50 ​°C), 3D-printing ability, and good adhesion to mucin protein (stickiness ≈40 ​kPa). In vitro release profiles demonstrated the ability of the NCs-based Egel to deliver curcumin for up to four weeks and deposit significantly higher drug amounts in excised porcine mucosa compared to the control cohort. All in all, this study opens new prospects in designing soft adhesive materials for long-acting drug delivery and paves the way to explore novel eutectic systems with multiple therapeutic applications.Fil: Bianchi, María Beatrice. The Queens University of Belfast; Irlanda. Universita degli Studi di Pavia; ItaliaFil: Zhang, Chunyang. The Queens University of Belfast; IrlandaFil: Catlin, Elise. The Queens University of Belfast; IrlandaFil: Sandri, Giuseppina. Universita degli Studi di Pavia; ItaliaFil: Calderón, Marcelo. Ikerbasque, Basque Foundation For Science; España. Universidad del País Vasco; EspañaFil: Larrañeta, Eneko. The Queens University of Belfast; IrlandaFil: Donnelly, Ryan F.. The Queens University of Belfast; IrlandaFil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad del País Vasco; EspañaFil: Paredes, Alejandro Javier. The Queens University of Belfast; Irlanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaElsevier2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218520Bianchi, María Beatrice; Zhang, Chunyang; Catlin, Elise; Sandri, Giuseppina; Calderón, Marcelo; et al.; Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues; Elsevier; Materials Today Bio; 17; 100471; 12-2022; 1-132590-0064CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.mtbio.2022.100471info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2590006422002691info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:37Zoai:ri.conicet.gov.ar:11336/218520instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:38.044CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
title Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
spellingShingle Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
Bianchi, María Beatrice
3D PRINTING
BIOADHESION
CURCUMIN
DRUG DELIVERY
EUTECTOGELS
NANOCRYSTALS
title_short Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
title_full Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
title_fullStr Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
title_full_unstemmed Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
title_sort Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
dc.creator.none.fl_str_mv Bianchi, María Beatrice
Zhang, Chunyang
Catlin, Elise
Sandri, Giuseppina
Calderón, Marcelo
Larrañeta, Eneko
Donnelly, Ryan F.
Picchio, Matías Luis
Paredes, Alejandro Javier
author Bianchi, María Beatrice
author_facet Bianchi, María Beatrice
Zhang, Chunyang
Catlin, Elise
Sandri, Giuseppina
Calderón, Marcelo
Larrañeta, Eneko
Donnelly, Ryan F.
Picchio, Matías Luis
Paredes, Alejandro Javier
author_role author
author2 Zhang, Chunyang
Catlin, Elise
Sandri, Giuseppina
Calderón, Marcelo
Larrañeta, Eneko
Donnelly, Ryan F.
Picchio, Matías Luis
Paredes, Alejandro Javier
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 3D PRINTING
BIOADHESION
CURCUMIN
DRUG DELIVERY
EUTECTOGELS
NANOCRYSTALS
topic 3D PRINTING
BIOADHESION
CURCUMIN
DRUG DELIVERY
EUTECTOGELS
NANOCRYSTALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are attracting a great deal of interest in the biomedical space. Herein, we report the first example of adhesive Egels loading drug nanocrystals (Egel-NCs) for controlled delivery to mucosal tissues. These soft materials were prepared using gelatin, glycerine, a deep eutectic solvent (DES) based on choline hydrochloride and glycerol, and nanocrystallised curcumin, a model drug with potent antimicrobial and anti-inflammatory activities. We first explored the impact of the biopolymer concentration on the viscoelastic and mechanical properties of the networks. Thanks to the dynamic interactions between gelatin and the DES, the Egel showed excellent stretchability and elasticity (up to ≈160%), reversible gel-sol phase transition at mild temperature (≈50 ​°C), 3D-printing ability, and good adhesion to mucin protein (stickiness ≈40 ​kPa). In vitro release profiles demonstrated the ability of the NCs-based Egel to deliver curcumin for up to four weeks and deposit significantly higher drug amounts in excised porcine mucosa compared to the control cohort. All in all, this study opens new prospects in designing soft adhesive materials for long-acting drug delivery and paves the way to explore novel eutectic systems with multiple therapeutic applications.
Fil: Bianchi, María Beatrice. The Queens University of Belfast; Irlanda. Universita degli Studi di Pavia; Italia
Fil: Zhang, Chunyang. The Queens University of Belfast; Irlanda
Fil: Catlin, Elise. The Queens University of Belfast; Irlanda
Fil: Sandri, Giuseppina. Universita degli Studi di Pavia; Italia
Fil: Calderón, Marcelo. Ikerbasque, Basque Foundation For Science; España. Universidad del País Vasco; España
Fil: Larrañeta, Eneko. The Queens University of Belfast; Irlanda
Fil: Donnelly, Ryan F.. The Queens University of Belfast; Irlanda
Fil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad del País Vasco; España
Fil: Paredes, Alejandro Javier. The Queens University of Belfast; Irlanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are attracting a great deal of interest in the biomedical space. Herein, we report the first example of adhesive Egels loading drug nanocrystals (Egel-NCs) for controlled delivery to mucosal tissues. These soft materials were prepared using gelatin, glycerine, a deep eutectic solvent (DES) based on choline hydrochloride and glycerol, and nanocrystallised curcumin, a model drug with potent antimicrobial and anti-inflammatory activities. We first explored the impact of the biopolymer concentration on the viscoelastic and mechanical properties of the networks. Thanks to the dynamic interactions between gelatin and the DES, the Egel showed excellent stretchability and elasticity (up to ≈160%), reversible gel-sol phase transition at mild temperature (≈50 ​°C), 3D-printing ability, and good adhesion to mucin protein (stickiness ≈40 ​kPa). In vitro release profiles demonstrated the ability of the NCs-based Egel to deliver curcumin for up to four weeks and deposit significantly higher drug amounts in excised porcine mucosa compared to the control cohort. All in all, this study opens new prospects in designing soft adhesive materials for long-acting drug delivery and paves the way to explore novel eutectic systems with multiple therapeutic applications.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/218520
Bianchi, María Beatrice; Zhang, Chunyang; Catlin, Elise; Sandri, Giuseppina; Calderón, Marcelo; et al.; Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues; Elsevier; Materials Today Bio; 17; 100471; 12-2022; 1-13
2590-0064
CONICET Digital
CONICET
url http://hdl.handle.net/11336/218520
identifier_str_mv Bianchi, María Beatrice; Zhang, Chunyang; Catlin, Elise; Sandri, Giuseppina; Calderón, Marcelo; et al.; Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues; Elsevier; Materials Today Bio; 17; 100471; 12-2022; 1-13
2590-0064
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mtbio.2022.100471
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2590006422002691
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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