The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway

Autores
Rayes, Diego Hernán; de Rosa, Maria Jose; Veuthey, Tania Vanesa; Florman, Jeremy; Grant, Jeff; Blanco, Maria Gabriela; Andersen, Natalia Denise; Alkema, Mark
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
An animal uses different survival strategies to cope with life-threatening situations. For instance, it can engage in a rapid and energy-demanding “fightor-flight” response when encountering a predator, or it can induce the gradual and long-lasting activation of highly conserved cytoprotective processes in response to environmental stressors such as hypoxia, heat, oxidative stress, or food shortage. In animals across the evolutionary spectrum the continued activation of the fight-or-flight response weakens the animal’s resistance to environmental challenges. In humans, for instance, the recurrent experience of stress in patients that suffer from post-traumatic stress disorder (PTSD) has been associated with decreased antioxidant capacity, accelerated aging and increased susceptibility to metabolic, cardiovascular and infectious diseases. However, the molecular and cellular mechanisms that regulate the trade-off between flight response and long-term stressors are poorly understood. Here we show that repeated induction of the C. elegans flight response shortens lifespan and inhibits conserved cytoprotective mechanisms. The flight response activates neurons that release tyramine, the invertebrate analog of adrenaline/noradrenaline. Tyramine stimulates the DAF-2/Insulin/IGF-1 pathway and precludes the induction of stress response genes by activating an adrenergic-like receptor in the intestine. In contrast, long-term environmental stressors, such as heat or oxidative stress, reduce tyramine release allowing the induction of cytoprotective genes. These findings demonstrate that a neural stress-hormone supplies a state-dependent neural switch between acute flight and long-term environmental stress responses and provides mechanistic insights into how the flight response impairs cellular defense systems and accelerates aging.
Fil: Rayes, Diego Hernán. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Grant, Jeff. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
22nd International C. elegans Conference
Los Angeles
Estados Unidos
Genetics Society of America
Materia
TYRAMINE
STRESS
LIFESPAN
PTSD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/192776
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathwayRayes, Diego Hernánde Rosa, Maria JoseVeuthey, Tania VanesaFlorman, JeremyGrant, JeffBlanco, Maria GabrielaAndersen, Natalia DeniseAlkema, MarkTYRAMINESTRESSLIFESPANPTSDhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1An animal uses different survival strategies to cope with life-threatening situations. For instance, it can engage in a rapid and energy-demanding “fightor-flight” response when encountering a predator, or it can induce the gradual and long-lasting activation of highly conserved cytoprotective processes in response to environmental stressors such as hypoxia, heat, oxidative stress, or food shortage. In animals across the evolutionary spectrum the continued activation of the fight-or-flight response weakens the animal’s resistance to environmental challenges. In humans, for instance, the recurrent experience of stress in patients that suffer from post-traumatic stress disorder (PTSD) has been associated with decreased antioxidant capacity, accelerated aging and increased susceptibility to metabolic, cardiovascular and infectious diseases. However, the molecular and cellular mechanisms that regulate the trade-off between flight response and long-term stressors are poorly understood. Here we show that repeated induction of the C. elegans flight response shortens lifespan and inhibits conserved cytoprotective mechanisms. The flight response activates neurons that release tyramine, the invertebrate analog of adrenaline/noradrenaline. Tyramine stimulates the DAF-2/Insulin/IGF-1 pathway and precludes the induction of stress response genes by activating an adrenergic-like receptor in the intestine. In contrast, long-term environmental stressors, such as heat or oxidative stress, reduce tyramine release allowing the induction of cytoprotective genes. These findings demonstrate that a neural stress-hormone supplies a state-dependent neural switch between acute flight and long-term environmental stress responses and provides mechanistic insights into how the flight response impairs cellular defense systems and accelerates aging.Fil: Rayes, Diego Hernán. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados UnidosFil: Grant, Jeff. University Of Massachussets. Medical School. Department Of Neurobiology; Estados UnidosFil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos22nd International C. elegans ConferenceLos AngelesEstados UnidosGenetics Society of AmericaGenetics Society of America2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/192776The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway; 22nd International C. elegans Conference; Los Angeles; Estados Unidos; 2019; 27-28CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://zoology.ubc.ca/event/2019/06/22nd-international-c-elegans-conferenceInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:16:45Zoai:ri.conicet.gov.ar:11336/192776instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:16:45.906CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway
title The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway
spellingShingle The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway
Rayes, Diego Hernán
TYRAMINE
STRESS
LIFESPAN
PTSD
title_short The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway
title_full The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway
title_fullStr The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway
title_full_unstemmed The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway
title_sort The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway
dc.creator.none.fl_str_mv Rayes, Diego Hernán
de Rosa, Maria Jose
Veuthey, Tania Vanesa
Florman, Jeremy
Grant, Jeff
Blanco, Maria Gabriela
Andersen, Natalia Denise
Alkema, Mark
author Rayes, Diego Hernán
author_facet Rayes, Diego Hernán
de Rosa, Maria Jose
Veuthey, Tania Vanesa
Florman, Jeremy
Grant, Jeff
Blanco, Maria Gabriela
Andersen, Natalia Denise
Alkema, Mark
author_role author
author2 de Rosa, Maria Jose
Veuthey, Tania Vanesa
Florman, Jeremy
Grant, Jeff
Blanco, Maria Gabriela
Andersen, Natalia Denise
Alkema, Mark
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TYRAMINE
STRESS
LIFESPAN
PTSD
topic TYRAMINE
STRESS
LIFESPAN
PTSD
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv An animal uses different survival strategies to cope with life-threatening situations. For instance, it can engage in a rapid and energy-demanding “fightor-flight” response when encountering a predator, or it can induce the gradual and long-lasting activation of highly conserved cytoprotective processes in response to environmental stressors such as hypoxia, heat, oxidative stress, or food shortage. In animals across the evolutionary spectrum the continued activation of the fight-or-flight response weakens the animal’s resistance to environmental challenges. In humans, for instance, the recurrent experience of stress in patients that suffer from post-traumatic stress disorder (PTSD) has been associated with decreased antioxidant capacity, accelerated aging and increased susceptibility to metabolic, cardiovascular and infectious diseases. However, the molecular and cellular mechanisms that regulate the trade-off between flight response and long-term stressors are poorly understood. Here we show that repeated induction of the C. elegans flight response shortens lifespan and inhibits conserved cytoprotective mechanisms. The flight response activates neurons that release tyramine, the invertebrate analog of adrenaline/noradrenaline. Tyramine stimulates the DAF-2/Insulin/IGF-1 pathway and precludes the induction of stress response genes by activating an adrenergic-like receptor in the intestine. In contrast, long-term environmental stressors, such as heat or oxidative stress, reduce tyramine release allowing the induction of cytoprotective genes. These findings demonstrate that a neural stress-hormone supplies a state-dependent neural switch between acute flight and long-term environmental stress responses and provides mechanistic insights into how the flight response impairs cellular defense systems and accelerates aging.
Fil: Rayes, Diego Hernán. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Grant, Jeff. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
22nd International C. elegans Conference
Los Angeles
Estados Unidos
Genetics Society of America
description An animal uses different survival strategies to cope with life-threatening situations. For instance, it can engage in a rapid and energy-demanding “fightor-flight” response when encountering a predator, or it can induce the gradual and long-lasting activation of highly conserved cytoprotective processes in response to environmental stressors such as hypoxia, heat, oxidative stress, or food shortage. In animals across the evolutionary spectrum the continued activation of the fight-or-flight response weakens the animal’s resistance to environmental challenges. In humans, for instance, the recurrent experience of stress in patients that suffer from post-traumatic stress disorder (PTSD) has been associated with decreased antioxidant capacity, accelerated aging and increased susceptibility to metabolic, cardiovascular and infectious diseases. However, the molecular and cellular mechanisms that regulate the trade-off between flight response and long-term stressors are poorly understood. Here we show that repeated induction of the C. elegans flight response shortens lifespan and inhibits conserved cytoprotective mechanisms. The flight response activates neurons that release tyramine, the invertebrate analog of adrenaline/noradrenaline. Tyramine stimulates the DAF-2/Insulin/IGF-1 pathway and precludes the induction of stress response genes by activating an adrenergic-like receptor in the intestine. In contrast, long-term environmental stressors, such as heat or oxidative stress, reduce tyramine release allowing the induction of cytoprotective genes. These findings demonstrate that a neural stress-hormone supplies a state-dependent neural switch between acute flight and long-term environmental stress responses and provides mechanistic insights into how the flight response impairs cellular defense systems and accelerates aging.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/192776
The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway; 22nd International C. elegans Conference; Los Angeles; Estados Unidos; 2019; 27-28
CONICET Digital
CONICET
url http://hdl.handle.net/11336/192776
identifier_str_mv The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway; 22nd International C. elegans Conference; Los Angeles; Estados Unidos; 2019; 27-28
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://zoology.ubc.ca/event/2019/06/22nd-international-c-elegans-conference
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Genetics Society of America
publisher.none.fl_str_mv Genetics Society of America
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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