New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger

Autores
Malanga, Gabriela Fabiana; Aguiar, María Belén; Martinez, Hugo D.; Puntarulo, Susana Ángela
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.
Fil: Malanga, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina
Fil: Aguiar, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina
Fil: Martinez, Hugo D.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina
Fil: Puntarulo, Susana Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ANTIOXIDANT
ASCORBYL RADICAL
DIMETHYLAMINOETHANOL (DMAE)
HYDROXYL RADICAL
LIPID RADICALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194780
Acceder
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network_name_str CONICET Digital (CONICET)
spelling New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical ScavengerMalanga, Gabriela FabianaAguiar, María BelénMartinez, Hugo D.Puntarulo, Susana ÁngelaANTIOXIDANTASCORBYL RADICALDIMETHYLAMINOETHANOL (DMAE)HYDROXYL RADICALLIPID RADICALShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.Fil: Malanga, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; ArgentinaFil: Aguiar, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; ArgentinaFil: Martinez, Hugo D.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; ArgentinaFil: Puntarulo, Susana Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBentham Science Publishers2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194780Malanga, Gabriela Fabiana; Aguiar, María Belén; Martinez, Hugo D.; Puntarulo, Susana Ángela; New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger; Bentham Science Publishers; Drug Metabolism Letters; 6; 1; 1-2012; 54-591872-3128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/article/42435info:eu-repo/semantics/altIdentifier/doi/10.2174/187231212800229282info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:40Zoai:ri.conicet.gov.ar:11336/194780instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:40.33CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
title New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
spellingShingle New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
Malanga, Gabriela Fabiana
ANTIOXIDANT
ASCORBYL RADICAL
DIMETHYLAMINOETHANOL (DMAE)
HYDROXYL RADICAL
LIPID RADICALS
title_short New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
title_full New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
title_fullStr New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
title_full_unstemmed New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
title_sort New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
dc.creator.none.fl_str_mv Malanga, Gabriela Fabiana
Aguiar, María Belén
Martinez, Hugo D.
Puntarulo, Susana Ángela
author Malanga, Gabriela Fabiana
author_facet Malanga, Gabriela Fabiana
Aguiar, María Belén
Martinez, Hugo D.
Puntarulo, Susana Ángela
author_role author
author2 Aguiar, María Belén
Martinez, Hugo D.
Puntarulo, Susana Ángela
author2_role author
author
author
dc.subject.none.fl_str_mv ANTIOXIDANT
ASCORBYL RADICAL
DIMETHYLAMINOETHANOL (DMAE)
HYDROXYL RADICAL
LIPID RADICALS
topic ANTIOXIDANT
ASCORBYL RADICAL
DIMETHYLAMINOETHANOL (DMAE)
HYDROXYL RADICAL
LIPID RADICALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.
Fil: Malanga, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina
Fil: Aguiar, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina
Fil: Martinez, Hugo D.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina
Fil: Puntarulo, Susana Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194780
Malanga, Gabriela Fabiana; Aguiar, María Belén; Martinez, Hugo D.; Puntarulo, Susana Ángela; New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger; Bentham Science Publishers; Drug Metabolism Letters; 6; 1; 1-2012; 54-59
1872-3128
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194780
identifier_str_mv Malanga, Gabriela Fabiana; Aguiar, María Belén; Martinez, Hugo D.; Puntarulo, Susana Ángela; New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger; Bentham Science Publishers; Drug Metabolism Letters; 6; 1; 1-2012; 54-59
1872-3128
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/article/42435
info:eu-repo/semantics/altIdentifier/doi/10.2174/187231212800229282
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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