Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease

Autores
Terroba Chambi, Cinthia Jennifer; Rossi, Malco Damián; Bril, Andrea; Vernetti, Patricio Millar; Cerquetti, Daniel; Cammarota, Angel; Merello, Marcelo Jorge
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The diagnosis of Parkinson's disease (PD) can be challenging early in the diseasecourse, when motor features are subtle. The objective of this study was to explore the diagnostic value ofcombining acute levodopa challenge and olfactory testing to predict PD.Methods: Data from 210 patients with a recent onset of parkinsonism who had at least 2 years of follow-upand underwent acute levodopa challenge for the clinical prediction of long-term dopaminergic response andhad olfactory testing with Sniffin? Sticks Test were evaluated. Single and combined diagnostic measures wereanalyzed.Results: After 2 years of follow-up, a PD diagnosis was confirmed in 157 patients who fulfilled United KingdomParkinson?s Disease Society Brain Bank criteria and was ruled out in 53. Sensitivity and specificity of acutelevodopa challenge to predict PD diagnosis were 0.71 and 0.94, respectively. Sensitivity and specificity ofolfactory tests were calculated according to the total olfactory score for hyposmia (0.61 and 0.77respectively), the hyposmia identification subscore (0.63 and 0.74, respectively), and the anosmia score (0.40and 0.85, respectively). The best combination identified was response to acute levodopa challenge togetherwith hyposmia according to the total olfactory score (sensitivity, 0.90; specificity, 0.74; positive predictivevalue, 0.91; negative predictive value, 0.72; accuracy, 0.86).Conclusion: The combination of response to acute levodopa challenge with hyposmia according to the totalolfactory score improved sensitivity for the early diagnosis of PD.
Fil: Terroba Chambi, Cinthia Jennifer. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rossi, Malco Damián. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bril, Andrea. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Vernetti, Patricio Millar. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Cerquetti, Daniel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Cammarota, Angel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Merello, Marcelo Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Olfaction
Parkinson
Levodopa Challenge
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/72839
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/72839
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's DiseaseTerroba Chambi, Cinthia JenniferRossi, Malco DamiánBril, AndreaVernetti, Patricio MillarCerquetti, DanielCammarota, AngelMerello, Marcelo JorgeOlfactionParkinsonLevodopa Challengehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: The diagnosis of Parkinson's disease (PD) can be challenging early in the diseasecourse, when motor features are subtle. The objective of this study was to explore the diagnostic value ofcombining acute levodopa challenge and olfactory testing to predict PD.Methods: Data from 210 patients with a recent onset of parkinsonism who had at least 2 years of follow-upand underwent acute levodopa challenge for the clinical prediction of long-term dopaminergic response andhad olfactory testing with Sniffin? Sticks Test were evaluated. Single and combined diagnostic measures wereanalyzed.Results: After 2 years of follow-up, a PD diagnosis was confirmed in 157 patients who fulfilled United KingdomParkinson?s Disease Society Brain Bank criteria and was ruled out in 53. Sensitivity and specificity of acutelevodopa challenge to predict PD diagnosis were 0.71 and 0.94, respectively. Sensitivity and specificity ofolfactory tests were calculated according to the total olfactory score for hyposmia (0.61 and 0.77respectively), the hyposmia identification subscore (0.63 and 0.74, respectively), and the anosmia score (0.40and 0.85, respectively). The best combination identified was response to acute levodopa challenge togetherwith hyposmia according to the total olfactory score (sensitivity, 0.90; specificity, 0.74; positive predictivevalue, 0.91; negative predictive value, 0.72; accuracy, 0.86).Conclusion: The combination of response to acute levodopa challenge with hyposmia according to the totalolfactory score improved sensitivity for the early diagnosis of PD.Fil: Terroba Chambi, Cinthia Jennifer. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rossi, Malco Damián. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bril, Andrea. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Vernetti, Patricio Millar. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Cerquetti, Daniel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Cammarota, Angel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Merello, Marcelo Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/72839Terroba Chambi, Cinthia Jennifer; Rossi, Malco Damián; Bril, Andrea; Vernetti, Patricio Millar; Cerquetti, Daniel; et al.; Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease; Wiley; Movement Disorders Clinical Practice; 4; 6; 11-2017; 824-8282330-1619CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/mdc3.12517info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/mdc3.12517info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:33:07Zoai:ri.conicet.gov.ar:11336/72839instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:33:07.622CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
title Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
spellingShingle Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
Terroba Chambi, Cinthia Jennifer
Olfaction
Parkinson
Levodopa Challenge
title_short Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
title_full Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
title_fullStr Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
title_full_unstemmed Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
title_sort Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
dc.creator.none.fl_str_mv Terroba Chambi, Cinthia Jennifer
Rossi, Malco Damián
Bril, Andrea
Vernetti, Patricio Millar
Cerquetti, Daniel
Cammarota, Angel
Merello, Marcelo Jorge
author Terroba Chambi, Cinthia Jennifer
author_facet Terroba Chambi, Cinthia Jennifer
Rossi, Malco Damián
Bril, Andrea
Vernetti, Patricio Millar
Cerquetti, Daniel
Cammarota, Angel
Merello, Marcelo Jorge
author_role author
author2 Rossi, Malco Damián
Bril, Andrea
Vernetti, Patricio Millar
Cerquetti, Daniel
Cammarota, Angel
Merello, Marcelo Jorge
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Olfaction
Parkinson
Levodopa Challenge
topic Olfaction
Parkinson
Levodopa Challenge
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The diagnosis of Parkinson's disease (PD) can be challenging early in the diseasecourse, when motor features are subtle. The objective of this study was to explore the diagnostic value ofcombining acute levodopa challenge and olfactory testing to predict PD.Methods: Data from 210 patients with a recent onset of parkinsonism who had at least 2 years of follow-upand underwent acute levodopa challenge for the clinical prediction of long-term dopaminergic response andhad olfactory testing with Sniffin? Sticks Test were evaluated. Single and combined diagnostic measures wereanalyzed.Results: After 2 years of follow-up, a PD diagnosis was confirmed in 157 patients who fulfilled United KingdomParkinson?s Disease Society Brain Bank criteria and was ruled out in 53. Sensitivity and specificity of acutelevodopa challenge to predict PD diagnosis were 0.71 and 0.94, respectively. Sensitivity and specificity ofolfactory tests were calculated according to the total olfactory score for hyposmia (0.61 and 0.77respectively), the hyposmia identification subscore (0.63 and 0.74, respectively), and the anosmia score (0.40and 0.85, respectively). The best combination identified was response to acute levodopa challenge togetherwith hyposmia according to the total olfactory score (sensitivity, 0.90; specificity, 0.74; positive predictivevalue, 0.91; negative predictive value, 0.72; accuracy, 0.86).Conclusion: The combination of response to acute levodopa challenge with hyposmia according to the totalolfactory score improved sensitivity for the early diagnosis of PD.
Fil: Terroba Chambi, Cinthia Jennifer. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rossi, Malco Damián. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bril, Andrea. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Vernetti, Patricio Millar. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Cerquetti, Daniel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Cammarota, Angel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Merello, Marcelo Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: The diagnosis of Parkinson's disease (PD) can be challenging early in the diseasecourse, when motor features are subtle. The objective of this study was to explore the diagnostic value ofcombining acute levodopa challenge and olfactory testing to predict PD.Methods: Data from 210 patients with a recent onset of parkinsonism who had at least 2 years of follow-upand underwent acute levodopa challenge for the clinical prediction of long-term dopaminergic response andhad olfactory testing with Sniffin? Sticks Test were evaluated. Single and combined diagnostic measures wereanalyzed.Results: After 2 years of follow-up, a PD diagnosis was confirmed in 157 patients who fulfilled United KingdomParkinson?s Disease Society Brain Bank criteria and was ruled out in 53. Sensitivity and specificity of acutelevodopa challenge to predict PD diagnosis were 0.71 and 0.94, respectively. Sensitivity and specificity ofolfactory tests were calculated according to the total olfactory score for hyposmia (0.61 and 0.77respectively), the hyposmia identification subscore (0.63 and 0.74, respectively), and the anosmia score (0.40and 0.85, respectively). The best combination identified was response to acute levodopa challenge togetherwith hyposmia according to the total olfactory score (sensitivity, 0.90; specificity, 0.74; positive predictivevalue, 0.91; negative predictive value, 0.72; accuracy, 0.86).Conclusion: The combination of response to acute levodopa challenge with hyposmia according to the totalolfactory score improved sensitivity for the early diagnosis of PD.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/72839
Terroba Chambi, Cinthia Jennifer; Rossi, Malco Damián; Bril, Andrea; Vernetti, Patricio Millar; Cerquetti, Daniel; et al.; Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease; Wiley; Movement Disorders Clinical Practice; 4; 6; 11-2017; 824-828
2330-1619
CONICET Digital
CONICET
url http://hdl.handle.net/11336/72839
identifier_str_mv Terroba Chambi, Cinthia Jennifer; Rossi, Malco Damián; Bril, Andrea; Vernetti, Patricio Millar; Cerquetti, Daniel; et al.; Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease; Wiley; Movement Disorders Clinical Practice; 4; 6; 11-2017; 824-828
2330-1619
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/mdc3.12517
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/mdc3.12517
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.976206

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