Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection

Autores
Di Lello, Federico Alejandro; Mira, José Antonio; Neukam, Karin; Parra Sánchez, Manuel; Guelfo, Javier R.; Cifuentes, Celia; Macias, Juan; Palomares, José Carlos; Gomez Mateos, Jesús; Pineda, Juan Antonio; Real, Luis M.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to analyze the impact of core variations on sustained virological response (SVR) to pegylated interferon plus ribavirin (PEG-IFN/RBV) and its association with predictive factors of response in Caucasian patients infected with genotype 1 hepatitis C virus (HCV-1). Full-length core sequences were analyzed in 100 Caucasian HCV-1-infected patients who received therapy with PEG-IFN/RBV. The associations between variations in the core protein and SVR, as well as with predictors of SVR, were analyzed. Variations at core 62, 70 and 110 were selected as candidates. There were almost no variations at these positions among patients harboring HCV-1a. However, they were identified in 10 (30.3 %), 21 (63.6 %) and 13 (39.4 %) subjects with HCV-1b, respectively. Among the HCV-1b patients, 39.1 % individuals carrying core R62 and 70 % subjects with core R62G showed SVR (p = 0.141), and 66.7 % of HCV-1b patients harboring core R70 and 38.1 % with core R70Q achieved SVR (p = 0.157), whereas the rate of SVR was 70 % for individuals with core T110 and 15.4 % for those with core T110N (p = 0.004). No statistical interaction between core variations and IL28B genotype was observed. Patients with R70 showed higher median (interquartile range) baseline plasma levels of low-density-lipoprotein cholesterol (LDL-C) than those with R70Q (96 [86-118] mg/dL vs. 76 [54-88] mg/dL, p = 0.014). We concluded that a substitution at core 110 is associated with a lower rate of SVR in Caucasian HCV-1b-infected patients receiving PEG-IFN/RBV. Furthermore, the variation at the core 70 position is related to plasma levels of LDL-C in these patients.
Fil: Di Lello, Federico Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario de Valme; España
Fil: Mira, José Antonio. Hospital Universitario de Valme; España
Fil: Neukam, Karin. Hospital Universitario de Valme; España
Fil: Parra Sánchez, Manuel. Hospital Universitario de Valme; España
Fil: Guelfo, Javier R.. Hospital Universitario de Valme; España
Fil: Cifuentes, Celia. Hospital Universitario de Valme; España
Fil: Macias, Juan. Hospital Universitario de Valme; España
Fil: Palomares, José Carlos. Hospital Universitario de Valme; España
Fil: Gomez Mateos, Jesús. Hospital Universitario de Valme; España
Fil: Pineda, Juan Antonio. Hospital Universitario de Valme; España
Fil: Real, Luis M.. Hospital Universitario de Valme; España
Materia
Hepatitis C Virus
Mutation
Treatment
Core
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15808
Acceder
id CONICETDig_f8d649741a99a2f8de4b9c8003d37433
oai_identifier_str oai:ri.conicet.gov.ar:11336/15808
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infectionDi Lello, Federico AlejandroMira, José AntonioNeukam, KarinParra Sánchez, ManuelGuelfo, Javier R.Cifuentes, CeliaMacias, JuanPalomares, José CarlosGomez Mateos, JesúsPineda, Juan AntonioReal, Luis M.Hepatitis C VirusMutationTreatmentCorehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The aim of this study was to analyze the impact of core variations on sustained virological response (SVR) to pegylated interferon plus ribavirin (PEG-IFN/RBV) and its association with predictive factors of response in Caucasian patients infected with genotype 1 hepatitis C virus (HCV-1). Full-length core sequences were analyzed in 100 Caucasian HCV-1-infected patients who received therapy with PEG-IFN/RBV. The associations between variations in the core protein and SVR, as well as with predictors of SVR, were analyzed. Variations at core 62, 70 and 110 were selected as candidates. There were almost no variations at these positions among patients harboring HCV-1a. However, they were identified in 10 (30.3 %), 21 (63.6 %) and 13 (39.4 %) subjects with HCV-1b, respectively. Among the HCV-1b patients, 39.1 % individuals carrying core R62 and 70 % subjects with core R62G showed SVR (p = 0.141), and 66.7 % of HCV-1b patients harboring core R70 and 38.1 % with core R70Q achieved SVR (p = 0.157), whereas the rate of SVR was 70 % for individuals with core T110 and 15.4 % for those with core T110N (p = 0.004). No statistical interaction between core variations and IL28B genotype was observed. Patients with R70 showed higher median (interquartile range) baseline plasma levels of low-density-lipoprotein cholesterol (LDL-C) than those with R70Q (96 [86-118] mg/dL vs. 76 [54-88] mg/dL, p = 0.014). We concluded that a substitution at core 110 is associated with a lower rate of SVR in Caucasian HCV-1b-infected patients receiving PEG-IFN/RBV. Furthermore, the variation at the core 70 position is related to plasma levels of LDL-C in these patients.Fil: Di Lello, Federico Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario de Valme; EspañaFil: Mira, José Antonio. Hospital Universitario de Valme; EspañaFil: Neukam, Karin. Hospital Universitario de Valme; EspañaFil: Parra Sánchez, Manuel. Hospital Universitario de Valme; EspañaFil: Guelfo, Javier R.. Hospital Universitario de Valme; EspañaFil: Cifuentes, Celia. Hospital Universitario de Valme; EspañaFil: Macias, Juan. Hospital Universitario de Valme; EspañaFil: Palomares, José Carlos. Hospital Universitario de Valme; EspañaFil: Gomez Mateos, Jesús. Hospital Universitario de Valme; EspañaFil: Pineda, Juan Antonio. Hospital Universitario de Valme; EspañaFil: Real, Luis M.. Hospital Universitario de Valme; EspañaSpringer Wien2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15808Di Lello, Federico Alejandro; Mira, José Antonio; Neukam, Karin; Parra Sánchez, Manuel; Guelfo, Javier R.; et al.; Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection; Springer Wien; Archives of Virology; 159; 12; 12-2014; 3345-33510304-86081432-8798enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-014-2209-xinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-014-2209-xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:35Zoai:ri.conicet.gov.ar:11336/15808instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:36.016CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection
title Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection
spellingShingle Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection
Di Lello, Federico Alejandro
Hepatitis C Virus
Mutation
Treatment
Core
title_short Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection
title_full Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection
title_fullStr Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection
title_full_unstemmed Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection
title_sort Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection
dc.creator.none.fl_str_mv Di Lello, Federico Alejandro
Mira, José Antonio
Neukam, Karin
Parra Sánchez, Manuel
Guelfo, Javier R.
Cifuentes, Celia
Macias, Juan
Palomares, José Carlos
Gomez Mateos, Jesús
Pineda, Juan Antonio
Real, Luis M.
author Di Lello, Federico Alejandro
author_facet Di Lello, Federico Alejandro
Mira, José Antonio
Neukam, Karin
Parra Sánchez, Manuel
Guelfo, Javier R.
Cifuentes, Celia
Macias, Juan
Palomares, José Carlos
Gomez Mateos, Jesús
Pineda, Juan Antonio
Real, Luis M.
author_role author
author2 Mira, José Antonio
Neukam, Karin
Parra Sánchez, Manuel
Guelfo, Javier R.
Cifuentes, Celia
Macias, Juan
Palomares, José Carlos
Gomez Mateos, Jesús
Pineda, Juan Antonio
Real, Luis M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hepatitis C Virus
Mutation
Treatment
Core
topic Hepatitis C Virus
Mutation
Treatment
Core
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this study was to analyze the impact of core variations on sustained virological response (SVR) to pegylated interferon plus ribavirin (PEG-IFN/RBV) and its association with predictive factors of response in Caucasian patients infected with genotype 1 hepatitis C virus (HCV-1). Full-length core sequences were analyzed in 100 Caucasian HCV-1-infected patients who received therapy with PEG-IFN/RBV. The associations between variations in the core protein and SVR, as well as with predictors of SVR, were analyzed. Variations at core 62, 70 and 110 were selected as candidates. There were almost no variations at these positions among patients harboring HCV-1a. However, they were identified in 10 (30.3 %), 21 (63.6 %) and 13 (39.4 %) subjects with HCV-1b, respectively. Among the HCV-1b patients, 39.1 % individuals carrying core R62 and 70 % subjects with core R62G showed SVR (p = 0.141), and 66.7 % of HCV-1b patients harboring core R70 and 38.1 % with core R70Q achieved SVR (p = 0.157), whereas the rate of SVR was 70 % for individuals with core T110 and 15.4 % for those with core T110N (p = 0.004). No statistical interaction between core variations and IL28B genotype was observed. Patients with R70 showed higher median (interquartile range) baseline plasma levels of low-density-lipoprotein cholesterol (LDL-C) than those with R70Q (96 [86-118] mg/dL vs. 76 [54-88] mg/dL, p = 0.014). We concluded that a substitution at core 110 is associated with a lower rate of SVR in Caucasian HCV-1b-infected patients receiving PEG-IFN/RBV. Furthermore, the variation at the core 70 position is related to plasma levels of LDL-C in these patients.
Fil: Di Lello, Federico Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario de Valme; España
Fil: Mira, José Antonio. Hospital Universitario de Valme; España
Fil: Neukam, Karin. Hospital Universitario de Valme; España
Fil: Parra Sánchez, Manuel. Hospital Universitario de Valme; España
Fil: Guelfo, Javier R.. Hospital Universitario de Valme; España
Fil: Cifuentes, Celia. Hospital Universitario de Valme; España
Fil: Macias, Juan. Hospital Universitario de Valme; España
Fil: Palomares, José Carlos. Hospital Universitario de Valme; España
Fil: Gomez Mateos, Jesús. Hospital Universitario de Valme; España
Fil: Pineda, Juan Antonio. Hospital Universitario de Valme; España
Fil: Real, Luis M.. Hospital Universitario de Valme; España
description The aim of this study was to analyze the impact of core variations on sustained virological response (SVR) to pegylated interferon plus ribavirin (PEG-IFN/RBV) and its association with predictive factors of response in Caucasian patients infected with genotype 1 hepatitis C virus (HCV-1). Full-length core sequences were analyzed in 100 Caucasian HCV-1-infected patients who received therapy with PEG-IFN/RBV. The associations between variations in the core protein and SVR, as well as with predictors of SVR, were analyzed. Variations at core 62, 70 and 110 were selected as candidates. There were almost no variations at these positions among patients harboring HCV-1a. However, they were identified in 10 (30.3 %), 21 (63.6 %) and 13 (39.4 %) subjects with HCV-1b, respectively. Among the HCV-1b patients, 39.1 % individuals carrying core R62 and 70 % subjects with core R62G showed SVR (p = 0.141), and 66.7 % of HCV-1b patients harboring core R70 and 38.1 % with core R70Q achieved SVR (p = 0.157), whereas the rate of SVR was 70 % for individuals with core T110 and 15.4 % for those with core T110N (p = 0.004). No statistical interaction between core variations and IL28B genotype was observed. Patients with R70 showed higher median (interquartile range) baseline plasma levels of low-density-lipoprotein cholesterol (LDL-C) than those with R70Q (96 [86-118] mg/dL vs. 76 [54-88] mg/dL, p = 0.014). We concluded that a substitution at core 110 is associated with a lower rate of SVR in Caucasian HCV-1b-infected patients receiving PEG-IFN/RBV. Furthermore, the variation at the core 70 position is related to plasma levels of LDL-C in these patients.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15808
Di Lello, Federico Alejandro; Mira, José Antonio; Neukam, Karin; Parra Sánchez, Manuel; Guelfo, Javier R.; et al.; Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection; Springer Wien; Archives of Virology; 159; 12; 12-2014; 3345-3351
0304-8608
1432-8798
url http://hdl.handle.net/11336/15808
identifier_str_mv Di Lello, Federico Alejandro; Mira, José Antonio; Neukam, Karin; Parra Sánchez, Manuel; Guelfo, Javier R.; et al.; Core amino acid variation at position 110 is associated with sustained virological response in Caucasian patients with chronic hepatitis C virus 1b infection; Springer Wien; Archives of Virology; 159; 12; 12-2014; 3345-3351
0304-8608
1432-8798
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-014-2209-x
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-014-2209-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Wien
publisher.none.fl_str_mv Springer Wien
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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