Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances

Autores
Arevalo, María Angeles; Ruiz Palmero, Isabel; Scerbo, María Julia; Acaz Fonseca, Estefanía; Cambiasso, Maria Julia; Garcia Segura, Luis Miguel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review analyzes the signaling mechanisms activated by estradiol to regulate neuritogenesis in several neuronal populations. Estradiol regulates axogenesis by the activation of the mitogen activated protein kinase (MAPK) cascade through estrogen receptor á located in the plasma membrane. In addition, estradiol regulates MAPK signaling via the activation of protein kinase C and by increasing the expression of brain derived neurotrophic factor and tyrosine kinase receptor B. Estradiol also interacts with the signaling of insulin-like growth factor-I receptor through estrogen receptor á, modulating the phosphoinositide-3 kinase signaling pathway, which contributes to the stabilization of microtubules. Finally, estradiol modulates dendritogenesis by the inhibition of Notch signaling, by a mechanism that, at least in hippocampal neurons, is mediated by G-protein coupled receptor 30. This article is part of a Special Issue entitled ‘Neurosteroids’.
Fil: Arevalo, María Angeles. Instituto Cajal; España
Fil: Ruiz Palmero, Isabel. Instituto Cajal; España
Fil: Scerbo, María Julia. Instituto de Investigacion Medica Mercedes y Martin Ferreyra.; Argentina
Fil: Acaz Fonseca, Estefanía. Instituto Cajal; España
Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Garcia Segura, Luis Miguel. Instituto Cajal; España
Materia
Brain derived neurotrophic factor
Estrogen receptors
G-protein-coupled-receptor 30
Insulin-like growth factor-I
Mitogen activated protein kinase
Neurogenin 3
Phosphoinositide-3 kinase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271745
Acceder
id CONICETDig_f8cffd897ab0ff3d502816a12bbbf6a0
oai_identifier_str oai:ri.conicet.gov.ar:11336/271745
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advancesArevalo, María AngelesRuiz Palmero, IsabelScerbo, María JuliaAcaz Fonseca, EstefaníaCambiasso, Maria JuliaGarcia Segura, Luis MiguelBrain derived neurotrophic factorEstrogen receptorsG-protein-coupled-receptor 30Insulin-like growth factor-IMitogen activated protein kinaseNeurogenin 3Phosphoinositide-3 kinasehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This review analyzes the signaling mechanisms activated by estradiol to regulate neuritogenesis in several neuronal populations. Estradiol regulates axogenesis by the activation of the mitogen activated protein kinase (MAPK) cascade through estrogen receptor á located in the plasma membrane. In addition, estradiol regulates MAPK signaling via the activation of protein kinase C and by increasing the expression of brain derived neurotrophic factor and tyrosine kinase receptor B. Estradiol also interacts with the signaling of insulin-like growth factor-I receptor through estrogen receptor á, modulating the phosphoinositide-3 kinase signaling pathway, which contributes to the stabilization of microtubules. Finally, estradiol modulates dendritogenesis by the inhibition of Notch signaling, by a mechanism that, at least in hippocampal neurons, is mediated by G-protein coupled receptor 30. This article is part of a Special Issue entitled ‘Neurosteroids’.Fil: Arevalo, María Angeles. Instituto Cajal; EspañaFil: Ruiz Palmero, Isabel. Instituto Cajal; EspañaFil: Scerbo, María Julia. Instituto de Investigacion Medica Mercedes y Martin Ferreyra.; ArgentinaFil: Acaz Fonseca, Estefanía. Instituto Cajal; EspañaFil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Garcia Segura, Luis Miguel. Instituto Cajal; EspañaPergamon-Elsevier Science Ltd2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271745Arevalo, María Angeles; Ruiz Palmero, Isabel; Scerbo, María Julia; Acaz Fonseca, Estefanía; Cambiasso, Maria Julia; et al.; Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances; Pergamon-Elsevier Science Ltd; Journal of Steroid Biochemistry and Molecular Biology; 131; 1-2; 8-2012; 52-560960-0760CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960076011001932info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2011.09.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:37Zoai:ri.conicet.gov.ar:11336/271745instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:37.91CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
title Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
spellingShingle Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
Arevalo, María Angeles
Brain derived neurotrophic factor
Estrogen receptors
G-protein-coupled-receptor 30
Insulin-like growth factor-I
Mitogen activated protein kinase
Neurogenin 3
Phosphoinositide-3 kinase
title_short Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
title_full Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
title_fullStr Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
title_full_unstemmed Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
title_sort Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances
dc.creator.none.fl_str_mv Arevalo, María Angeles
Ruiz Palmero, Isabel
Scerbo, María Julia
Acaz Fonseca, Estefanía
Cambiasso, Maria Julia
Garcia Segura, Luis Miguel
author Arevalo, María Angeles
author_facet Arevalo, María Angeles
Ruiz Palmero, Isabel
Scerbo, María Julia
Acaz Fonseca, Estefanía
Cambiasso, Maria Julia
Garcia Segura, Luis Miguel
author_role author
author2 Ruiz Palmero, Isabel
Scerbo, María Julia
Acaz Fonseca, Estefanía
Cambiasso, Maria Julia
Garcia Segura, Luis Miguel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Brain derived neurotrophic factor
Estrogen receptors
G-protein-coupled-receptor 30
Insulin-like growth factor-I
Mitogen activated protein kinase
Neurogenin 3
Phosphoinositide-3 kinase
topic Brain derived neurotrophic factor
Estrogen receptors
G-protein-coupled-receptor 30
Insulin-like growth factor-I
Mitogen activated protein kinase
Neurogenin 3
Phosphoinositide-3 kinase
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This review analyzes the signaling mechanisms activated by estradiol to regulate neuritogenesis in several neuronal populations. Estradiol regulates axogenesis by the activation of the mitogen activated protein kinase (MAPK) cascade through estrogen receptor á located in the plasma membrane. In addition, estradiol regulates MAPK signaling via the activation of protein kinase C and by increasing the expression of brain derived neurotrophic factor and tyrosine kinase receptor B. Estradiol also interacts with the signaling of insulin-like growth factor-I receptor through estrogen receptor á, modulating the phosphoinositide-3 kinase signaling pathway, which contributes to the stabilization of microtubules. Finally, estradiol modulates dendritogenesis by the inhibition of Notch signaling, by a mechanism that, at least in hippocampal neurons, is mediated by G-protein coupled receptor 30. This article is part of a Special Issue entitled ‘Neurosteroids’.
Fil: Arevalo, María Angeles. Instituto Cajal; España
Fil: Ruiz Palmero, Isabel. Instituto Cajal; España
Fil: Scerbo, María Julia. Instituto de Investigacion Medica Mercedes y Martin Ferreyra.; Argentina
Fil: Acaz Fonseca, Estefanía. Instituto Cajal; España
Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Garcia Segura, Luis Miguel. Instituto Cajal; España
description This review analyzes the signaling mechanisms activated by estradiol to regulate neuritogenesis in several neuronal populations. Estradiol regulates axogenesis by the activation of the mitogen activated protein kinase (MAPK) cascade through estrogen receptor á located in the plasma membrane. In addition, estradiol regulates MAPK signaling via the activation of protein kinase C and by increasing the expression of brain derived neurotrophic factor and tyrosine kinase receptor B. Estradiol also interacts with the signaling of insulin-like growth factor-I receptor through estrogen receptor á, modulating the phosphoinositide-3 kinase signaling pathway, which contributes to the stabilization of microtubules. Finally, estradiol modulates dendritogenesis by the inhibition of Notch signaling, by a mechanism that, at least in hippocampal neurons, is mediated by G-protein coupled receptor 30. This article is part of a Special Issue entitled ‘Neurosteroids’.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271745
Arevalo, María Angeles; Ruiz Palmero, Isabel; Scerbo, María Julia; Acaz Fonseca, Estefanía; Cambiasso, Maria Julia; et al.; Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances; Pergamon-Elsevier Science Ltd; Journal of Steroid Biochemistry and Molecular Biology; 131; 1-2; 8-2012; 52-56
0960-0760
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271745
identifier_str_mv Arevalo, María Angeles; Ruiz Palmero, Isabel; Scerbo, María Julia; Acaz Fonseca, Estefanía; Cambiasso, Maria Julia; et al.; Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances; Pergamon-Elsevier Science Ltd; Journal of Steroid Biochemistry and Molecular Biology; 131; 1-2; 8-2012; 52-56
0960-0760
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960076011001932
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2011.09.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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