Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis

Autores
Brites, Fernando Daniel; Fernández, Karina M.; Verona, Julián; Malusardi, María C.; Ischoff, Paula; Beresan, Hugo; Elbert, Alicia; Wikinski, Regina L.
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Diabetic patients are at high risk of cardiovascular disease and the risk isamplified in the presence of nephropathy, which may be partially attributed tomodifications in lipoproteins. Moreover, lipoprotein profile may be affected byincipient nephropathy, glomerulopathy, and mild or severe renal failure. The aim of our study was to evaluate whether chronic renal failure (CRF) changeslipoprotein profile and apo A-I urinary excretion in diabetic subjects withglomerulopathy in comparison with non-diabetic subjects with glomerulopathy andCRF. Diabetic (n=25) and non-diabetic (n=10) patients with glomerulopathy and CRFshowed significantly higher LDL-cholesterol, non-HDL-cholesterol andHDL-triglyceride levels than diabetic individuals without CRF (n=10).Arylesterase and paraoxonase activities did not show any difference betweengroups. Apo A-I could not be detected in urine samples from diabetic patientswithout CRF. All diabetic subjects with glomerulopathy and CRF who presentedproteinuria above 6.5 g/24 h showed detectable urinary apo A-I (range=13.1-61.0mg/24 h). Similarly, all non-diabetic patients with glomerulopathy and CRF whohad proteinuria above 8.0 g/24 h also evidenced detectable apo A-I in urine(range=25.6-557.3 mg/24 h). Urinary apo A-I showed positive and significantcorrelations with urea (r=0.73, p<0.05) and proteinuria (r=0.97, p<0.0001), and anegative correlation with albumin plasma levels (r=-0.68, p<0.05). In conclusion,the presence of CRF in diabetic patients was associated with a more atherogeniclipoprotein profile.
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández, Karina M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Verona, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Malusardi, María C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Ischoff, Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Beresan, Hugo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Elbert, Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Wikinski, Regina L.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Materia
Chronic renal failure
diabetes
lipoproteins
atherosclerosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241966
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/241966
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosisBrites, Fernando DanielFernández, Karina M.Verona, JuliánMalusardi, María C.Ischoff, PaulaBeresan, HugoElbert, AliciaWikinski, Regina L.Chronic renal failurediabeteslipoproteinsatherosclerosishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Diabetic patients are at high risk of cardiovascular disease and the risk isamplified in the presence of nephropathy, which may be partially attributed tomodifications in lipoproteins. Moreover, lipoprotein profile may be affected byincipient nephropathy, glomerulopathy, and mild or severe renal failure. The aim of our study was to evaluate whether chronic renal failure (CRF) changeslipoprotein profile and apo A-I urinary excretion in diabetic subjects withglomerulopathy in comparison with non-diabetic subjects with glomerulopathy andCRF. Diabetic (n=25) and non-diabetic (n=10) patients with glomerulopathy and CRFshowed significantly higher LDL-cholesterol, non-HDL-cholesterol andHDL-triglyceride levels than diabetic individuals without CRF (n=10).Arylesterase and paraoxonase activities did not show any difference betweengroups. Apo A-I could not be detected in urine samples from diabetic patientswithout CRF. All diabetic subjects with glomerulopathy and CRF who presentedproteinuria above 6.5 g/24 h showed detectable urinary apo A-I (range=13.1-61.0mg/24 h). Similarly, all non-diabetic patients with glomerulopathy and CRF whohad proteinuria above 8.0 g/24 h also evidenced detectable apo A-I in urine(range=25.6-557.3 mg/24 h). Urinary apo A-I showed positive and significantcorrelations with urea (r=0.73, p<0.05) and proteinuria (r=0.97, p<0.0001), and anegative correlation with albumin plasma levels (r=-0.68, p<0.05). In conclusion,the presence of CRF in diabetic patients was associated with a more atherogeniclipoprotein profile.Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernández, Karina M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Verona, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Malusardi, María C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Ischoff, Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Beresan, Hugo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Elbert, Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Wikinski, Regina L.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaElsevier Ireland2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/241966Brites, Fernando Daniel; Fernández, Karina M.; Verona, Julián; Malusardi, María C.; Ischoff, Paula; et al.; Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis; Elsevier Ireland; Diabetes Research and Clinical Practice; 75; 1; 12-2007; 35-410168-8227CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168822706002282info:eu-repo/semantics/altIdentifier/doi/10.1016/j.diabres.2006.05.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:38Zoai:ri.conicet.gov.ar:11336/241966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:39.143CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis
title Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis
spellingShingle Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis
Brites, Fernando Daniel
Chronic renal failure
diabetes
lipoproteins
atherosclerosis
title_short Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis
title_full Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis
title_fullStr Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis
title_full_unstemmed Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis
title_sort Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis
dc.creator.none.fl_str_mv Brites, Fernando Daniel
Fernández, Karina M.
Verona, Julián
Malusardi, María C.
Ischoff, Paula
Beresan, Hugo
Elbert, Alicia
Wikinski, Regina L.
author Brites, Fernando Daniel
author_facet Brites, Fernando Daniel
Fernández, Karina M.
Verona, Julián
Malusardi, María C.
Ischoff, Paula
Beresan, Hugo
Elbert, Alicia
Wikinski, Regina L.
author_role author
author2 Fernández, Karina M.
Verona, Julián
Malusardi, María C.
Ischoff, Paula
Beresan, Hugo
Elbert, Alicia
Wikinski, Regina L.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chronic renal failure
diabetes
lipoproteins
atherosclerosis
topic Chronic renal failure
diabetes
lipoproteins
atherosclerosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Diabetic patients are at high risk of cardiovascular disease and the risk isamplified in the presence of nephropathy, which may be partially attributed tomodifications in lipoproteins. Moreover, lipoprotein profile may be affected byincipient nephropathy, glomerulopathy, and mild or severe renal failure. The aim of our study was to evaluate whether chronic renal failure (CRF) changeslipoprotein profile and apo A-I urinary excretion in diabetic subjects withglomerulopathy in comparison with non-diabetic subjects with glomerulopathy andCRF. Diabetic (n=25) and non-diabetic (n=10) patients with glomerulopathy and CRFshowed significantly higher LDL-cholesterol, non-HDL-cholesterol andHDL-triglyceride levels than diabetic individuals without CRF (n=10).Arylesterase and paraoxonase activities did not show any difference betweengroups. Apo A-I could not be detected in urine samples from diabetic patientswithout CRF. All diabetic subjects with glomerulopathy and CRF who presentedproteinuria above 6.5 g/24 h showed detectable urinary apo A-I (range=13.1-61.0mg/24 h). Similarly, all non-diabetic patients with glomerulopathy and CRF whohad proteinuria above 8.0 g/24 h also evidenced detectable apo A-I in urine(range=25.6-557.3 mg/24 h). Urinary apo A-I showed positive and significantcorrelations with urea (r=0.73, p<0.05) and proteinuria (r=0.97, p<0.0001), and anegative correlation with albumin plasma levels (r=-0.68, p<0.05). In conclusion,the presence of CRF in diabetic patients was associated with a more atherogeniclipoprotein profile.
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández, Karina M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Verona, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Malusardi, María C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Ischoff, Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Beresan, Hugo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Elbert, Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Wikinski, Regina L.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
description Diabetic patients are at high risk of cardiovascular disease and the risk isamplified in the presence of nephropathy, which may be partially attributed tomodifications in lipoproteins. Moreover, lipoprotein profile may be affected byincipient nephropathy, glomerulopathy, and mild or severe renal failure. The aim of our study was to evaluate whether chronic renal failure (CRF) changeslipoprotein profile and apo A-I urinary excretion in diabetic subjects withglomerulopathy in comparison with non-diabetic subjects with glomerulopathy andCRF. Diabetic (n=25) and non-diabetic (n=10) patients with glomerulopathy and CRFshowed significantly higher LDL-cholesterol, non-HDL-cholesterol andHDL-triglyceride levels than diabetic individuals without CRF (n=10).Arylesterase and paraoxonase activities did not show any difference betweengroups. Apo A-I could not be detected in urine samples from diabetic patientswithout CRF. All diabetic subjects with glomerulopathy and CRF who presentedproteinuria above 6.5 g/24 h showed detectable urinary apo A-I (range=13.1-61.0mg/24 h). Similarly, all non-diabetic patients with glomerulopathy and CRF whohad proteinuria above 8.0 g/24 h also evidenced detectable apo A-I in urine(range=25.6-557.3 mg/24 h). Urinary apo A-I showed positive and significantcorrelations with urea (r=0.73, p<0.05) and proteinuria (r=0.97, p<0.0001), and anegative correlation with albumin plasma levels (r=-0.68, p<0.05). In conclusion,the presence of CRF in diabetic patients was associated with a more atherogeniclipoprotein profile.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241966
Brites, Fernando Daniel; Fernández, Karina M.; Verona, Julián; Malusardi, María C.; Ischoff, Paula; et al.; Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis; Elsevier Ireland; Diabetes Research and Clinical Practice; 75; 1; 12-2007; 35-41
0168-8227
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241966
identifier_str_mv Brites, Fernando Daniel; Fernández, Karina M.; Verona, Julián; Malusardi, María C.; Ischoff, Paula; et al.; Chronic renal failure in diabetic patients increases lipid risk factors for atherosclerosis; Elsevier Ireland; Diabetes Research and Clinical Practice; 75; 1; 12-2007; 35-41
0168-8227
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168822706002282
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.diabres.2006.05.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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