Altered elimination of organic anions in rats with chornic renal failure

Autores
Torres, Adriana Mónica; Mac Laughlin, Myriam Alicia; Muller, Angelica del Carmen; Brandoni, Anabel; Anzai, Naohiko; Endou, Hitoshi
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The progress of chronic renal failure (CRF) is characterized by the development of glomerular and tubular lesions. However, little is known about the expression of organic anions renal transporters. The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). Two groups of animals were used: Sham and CRF. Six months after surgery, systolic blood pressure and plasma creatinine concentrations were significantly higher in CRF groups. CRF rats showed a diminution in: the filtered, secreted and excreted load of PAH; the systemic clearance of PAH; the renal OAT1 expression; and the renal Na-K-ATPase activity. No remarkable modifications were observed in the OAT3 expression from CRF kidneys. The diminution in the systemic depuration and renal excretion of PAH may be explained by the decrease in its filtered and secreted load. The lower OAT1 expression in remnant renal mass of CRF rats or/and the lower activity of Na-K-ATPase might justify, at least in part, the diminished secreted load of this organic anion.
Fil: Torres, Adriana Mónica. Universidad Nacional de Rosario; Argentina
Fil: Mac Laughlin, Myriam Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Brandoni, Anabel. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Anzai, Naohiko. Kyorin University; Japón
Fil: Endou, Hitoshi. Kyorin University; Japón
Materia
CHRONIC RENAL FAILURE
ORGANIC ANION
ORGANIC ANION TRANSPORTER 1
ORGANIC ANION TRANSPORTER 3
RENAL DEPURATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/149481
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/149481
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Altered elimination of organic anions in rats with chornic renal failureTorres, Adriana MónicaMac Laughlin, Myriam AliciaMuller, Angelica del CarmenBrandoni, AnabelAnzai, NaohikoEndou, HitoshiCHRONIC RENAL FAILUREORGANIC ANIONORGANIC ANION TRANSPORTER 1ORGANIC ANION TRANSPORTER 3RENAL DEPURATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The progress of chronic renal failure (CRF) is characterized by the development of glomerular and tubular lesions. However, little is known about the expression of organic anions renal transporters. The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). Two groups of animals were used: Sham and CRF. Six months after surgery, systolic blood pressure and plasma creatinine concentrations were significantly higher in CRF groups. CRF rats showed a diminution in: the filtered, secreted and excreted load of PAH; the systemic clearance of PAH; the renal OAT1 expression; and the renal Na-K-ATPase activity. No remarkable modifications were observed in the OAT3 expression from CRF kidneys. The diminution in the systemic depuration and renal excretion of PAH may be explained by the decrease in its filtered and secreted load. The lower OAT1 expression in remnant renal mass of CRF rats or/and the lower activity of Na-K-ATPase might justify, at least in part, the diminished secreted load of this organic anion.Fil: Torres, Adriana Mónica. Universidad Nacional de Rosario; ArgentinaFil: Mac Laughlin, Myriam Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Brandoni, Anabel. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Anzai, Naohiko. Kyorin University; JapónFil: Endou, Hitoshi. Kyorin University; JapónElsevier Science2005-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/149481Torres, Adriana Mónica; Mac Laughlin, Myriam Alicia; Muller, Angelica del Carmen; Brandoni, Anabel; Anzai, Naohiko; et al.; Altered elimination of organic anions in rats with chornic renal failure; Elsevier Science; Biochimica et Biophysica Acta - Molecular Basis of Disease; 1740; 1; 4-2005; 29-370925-4439CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0925443905000219info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbadis.2005.03.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:46Zoai:ri.conicet.gov.ar:11336/149481instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:47.107CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Altered elimination of organic anions in rats with chornic renal failure
title Altered elimination of organic anions in rats with chornic renal failure
spellingShingle Altered elimination of organic anions in rats with chornic renal failure
Torres, Adriana Mónica
CHRONIC RENAL FAILURE
ORGANIC ANION
ORGANIC ANION TRANSPORTER 1
ORGANIC ANION TRANSPORTER 3
RENAL DEPURATION
title_short Altered elimination of organic anions in rats with chornic renal failure
title_full Altered elimination of organic anions in rats with chornic renal failure
title_fullStr Altered elimination of organic anions in rats with chornic renal failure
title_full_unstemmed Altered elimination of organic anions in rats with chornic renal failure
title_sort Altered elimination of organic anions in rats with chornic renal failure
dc.creator.none.fl_str_mv Torres, Adriana Mónica
Mac Laughlin, Myriam Alicia
Muller, Angelica del Carmen
Brandoni, Anabel
Anzai, Naohiko
Endou, Hitoshi
author Torres, Adriana Mónica
author_facet Torres, Adriana Mónica
Mac Laughlin, Myriam Alicia
Muller, Angelica del Carmen
Brandoni, Anabel
Anzai, Naohiko
Endou, Hitoshi
author_role author
author2 Mac Laughlin, Myriam Alicia
Muller, Angelica del Carmen
Brandoni, Anabel
Anzai, Naohiko
Endou, Hitoshi
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHRONIC RENAL FAILURE
ORGANIC ANION
ORGANIC ANION TRANSPORTER 1
ORGANIC ANION TRANSPORTER 3
RENAL DEPURATION
topic CHRONIC RENAL FAILURE
ORGANIC ANION
ORGANIC ANION TRANSPORTER 1
ORGANIC ANION TRANSPORTER 3
RENAL DEPURATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The progress of chronic renal failure (CRF) is characterized by the development of glomerular and tubular lesions. However, little is known about the expression of organic anions renal transporters. The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). Two groups of animals were used: Sham and CRF. Six months after surgery, systolic blood pressure and plasma creatinine concentrations were significantly higher in CRF groups. CRF rats showed a diminution in: the filtered, secreted and excreted load of PAH; the systemic clearance of PAH; the renal OAT1 expression; and the renal Na-K-ATPase activity. No remarkable modifications were observed in the OAT3 expression from CRF kidneys. The diminution in the systemic depuration and renal excretion of PAH may be explained by the decrease in its filtered and secreted load. The lower OAT1 expression in remnant renal mass of CRF rats or/and the lower activity of Na-K-ATPase might justify, at least in part, the diminished secreted load of this organic anion.
Fil: Torres, Adriana Mónica. Universidad Nacional de Rosario; Argentina
Fil: Mac Laughlin, Myriam Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Brandoni, Anabel. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Anzai, Naohiko. Kyorin University; Japón
Fil: Endou, Hitoshi. Kyorin University; Japón
description The progress of chronic renal failure (CRF) is characterized by the development of glomerular and tubular lesions. However, little is known about the expression of organic anions renal transporters. The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). Two groups of animals were used: Sham and CRF. Six months after surgery, systolic blood pressure and plasma creatinine concentrations were significantly higher in CRF groups. CRF rats showed a diminution in: the filtered, secreted and excreted load of PAH; the systemic clearance of PAH; the renal OAT1 expression; and the renal Na-K-ATPase activity. No remarkable modifications were observed in the OAT3 expression from CRF kidneys. The diminution in the systemic depuration and renal excretion of PAH may be explained by the decrease in its filtered and secreted load. The lower OAT1 expression in remnant renal mass of CRF rats or/and the lower activity of Na-K-ATPase might justify, at least in part, the diminished secreted load of this organic anion.
publishDate 2005
dc.date.none.fl_str_mv 2005-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/149481
Torres, Adriana Mónica; Mac Laughlin, Myriam Alicia; Muller, Angelica del Carmen; Brandoni, Anabel; Anzai, Naohiko; et al.; Altered elimination of organic anions in rats with chornic renal failure; Elsevier Science; Biochimica et Biophysica Acta - Molecular Basis of Disease; 1740; 1; 4-2005; 29-37
0925-4439
CONICET Digital
CONICET
url http://hdl.handle.net/11336/149481
identifier_str_mv Torres, Adriana Mónica; Mac Laughlin, Myriam Alicia; Muller, Angelica del Carmen; Brandoni, Anabel; Anzai, Naohiko; et al.; Altered elimination of organic anions in rats with chornic renal failure; Elsevier Science; Biochimica et Biophysica Acta - Molecular Basis of Disease; 1740; 1; 4-2005; 29-37
0925-4439
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0925443905000219
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbadis.2005.03.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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