Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus

Autores
Furio, Analía Mabel; Fontao, Ramiro; Falco, Nicolás; Ruiz, Juan I.; Caccuri, Roberto Luis; Cardinali, Daniel Pedro
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dexamethasone has a neurotoxic action on rodent hippocampus. The objective of this study was to examine the extent of neuroprotection exerted by melatonin on that neurotoxic effect. A group of 24 rats received 9 daily subcutaneous injections of 0.5 mg/kg of dexamethasone. Half of them received 25 ìg/ml of melatonin in the drinking water for 10 days. Controls included rats injected with vehicle or rats injected with vehicle plus melatonin in the drinking water. At the end of treatment, the brains were processed for a morphometric analysis, the results being expressed as percent number of abnormal hipoccampal neurons (defined as necrotic cells) per field. Melatonin decreased by 77 % the effect of dexamethasone (p< 0.001). A laterality of neurotoxic effect of dexamethasone was apparent in rats that did not receive melatonin (percent of necrotic cells in left and right hippocampus: 32.0 ± 4.4 and 19.6 ± 1.9 %, respectively, p< 0.01). The results indicate a protective effect of melatonin on glucocorticoid neurotoxicity in the rat hippocampus.
Fil: Furio, Analía Mabel. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Fontao, Ramiro. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Falco, Nicolás. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Ruiz, Juan I.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Caccuri, Roberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Materia
MELATONIN
NEUROPROTECTION
HIPOCCAMPUS
CORTICOID NEUROTOXICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/282487
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampusFurio, Analía MabelFontao, RamiroFalco, NicolásRuiz, Juan I.Caccuri, Roberto LuisCardinali, Daniel PedroMELATONINNEUROPROTECTIONHIPOCCAMPUSCORTICOID NEUROTOXICITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Dexamethasone has a neurotoxic action on rodent hippocampus. The objective of this study was to examine the extent of neuroprotection exerted by melatonin on that neurotoxic effect. A group of 24 rats received 9 daily subcutaneous injections of 0.5 mg/kg of dexamethasone. Half of them received 25 ìg/ml of melatonin in the drinking water for 10 days. Controls included rats injected with vehicle or rats injected with vehicle plus melatonin in the drinking water. At the end of treatment, the brains were processed for a morphometric analysis, the results being expressed as percent number of abnormal hipoccampal neurons (defined as necrotic cells) per field. Melatonin decreased by 77 % the effect of dexamethasone (p< 0.001). A laterality of neurotoxic effect of dexamethasone was apparent in rats that did not receive melatonin (percent of necrotic cells in left and right hippocampus: 32.0 ± 4.4 and 19.6 ± 1.9 %, respectively, p< 0.01). The results indicate a protective effect of melatonin on glucocorticoid neurotoxicity in the rat hippocampus.Fil: Furio, Analía Mabel. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Fontao, Ramiro. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Falco, Nicolás. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Ruiz, Juan I.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Caccuri, Roberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaBentham Science Publishers2008-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/282487Furio, Analía Mabel; Fontao, Ramiro; Falco, Nicolás; Ruiz, Juan I.; Caccuri, Roberto Luis; et al.; Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus; Bentham Science Publishers; The Open Physiology Journal; 1; 4-2008; 23-271874-3609CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.benthamopenarchives.com/abstract.php?ArticleCode=TOPHYJ-1-23info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-31T15:21:10Zoai:ri.conicet.gov.ar:11336/282487instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-31 15:21:10.407CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
title Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
spellingShingle Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
Furio, Analía Mabel
MELATONIN
NEUROPROTECTION
HIPOCCAMPUS
CORTICOID NEUROTOXICITY
title_short Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
title_full Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
title_fullStr Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
title_full_unstemmed Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
title_sort Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
dc.creator.none.fl_str_mv Furio, Analía Mabel
Fontao, Ramiro
Falco, Nicolás
Ruiz, Juan I.
Caccuri, Roberto Luis
Cardinali, Daniel Pedro
author Furio, Analía Mabel
author_facet Furio, Analía Mabel
Fontao, Ramiro
Falco, Nicolás
Ruiz, Juan I.
Caccuri, Roberto Luis
Cardinali, Daniel Pedro
author_role author
author2 Fontao, Ramiro
Falco, Nicolás
Ruiz, Juan I.
Caccuri, Roberto Luis
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv MELATONIN
NEUROPROTECTION
HIPOCCAMPUS
CORTICOID NEUROTOXICITY
topic MELATONIN
NEUROPROTECTION
HIPOCCAMPUS
CORTICOID NEUROTOXICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Dexamethasone has a neurotoxic action on rodent hippocampus. The objective of this study was to examine the extent of neuroprotection exerted by melatonin on that neurotoxic effect. A group of 24 rats received 9 daily subcutaneous injections of 0.5 mg/kg of dexamethasone. Half of them received 25 ìg/ml of melatonin in the drinking water for 10 days. Controls included rats injected with vehicle or rats injected with vehicle plus melatonin in the drinking water. At the end of treatment, the brains were processed for a morphometric analysis, the results being expressed as percent number of abnormal hipoccampal neurons (defined as necrotic cells) per field. Melatonin decreased by 77 % the effect of dexamethasone (p< 0.001). A laterality of neurotoxic effect of dexamethasone was apparent in rats that did not receive melatonin (percent of necrotic cells in left and right hippocampus: 32.0 ± 4.4 and 19.6 ± 1.9 %, respectively, p< 0.01). The results indicate a protective effect of melatonin on glucocorticoid neurotoxicity in the rat hippocampus.
Fil: Furio, Analía Mabel. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Fontao, Ramiro. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Falco, Nicolás. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Ruiz, Juan I.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Caccuri, Roberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
description Dexamethasone has a neurotoxic action on rodent hippocampus. The objective of this study was to examine the extent of neuroprotection exerted by melatonin on that neurotoxic effect. A group of 24 rats received 9 daily subcutaneous injections of 0.5 mg/kg of dexamethasone. Half of them received 25 ìg/ml of melatonin in the drinking water for 10 days. Controls included rats injected with vehicle or rats injected with vehicle plus melatonin in the drinking water. At the end of treatment, the brains were processed for a morphometric analysis, the results being expressed as percent number of abnormal hipoccampal neurons (defined as necrotic cells) per field. Melatonin decreased by 77 % the effect of dexamethasone (p< 0.001). A laterality of neurotoxic effect of dexamethasone was apparent in rats that did not receive melatonin (percent of necrotic cells in left and right hippocampus: 32.0 ± 4.4 and 19.6 ± 1.9 %, respectively, p< 0.01). The results indicate a protective effect of melatonin on glucocorticoid neurotoxicity in the rat hippocampus.
publishDate 2008
dc.date.none.fl_str_mv 2008-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/282487
Furio, Analía Mabel; Fontao, Ramiro; Falco, Nicolás; Ruiz, Juan I.; Caccuri, Roberto Luis; et al.; Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus; Bentham Science Publishers; The Open Physiology Journal; 1; 4-2008; 23-27
1874-3609
CONICET Digital
CONICET
url http://hdl.handle.net/11336/282487
identifier_str_mv Furio, Analía Mabel; Fontao, Ramiro; Falco, Nicolás; Ruiz, Juan I.; Caccuri, Roberto Luis; et al.; Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus; Bentham Science Publishers; The Open Physiology Journal; 1; 4-2008; 23-27
1874-3609
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.benthamopenarchives.com/abstract.php?ArticleCode=TOPHYJ-1-23
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.822162

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