Neuroprotective actions of estradiol revisited

Autores
Azcoitia, Iñigo; Arevalo, Maria Angeles; de Nicola, Alejandro Federico; Garcia Segura, Luis M.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural cells has recently clarified the causes of this discrepancy. New data indicate that estradiol may lose its neuroprotective activity or even increase neural damage, a situation that depends on the duration of ovarian hormone deprivation and on age-associated modifications in the levels of other molecules that modulate estradiol action. These studies highlight the complex neuroprotective mechanisms of estradiol and suggest a window of opportunity during which effective hormonal therapy could promote brain function and cognition.
Fil: Azcoitia, Iñigo. Universidad Complutense de Madrid. Facultad de Biologia; España
Fil: Arevalo, Maria Angeles. Consejo Superior de Investigaciones Cientificas; España
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Garcia Segura, Luis M.. Universidad Complutense de Madrid. Facultad de Biologia; España
Materia
Estradiol
Neuroprotection
Aging
Hippocampus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11212
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/11212
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neuroprotective actions of estradiol revisitedAzcoitia, IñigoArevalo, Maria Angelesde Nicola, Alejandro FedericoGarcia Segura, Luis M.EstradiolNeuroprotectionAgingHippocampushttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural cells has recently clarified the causes of this discrepancy. New data indicate that estradiol may lose its neuroprotective activity or even increase neural damage, a situation that depends on the duration of ovarian hormone deprivation and on age-associated modifications in the levels of other molecules that modulate estradiol action. These studies highlight the complex neuroprotective mechanisms of estradiol and suggest a window of opportunity during which effective hormonal therapy could promote brain function and cognition.Fil: Azcoitia, Iñigo. Universidad Complutense de Madrid. Facultad de Biologia; EspañaFil: Arevalo, Maria Angeles. Consejo Superior de Investigaciones Cientificas; EspañaFil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Garcia Segura, Luis M.. Universidad Complutense de Madrid. Facultad de Biologia; EspañaElsevier2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11212Azcoitia, Iñigo ; Arevalo, Maria Angeles; de Nicola, Alejandro Federico; Garcia Segura, Luis M.; Neuroprotective actions of estradiol revisited; Elsevier; Cell; 22; 12; 12-2011; 467-4731043-2760enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1043276011001202info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tem.2011.08.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:39Zoai:ri.conicet.gov.ar:11336/11212instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:40.206CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuroprotective actions of estradiol revisited
title Neuroprotective actions of estradiol revisited
spellingShingle Neuroprotective actions of estradiol revisited
Azcoitia, Iñigo
Estradiol
Neuroprotection
Aging
Hippocampus
title_short Neuroprotective actions of estradiol revisited
title_full Neuroprotective actions of estradiol revisited
title_fullStr Neuroprotective actions of estradiol revisited
title_full_unstemmed Neuroprotective actions of estradiol revisited
title_sort Neuroprotective actions of estradiol revisited
dc.creator.none.fl_str_mv Azcoitia, Iñigo
Arevalo, Maria Angeles
de Nicola, Alejandro Federico
Garcia Segura, Luis M.
author Azcoitia, Iñigo
author_facet Azcoitia, Iñigo
Arevalo, Maria Angeles
de Nicola, Alejandro Federico
Garcia Segura, Luis M.
author_role author
author2 Arevalo, Maria Angeles
de Nicola, Alejandro Federico
Garcia Segura, Luis M.
author2_role author
author
author
dc.subject.none.fl_str_mv Estradiol
Neuroprotection
Aging
Hippocampus
topic Estradiol
Neuroprotection
Aging
Hippocampus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural cells has recently clarified the causes of this discrepancy. New data indicate that estradiol may lose its neuroprotective activity or even increase neural damage, a situation that depends on the duration of ovarian hormone deprivation and on age-associated modifications in the levels of other molecules that modulate estradiol action. These studies highlight the complex neuroprotective mechanisms of estradiol and suggest a window of opportunity during which effective hormonal therapy could promote brain function and cognition.
Fil: Azcoitia, Iñigo. Universidad Complutense de Madrid. Facultad de Biologia; España
Fil: Arevalo, Maria Angeles. Consejo Superior de Investigaciones Cientificas; España
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Garcia Segura, Luis M.. Universidad Complutense de Madrid. Facultad de Biologia; España
description Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural cells has recently clarified the causes of this discrepancy. New data indicate that estradiol may lose its neuroprotective activity or even increase neural damage, a situation that depends on the duration of ovarian hormone deprivation and on age-associated modifications in the levels of other molecules that modulate estradiol action. These studies highlight the complex neuroprotective mechanisms of estradiol and suggest a window of opportunity during which effective hormonal therapy could promote brain function and cognition.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11212
Azcoitia, Iñigo ; Arevalo, Maria Angeles; de Nicola, Alejandro Federico; Garcia Segura, Luis M.; Neuroprotective actions of estradiol revisited; Elsevier; Cell; 22; 12; 12-2011; 467-473
1043-2760
url http://hdl.handle.net/11336/11212
identifier_str_mv Azcoitia, Iñigo ; Arevalo, Maria Angeles; de Nicola, Alejandro Federico; Garcia Segura, Luis M.; Neuroprotective actions of estradiol revisited; Elsevier; Cell; 22; 12; 12-2011; 467-473
1043-2760
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1043276011001202
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tem.2011.08.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270129084170240
score 13.13397

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