Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models

Autores
Lopez Hernandez, Javier E.; Nayeem, Nazia; Cerón Carrasco, José P.; Ahad, Afruja; Hafeed, Aiman; Leon, Ignacio Esteban; Contel, Maria
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
New heterometallic binuclear and trinuclear platinum(IV)–gold(I) compounds of the type [Pt(L)nCl2(OH){(OOC-4-C6H4-PPh2)AuCl}x] (L=NH3, n=2; x=1, 2; L=diaminocyclohexane, DACH, n=1; x=2) are described. These compounds are cytotoxic and selective against a small panel of renal, bladder, ovarian, and breast cancer cell lines. We selected a trinuclear PtAu2 compound containing the PtIV core based on oxaliplatin, to further investigate its cell-death pathway, cell and organelle uptake and anticancer effects against the triple-negative breast cancer (TNBC) MDA-MB-231 cell line. This compound induces apoptosis and accumulates mainly in the nucleus and mitochondria. It also exerts remarkable antimigratory and antiangiogenic properties, and has a potent cytotoxic effect against TNBC 3D spheroids. Trinuclear compounds do not seem to display relevant interactions with calf thymus (CT) DNA and plasmid (pBR322) even in the presence of reducing agents, but inhibit pro-angiogenic enzyme thioredoxin reductase (TrxR) in TNBC cells.
Fil: Lopez Hernandez, Javier E.. Brooklyn College ; City University Of New York;
Fil: Nayeem, Nazia. Brooklyn College ; City University Of New York;
Fil: Cerón Carrasco, José P.. Brooklyn College ; City University Of New York;
Fil: Ahad, Afruja. Department Of Chemistry ; Brooklyn College ; City University Of New York;
Fil: Hafeed, Aiman. Department Of Chemistry ; Brooklyn College ; City University Of New York;
Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Contel, Maria. Department Of Chemistry ; Brooklyn College ; City University Of New York;
Materia
CHEMOTHERAPEUTICS
GOLD
HETEROMETALLIC PHOSPHANES
PLATINUM
TNBC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227216
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/227216
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer ModelsLopez Hernandez, Javier E.Nayeem, NaziaCerón Carrasco, José P.Ahad, AfrujaHafeed, AimanLeon, Ignacio EstebanContel, MariaCHEMOTHERAPEUTICSGOLDHETEROMETALLIC PHOSPHANESPLATINUMTNBChttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1New heterometallic binuclear and trinuclear platinum(IV)–gold(I) compounds of the type [Pt(L)nCl2(OH){(OOC-4-C6H4-PPh2)AuCl}x] (L=NH3, n=2; x=1, 2; L=diaminocyclohexane, DACH, n=1; x=2) are described. These compounds are cytotoxic and selective against a small panel of renal, bladder, ovarian, and breast cancer cell lines. We selected a trinuclear PtAu2 compound containing the PtIV core based on oxaliplatin, to further investigate its cell-death pathway, cell and organelle uptake and anticancer effects against the triple-negative breast cancer (TNBC) MDA-MB-231 cell line. This compound induces apoptosis and accumulates mainly in the nucleus and mitochondria. It also exerts remarkable antimigratory and antiangiogenic properties, and has a potent cytotoxic effect against TNBC 3D spheroids. Trinuclear compounds do not seem to display relevant interactions with calf thymus (CT) DNA and plasmid (pBR322) even in the presence of reducing agents, but inhibit pro-angiogenic enzyme thioredoxin reductase (TrxR) in TNBC cells.Fil: Lopez Hernandez, Javier E.. Brooklyn College ; City University Of New York;Fil: Nayeem, Nazia. Brooklyn College ; City University Of New York;Fil: Cerón Carrasco, José P.. Brooklyn College ; City University Of New York;Fil: Ahad, Afruja. Department Of Chemistry ; Brooklyn College ; City University Of New York;Fil: Hafeed, Aiman. Department Of Chemistry ; Brooklyn College ; City University Of New York;Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Contel, Maria. Department Of Chemistry ; Brooklyn College ; City University Of New York;Wiley VCH Verlag2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227216Lopez Hernandez, Javier E.; Nayeem, Nazia; Cerón Carrasco, José P.; Ahad, Afruja; Hafeed, Aiman; et al.; Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models; Wiley VCH Verlag; Chemistry- A European Journal; 29; 59; 7-2023; 1-160947-6539CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202302045info:eu-repo/semantics/altIdentifier/doi/10.1002/chem.202302045info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:50:19Zoai:ri.conicet.gov.ar:11336/227216instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:50:19.697CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models
title Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models
spellingShingle Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models
Lopez Hernandez, Javier E.
CHEMOTHERAPEUTICS
GOLD
HETEROMETALLIC PHOSPHANES
PLATINUM
TNBC
title_short Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models
title_full Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models
title_fullStr Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models
title_full_unstemmed Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models
title_sort Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models
dc.creator.none.fl_str_mv Lopez Hernandez, Javier E.
Nayeem, Nazia
Cerón Carrasco, José P.
Ahad, Afruja
Hafeed, Aiman
Leon, Ignacio Esteban
Contel, Maria
author Lopez Hernandez, Javier E.
author_facet Lopez Hernandez, Javier E.
Nayeem, Nazia
Cerón Carrasco, José P.
Ahad, Afruja
Hafeed, Aiman
Leon, Ignacio Esteban
Contel, Maria
author_role author
author2 Nayeem, Nazia
Cerón Carrasco, José P.
Ahad, Afruja
Hafeed, Aiman
Leon, Ignacio Esteban
Contel, Maria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CHEMOTHERAPEUTICS
GOLD
HETEROMETALLIC PHOSPHANES
PLATINUM
TNBC
topic CHEMOTHERAPEUTICS
GOLD
HETEROMETALLIC PHOSPHANES
PLATINUM
TNBC
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv New heterometallic binuclear and trinuclear platinum(IV)–gold(I) compounds of the type [Pt(L)nCl2(OH){(OOC-4-C6H4-PPh2)AuCl}x] (L=NH3, n=2; x=1, 2; L=diaminocyclohexane, DACH, n=1; x=2) are described. These compounds are cytotoxic and selective against a small panel of renal, bladder, ovarian, and breast cancer cell lines. We selected a trinuclear PtAu2 compound containing the PtIV core based on oxaliplatin, to further investigate its cell-death pathway, cell and organelle uptake and anticancer effects against the triple-negative breast cancer (TNBC) MDA-MB-231 cell line. This compound induces apoptosis and accumulates mainly in the nucleus and mitochondria. It also exerts remarkable antimigratory and antiangiogenic properties, and has a potent cytotoxic effect against TNBC 3D spheroids. Trinuclear compounds do not seem to display relevant interactions with calf thymus (CT) DNA and plasmid (pBR322) even in the presence of reducing agents, but inhibit pro-angiogenic enzyme thioredoxin reductase (TrxR) in TNBC cells.
Fil: Lopez Hernandez, Javier E.. Brooklyn College ; City University Of New York;
Fil: Nayeem, Nazia. Brooklyn College ; City University Of New York;
Fil: Cerón Carrasco, José P.. Brooklyn College ; City University Of New York;
Fil: Ahad, Afruja. Department Of Chemistry ; Brooklyn College ; City University Of New York;
Fil: Hafeed, Aiman. Department Of Chemistry ; Brooklyn College ; City University Of New York;
Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Contel, Maria. Department Of Chemistry ; Brooklyn College ; City University Of New York;
description New heterometallic binuclear and trinuclear platinum(IV)–gold(I) compounds of the type [Pt(L)nCl2(OH){(OOC-4-C6H4-PPh2)AuCl}x] (L=NH3, n=2; x=1, 2; L=diaminocyclohexane, DACH, n=1; x=2) are described. These compounds are cytotoxic and selective against a small panel of renal, bladder, ovarian, and breast cancer cell lines. We selected a trinuclear PtAu2 compound containing the PtIV core based on oxaliplatin, to further investigate its cell-death pathway, cell and organelle uptake and anticancer effects against the triple-negative breast cancer (TNBC) MDA-MB-231 cell line. This compound induces apoptosis and accumulates mainly in the nucleus and mitochondria. It also exerts remarkable antimigratory and antiangiogenic properties, and has a potent cytotoxic effect against TNBC 3D spheroids. Trinuclear compounds do not seem to display relevant interactions with calf thymus (CT) DNA and plasmid (pBR322) even in the presence of reducing agents, but inhibit pro-angiogenic enzyme thioredoxin reductase (TrxR) in TNBC cells.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227216
Lopez Hernandez, Javier E.; Nayeem, Nazia; Cerón Carrasco, José P.; Ahad, Afruja; Hafeed, Aiman; et al.; Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models; Wiley VCH Verlag; Chemistry- A European Journal; 29; 59; 7-2023; 1-16
0947-6539
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227216
identifier_str_mv Lopez Hernandez, Javier E.; Nayeem, Nazia; Cerón Carrasco, José P.; Ahad, Afruja; Hafeed, Aiman; et al.; Platinum(IV)–Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models; Wiley VCH Verlag; Chemistry- A European Journal; 29; 59; 7-2023; 1-16
0947-6539
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202302045
info:eu-repo/semantics/altIdentifier/doi/10.1002/chem.202302045
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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