Effects of systolic blood pressure on brain integrity in multiple sclerosis

Autores
Dossi, Daiana; Chaves, Hernán; Heck, Evelyn Sabrina; Rodriguez Murua, Sofia; Ventrice, Fernando; Bakshi, Rohit; Quintana, Francisco Javier; Correale, Jorge; Farez, Mauricio Franco
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: In MS patients, hypertension is associated with a delayed diagnosis and an increased risk of progression. Understanding the mechanisms of this association could potentially lead to improved prevention of disease progression. We aimed to establish whether high blood pressure contributes to white-matter injury and brain atrophy in MS. Methods: Cross-sectional study of 95 patients with RRMS. Estimates of fractional anisotropy, gray-matter volume and lesion load were obtained from 3T MRI. We used fractional anisotropy voxel-based statistics to establish the effect of blood pressure on white matter tracts. Additionally, we used voxel-based morphometry (VBM) to study the effect on gray matter integrity. Results: Only 29.5% had normal blood pressure levels, with 52.6% suffering from prehypertension and 17.9% with hypertension. Increasing systolic blood pressure was associated with damage to posterior white-matter tracts as well as greater levels of gray matter atrophy, in particular in the frontal cortex. Age-adjusted linear regression indicated that neither lesion volume (β = 0.002, 95%CI: 0.02-0.02; p = 0.85) or lesion number (β = -0.004, 95%CI: 0.03-0.02; p = 0.74) were associated with systolic blood pressure. Conclusions: Prehypertension and hypertension are frequent in MS. Increased blood pressure is related to white- and gray-matter integrity, both related to MS disability outcomes. These findings suggest attention to the control of blood pressure in MS patients.
Fil: Dossi, Daiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Chaves, Hernán. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Heck, Evelyn Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Rodriguez Murua, Sofia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ventrice, Fernando. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bakshi, Rohit. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Quintana, Francisco Javier. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Correale, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Farez, Mauricio Franco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
Materia
FRACTIONAL ANISOTROPHY
HYPERTENSION
MULTIPLE SCLEROSIS
SYSTOLIC BLOOD PRESSURE
WHITE-MATTER INTEGRITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182929
Acceder
id CONICETDig_f4d6c608d0c0e9cb76ed63fbe52835c0
oai_identifier_str oai:ri.conicet.gov.ar:11336/182929
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of systolic blood pressure on brain integrity in multiple sclerosisDossi, DaianaChaves, HernánHeck, Evelyn SabrinaRodriguez Murua, SofiaVentrice, FernandoBakshi, RohitQuintana, Francisco JavierCorreale, JorgeFarez, Mauricio FrancoFRACTIONAL ANISOTROPHYHYPERTENSIONMULTIPLE SCLEROSISSYSTOLIC BLOOD PRESSUREWHITE-MATTER INTEGRITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: In MS patients, hypertension is associated with a delayed diagnosis and an increased risk of progression. Understanding the mechanisms of this association could potentially lead to improved prevention of disease progression. We aimed to establish whether high blood pressure contributes to white-matter injury and brain atrophy in MS. Methods: Cross-sectional study of 95 patients with RRMS. Estimates of fractional anisotropy, gray-matter volume and lesion load were obtained from 3T MRI. We used fractional anisotropy voxel-based statistics to establish the effect of blood pressure on white matter tracts. Additionally, we used voxel-based morphometry (VBM) to study the effect on gray matter integrity. Results: Only 29.5% had normal blood pressure levels, with 52.6% suffering from prehypertension and 17.9% with hypertension. Increasing systolic blood pressure was associated with damage to posterior white-matter tracts as well as greater levels of gray matter atrophy, in particular in the frontal cortex. Age-adjusted linear regression indicated that neither lesion volume (β = 0.002, 95%CI: 0.02-0.02; p = 0.85) or lesion number (β = -0.004, 95%CI: 0.03-0.02; p = 0.74) were associated with systolic blood pressure. Conclusions: Prehypertension and hypertension are frequent in MS. Increased blood pressure is related to white- and gray-matter integrity, both related to MS disability outcomes. These findings suggest attention to the control of blood pressure in MS patients.Fil: Dossi, Daiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Chaves, Hernán. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Heck, Evelyn Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Rodriguez Murua, Sofia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ventrice, Fernando. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Bakshi, Rohit. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Quintana, Francisco Javier. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Correale, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Farez, Mauricio Franco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; ArgentinaFrontiers Media S.A.2021-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182929Dossi, Daiana; Chaves, Hernán; Heck, Evelyn Sabrina; Rodriguez Murua, Sofia; Ventrice, Fernando; et al.; Effects of systolic blood pressure on brain integrity in multiple sclerosis; Frontiers Media S.A.; Frontiers in Neurology; 9; 10-2021; 1-81664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2018.00487/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2018.00487info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:10Zoai:ri.conicet.gov.ar:11336/182929instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:10.67CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of systolic blood pressure on brain integrity in multiple sclerosis
title Effects of systolic blood pressure on brain integrity in multiple sclerosis
spellingShingle Effects of systolic blood pressure on brain integrity in multiple sclerosis
Dossi, Daiana
FRACTIONAL ANISOTROPHY
HYPERTENSION
MULTIPLE SCLEROSIS
SYSTOLIC BLOOD PRESSURE
WHITE-MATTER INTEGRITY
title_short Effects of systolic blood pressure on brain integrity in multiple sclerosis
title_full Effects of systolic blood pressure on brain integrity in multiple sclerosis
title_fullStr Effects of systolic blood pressure on brain integrity in multiple sclerosis
title_full_unstemmed Effects of systolic blood pressure on brain integrity in multiple sclerosis
title_sort Effects of systolic blood pressure on brain integrity in multiple sclerosis
dc.creator.none.fl_str_mv Dossi, Daiana
Chaves, Hernán
Heck, Evelyn Sabrina
Rodriguez Murua, Sofia
Ventrice, Fernando
Bakshi, Rohit
Quintana, Francisco Javier
Correale, Jorge
Farez, Mauricio Franco
author Dossi, Daiana
author_facet Dossi, Daiana
Chaves, Hernán
Heck, Evelyn Sabrina
Rodriguez Murua, Sofia
Ventrice, Fernando
Bakshi, Rohit
Quintana, Francisco Javier
Correale, Jorge
Farez, Mauricio Franco
author_role author
author2 Chaves, Hernán
Heck, Evelyn Sabrina
Rodriguez Murua, Sofia
Ventrice, Fernando
Bakshi, Rohit
Quintana, Francisco Javier
Correale, Jorge
Farez, Mauricio Franco
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FRACTIONAL ANISOTROPHY
HYPERTENSION
MULTIPLE SCLEROSIS
SYSTOLIC BLOOD PRESSURE
WHITE-MATTER INTEGRITY
topic FRACTIONAL ANISOTROPHY
HYPERTENSION
MULTIPLE SCLEROSIS
SYSTOLIC BLOOD PRESSURE
WHITE-MATTER INTEGRITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: In MS patients, hypertension is associated with a delayed diagnosis and an increased risk of progression. Understanding the mechanisms of this association could potentially lead to improved prevention of disease progression. We aimed to establish whether high blood pressure contributes to white-matter injury and brain atrophy in MS. Methods: Cross-sectional study of 95 patients with RRMS. Estimates of fractional anisotropy, gray-matter volume and lesion load were obtained from 3T MRI. We used fractional anisotropy voxel-based statistics to establish the effect of blood pressure on white matter tracts. Additionally, we used voxel-based morphometry (VBM) to study the effect on gray matter integrity. Results: Only 29.5% had normal blood pressure levels, with 52.6% suffering from prehypertension and 17.9% with hypertension. Increasing systolic blood pressure was associated with damage to posterior white-matter tracts as well as greater levels of gray matter atrophy, in particular in the frontal cortex. Age-adjusted linear regression indicated that neither lesion volume (β = 0.002, 95%CI: 0.02-0.02; p = 0.85) or lesion number (β = -0.004, 95%CI: 0.03-0.02; p = 0.74) were associated with systolic blood pressure. Conclusions: Prehypertension and hypertension are frequent in MS. Increased blood pressure is related to white- and gray-matter integrity, both related to MS disability outcomes. These findings suggest attention to the control of blood pressure in MS patients.
Fil: Dossi, Daiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Chaves, Hernán. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Heck, Evelyn Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Rodriguez Murua, Sofia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ventrice, Fernando. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bakshi, Rohit. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Quintana, Francisco Javier. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Correale, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Farez, Mauricio Franco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
description Background: In MS patients, hypertension is associated with a delayed diagnosis and an increased risk of progression. Understanding the mechanisms of this association could potentially lead to improved prevention of disease progression. We aimed to establish whether high blood pressure contributes to white-matter injury and brain atrophy in MS. Methods: Cross-sectional study of 95 patients with RRMS. Estimates of fractional anisotropy, gray-matter volume and lesion load were obtained from 3T MRI. We used fractional anisotropy voxel-based statistics to establish the effect of blood pressure on white matter tracts. Additionally, we used voxel-based morphometry (VBM) to study the effect on gray matter integrity. Results: Only 29.5% had normal blood pressure levels, with 52.6% suffering from prehypertension and 17.9% with hypertension. Increasing systolic blood pressure was associated with damage to posterior white-matter tracts as well as greater levels of gray matter atrophy, in particular in the frontal cortex. Age-adjusted linear regression indicated that neither lesion volume (β = 0.002, 95%CI: 0.02-0.02; p = 0.85) or lesion number (β = -0.004, 95%CI: 0.03-0.02; p = 0.74) were associated with systolic blood pressure. Conclusions: Prehypertension and hypertension are frequent in MS. Increased blood pressure is related to white- and gray-matter integrity, both related to MS disability outcomes. These findings suggest attention to the control of blood pressure in MS patients.
publishDate 2021
dc.date.none.fl_str_mv 2021-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182929
Dossi, Daiana; Chaves, Hernán; Heck, Evelyn Sabrina; Rodriguez Murua, Sofia; Ventrice, Fernando; et al.; Effects of systolic blood pressure on brain integrity in multiple sclerosis; Frontiers Media S.A.; Frontiers in Neurology; 9; 10-2021; 1-8
1664-2295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182929
identifier_str_mv Dossi, Daiana; Chaves, Hernán; Heck, Evelyn Sabrina; Rodriguez Murua, Sofia; Ventrice, Fernando; et al.; Effects of systolic blood pressure on brain integrity in multiple sclerosis; Frontiers Media S.A.; Frontiers in Neurology; 9; 10-2021; 1-8
1664-2295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2018.00487/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2018.00487
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613907599065088
score 13.070432

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