Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques

Autores
Cortez Tornello, Pablo Roberto; Caracciolo, Pablo Christian; Cuadrado, Teresita Raquel; Abraham, Gustavo Abel
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Poly(e-caprolactone) micro/nanofibrous scaffolds obtained by electrospinning technique from polymer solutions were characterized in terms of fiber diameter (as measured by scanning electron microscopy - SEM), pore size and its distribution (as measured by liquid extrusion porosimetry), and porosity (as determined by gravimetric measurement, liquid intrusion method, SEM image analysis and liquid extrusion porosimetry - LEP). Nonwoven micro/nanofibrous scaffolds were formed by uniform bead-free fibers with mean diameters in the range of 0.4 to 7 um. The results indicate that pore size and pore size distribution are strongly associated to fiber diameter. Porosity results were analyzed taking into account the accuracy and limitations of each method. LEP resulted the most suitable technique for measuring through-pore diameter and porosity. In order to compare empirical data of pore size from LEP, a theoretical multiplanar model for stochastic fiber networks was applied. The results predicted by the model were in good agreement with the experimental data provided by LEP for pore mean diameters higher than 1 um. The present study shows the potential of LEP as a valuable instrumental technique for characterizing the porous structure of electrospun fibrous scaffolds.
Fil: Cortez Tornello, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Cuadrado, Teresita Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
Electrospinning
Electrospun Scaffold
Liquid Extrusion Porosimetry
Pore Size Distribution
Microstructure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27874
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/27874
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniquesCortez Tornello, Pablo RobertoCaracciolo, Pablo ChristianCuadrado, Teresita RaquelAbraham, Gustavo AbelElectrospinningElectrospun ScaffoldLiquid Extrusion PorosimetryPore Size DistributionMicrostructurehttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Poly(e-caprolactone) micro/nanofibrous scaffolds obtained by electrospinning technique from polymer solutions were characterized in terms of fiber diameter (as measured by scanning electron microscopy - SEM), pore size and its distribution (as measured by liquid extrusion porosimetry), and porosity (as determined by gravimetric measurement, liquid intrusion method, SEM image analysis and liquid extrusion porosimetry - LEP). Nonwoven micro/nanofibrous scaffolds were formed by uniform bead-free fibers with mean diameters in the range of 0.4 to 7 um. The results indicate that pore size and pore size distribution are strongly associated to fiber diameter. Porosity results were analyzed taking into account the accuracy and limitations of each method. LEP resulted the most suitable technique for measuring through-pore diameter and porosity. In order to compare empirical data of pore size from LEP, a theoretical multiplanar model for stochastic fiber networks was applied. The results predicted by the model were in good agreement with the experimental data provided by LEP for pore mean diameters higher than 1 um. The present study shows the potential of LEP as a valuable instrumental technique for characterizing the porous structure of electrospun fibrous scaffolds.Fil: Cortez Tornello, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Cuadrado, Teresita Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaElsevier Science2014-05-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27874Cortez Tornello, Pablo Roberto; Caracciolo, Pablo Christian; Cuadrado, Teresita Raquel; Abraham, Gustavo Abel; Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques; Elsevier Science; Materials Science and Engineering: C; 41; 5-5-2014; 335-3420928-4931CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2014.04.065info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0928493114002574info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0928493114002574?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:22Zoai:ri.conicet.gov.ar:11336/27874instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:23.256CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques
title Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques
spellingShingle Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques
Cortez Tornello, Pablo Roberto
Electrospinning
Electrospun Scaffold
Liquid Extrusion Porosimetry
Pore Size Distribution
Microstructure
title_short Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques
title_full Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques
title_fullStr Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques
title_full_unstemmed Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques
title_sort Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques
dc.creator.none.fl_str_mv Cortez Tornello, Pablo Roberto
Caracciolo, Pablo Christian
Cuadrado, Teresita Raquel
Abraham, Gustavo Abel
author Cortez Tornello, Pablo Roberto
author_facet Cortez Tornello, Pablo Roberto
Caracciolo, Pablo Christian
Cuadrado, Teresita Raquel
Abraham, Gustavo Abel
author_role author
author2 Caracciolo, Pablo Christian
Cuadrado, Teresita Raquel
Abraham, Gustavo Abel
author2_role author
author
author
dc.subject.none.fl_str_mv Electrospinning
Electrospun Scaffold
Liquid Extrusion Porosimetry
Pore Size Distribution
Microstructure
topic Electrospinning
Electrospun Scaffold
Liquid Extrusion Porosimetry
Pore Size Distribution
Microstructure
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Poly(e-caprolactone) micro/nanofibrous scaffolds obtained by electrospinning technique from polymer solutions were characterized in terms of fiber diameter (as measured by scanning electron microscopy - SEM), pore size and its distribution (as measured by liquid extrusion porosimetry), and porosity (as determined by gravimetric measurement, liquid intrusion method, SEM image analysis and liquid extrusion porosimetry - LEP). Nonwoven micro/nanofibrous scaffolds were formed by uniform bead-free fibers with mean diameters in the range of 0.4 to 7 um. The results indicate that pore size and pore size distribution are strongly associated to fiber diameter. Porosity results were analyzed taking into account the accuracy and limitations of each method. LEP resulted the most suitable technique for measuring through-pore diameter and porosity. In order to compare empirical data of pore size from LEP, a theoretical multiplanar model for stochastic fiber networks was applied. The results predicted by the model were in good agreement with the experimental data provided by LEP for pore mean diameters higher than 1 um. The present study shows the potential of LEP as a valuable instrumental technique for characterizing the porous structure of electrospun fibrous scaffolds.
Fil: Cortez Tornello, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Cuadrado, Teresita Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description Poly(e-caprolactone) micro/nanofibrous scaffolds obtained by electrospinning technique from polymer solutions were characterized in terms of fiber diameter (as measured by scanning electron microscopy - SEM), pore size and its distribution (as measured by liquid extrusion porosimetry), and porosity (as determined by gravimetric measurement, liquid intrusion method, SEM image analysis and liquid extrusion porosimetry - LEP). Nonwoven micro/nanofibrous scaffolds were formed by uniform bead-free fibers with mean diameters in the range of 0.4 to 7 um. The results indicate that pore size and pore size distribution are strongly associated to fiber diameter. Porosity results were analyzed taking into account the accuracy and limitations of each method. LEP resulted the most suitable technique for measuring through-pore diameter and porosity. In order to compare empirical data of pore size from LEP, a theoretical multiplanar model for stochastic fiber networks was applied. The results predicted by the model were in good agreement with the experimental data provided by LEP for pore mean diameters higher than 1 um. The present study shows the potential of LEP as a valuable instrumental technique for characterizing the porous structure of electrospun fibrous scaffolds.
publishDate 2014
dc.date.none.fl_str_mv 2014-05-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27874
Cortez Tornello, Pablo Roberto; Caracciolo, Pablo Christian; Cuadrado, Teresita Raquel; Abraham, Gustavo Abel; Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques; Elsevier Science; Materials Science and Engineering: C; 41; 5-5-2014; 335-342
0928-4931
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27874
identifier_str_mv Cortez Tornello, Pablo Roberto; Caracciolo, Pablo Christian; Cuadrado, Teresita Raquel; Abraham, Gustavo Abel; Structural characterization of electrospun micro/nanofibrous scaffolds by liquid extrusion porosimetry: a comparison with other techniques; Elsevier Science; Materials Science and Engineering: C; 41; 5-5-2014; 335-342
0928-4931
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2014.04.065
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0928493114002574
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0928493114002574?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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