Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice

Autores
Pascuan, Cecilia Gabriela; Urán, Soledad Lucía; Gonzalez Murano, Maria Rosa; Wald, Miriam Ruth; Guelman, Laura Ruth; Genaro, Ana Maria
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Exposure to loud noise levels represents a problem in all regions of the world. Noise exposure is known to affect auditory structures in living organisms. However, it should not be ignored that many of the effects of noise are extra-auditory. In particular, it has been proposed that noise could affect immune system similarly to other stressors. Nevertheless, only few studies so far have investigated the effects of noise on the immune function. The aim of the present work was to investigate the effect of chronic (2 wk) noise (95-97 dB) exposure on immune responses in BALB/c and C57 mice. To ascertain if the effect of noise is similar to other psychological stressors, the effect of chronic restraint –applied for the same time- on immune response was also analyzed. It was found that chronic noise impaired immune-related endpoints in vivo and ex vivo depending on the strain used. Noise, but not restraint, affected C57Bl/6 mouse T-cell-dependent antibody production and ex vivo stimulated T-cell proliferation but had no effect on these parameters in BALB/c mice or their cells. In fact, none of the stressors altered T-cell responses associated with the BALB/c mice. Further, noise exposure induced a decrease in corticosterone and catecholamines levels in BALB/c mice. In contrast, no differences were seen in these parameters for those BALB/c mice under restraint or for that matter C57Bl/6 mice exposed to restraint or noise. The results of these studies indicate that noise could seriously affect immune responses in susceptible individuals. In addition, it may also be concluded that noise possibility should not be considered a classic stressor.
Fil: Pascuan, Cecilia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Urán, Soledad Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Gonzalez Murano, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Wald, Miriam Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Materia
Stress
Corticosterone
Catecholamines
Restraint
Antibody Production
Noise
Mice
T-Cell Proliferation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1831
Acceder
id CONICETDig_f414e67fc204571fe1e5f56895cd390b
oai_identifier_str oai:ri.conicet.gov.ar:11336/1831
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 MicePascuan, Cecilia GabrielaUrán, Soledad LucíaGonzalez Murano, Maria RosaWald, Miriam RuthGuelman, Laura RuthGenaro, Ana MariaStressCorticosteroneCatecholaminesRestraintAntibody ProductionNoiseMiceT-Cell Proliferationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Exposure to loud noise levels represents a problem in all regions of the world. Noise exposure is known to affect auditory structures in living organisms. However, it should not be ignored that many of the effects of noise are extra-auditory. In particular, it has been proposed that noise could affect immune system similarly to other stressors. Nevertheless, only few studies so far have investigated the effects of noise on the immune function. The aim of the present work was to investigate the effect of chronic (2 wk) noise (95-97 dB) exposure on immune responses in BALB/c and C57 mice. To ascertain if the effect of noise is similar to other psychological stressors, the effect of chronic restraint –applied for the same time- on immune response was also analyzed. It was found that chronic noise impaired immune-related endpoints in vivo and ex vivo depending on the strain used. Noise, but not restraint, affected C57Bl/6 mouse T-cell-dependent antibody production and ex vivo stimulated T-cell proliferation but had no effect on these parameters in BALB/c mice or their cells. In fact, none of the stressors altered T-cell responses associated with the BALB/c mice. Further, noise exposure induced a decrease in corticosterone and catecholamines levels in BALB/c mice. In contrast, no differences were seen in these parameters for those BALB/c mice under restraint or for that matter C57Bl/6 mice exposed to restraint or noise. The results of these studies indicate that noise could seriously affect immune responses in susceptible individuals. In addition, it may also be concluded that noise possibility should not be considered a classic stressor.Fil: Pascuan, Cecilia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;Fil: Urán, Soledad Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;Fil: Gonzalez Murano, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;Fil: Wald, Miriam Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;Fil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;Informa Healthcare2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1831Pascuan, Cecilia Gabriela; Urán, Soledad Lucía; Gonzalez Murano, Maria Rosa; Wald, Miriam Ruth; Guelman, Laura Ruth; et al.; Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice; Informa Healthcare; Journal of Immunotoxicology; 11; 1; 7-2013; 78-831547-691X1547-6901enginfo:eu-repo/semantics/altIdentifier/doi/DOI:10.3109/1547691X.2013.800171info:eu-repo/semantics/altIdentifier/url/http://informahealthcare.com/doi/abs/10.3109/1547691X.2013.800171info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/1547691X.2013.800171#abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:29Zoai:ri.conicet.gov.ar:11336/1831instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:29.288CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
title Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
spellingShingle Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
Pascuan, Cecilia Gabriela
Stress
Corticosterone
Catecholamines
Restraint
Antibody Production
Noise
Mice
T-Cell Proliferation
title_short Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
title_full Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
title_fullStr Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
title_full_unstemmed Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
title_sort Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
dc.creator.none.fl_str_mv Pascuan, Cecilia Gabriela
Urán, Soledad Lucía
Gonzalez Murano, Maria Rosa
Wald, Miriam Ruth
Guelman, Laura Ruth
Genaro, Ana Maria
author Pascuan, Cecilia Gabriela
author_facet Pascuan, Cecilia Gabriela
Urán, Soledad Lucía
Gonzalez Murano, Maria Rosa
Wald, Miriam Ruth
Guelman, Laura Ruth
Genaro, Ana Maria
author_role author
author2 Urán, Soledad Lucía
Gonzalez Murano, Maria Rosa
Wald, Miriam Ruth
Guelman, Laura Ruth
Genaro, Ana Maria
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Stress
Corticosterone
Catecholamines
Restraint
Antibody Production
Noise
Mice
T-Cell Proliferation
topic Stress
Corticosterone
Catecholamines
Restraint
Antibody Production
Noise
Mice
T-Cell Proliferation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Exposure to loud noise levels represents a problem in all regions of the world. Noise exposure is known to affect auditory structures in living organisms. However, it should not be ignored that many of the effects of noise are extra-auditory. In particular, it has been proposed that noise could affect immune system similarly to other stressors. Nevertheless, only few studies so far have investigated the effects of noise on the immune function. The aim of the present work was to investigate the effect of chronic (2 wk) noise (95-97 dB) exposure on immune responses in BALB/c and C57 mice. To ascertain if the effect of noise is similar to other psychological stressors, the effect of chronic restraint –applied for the same time- on immune response was also analyzed. It was found that chronic noise impaired immune-related endpoints in vivo and ex vivo depending on the strain used. Noise, but not restraint, affected C57Bl/6 mouse T-cell-dependent antibody production and ex vivo stimulated T-cell proliferation but had no effect on these parameters in BALB/c mice or their cells. In fact, none of the stressors altered T-cell responses associated with the BALB/c mice. Further, noise exposure induced a decrease in corticosterone and catecholamines levels in BALB/c mice. In contrast, no differences were seen in these parameters for those BALB/c mice under restraint or for that matter C57Bl/6 mice exposed to restraint or noise. The results of these studies indicate that noise could seriously affect immune responses in susceptible individuals. In addition, it may also be concluded that noise possibility should not be considered a classic stressor.
Fil: Pascuan, Cecilia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Urán, Soledad Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Gonzalez Murano, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Wald, Miriam Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
description Exposure to loud noise levels represents a problem in all regions of the world. Noise exposure is known to affect auditory structures in living organisms. However, it should not be ignored that many of the effects of noise are extra-auditory. In particular, it has been proposed that noise could affect immune system similarly to other stressors. Nevertheless, only few studies so far have investigated the effects of noise on the immune function. The aim of the present work was to investigate the effect of chronic (2 wk) noise (95-97 dB) exposure on immune responses in BALB/c and C57 mice. To ascertain if the effect of noise is similar to other psychological stressors, the effect of chronic restraint –applied for the same time- on immune response was also analyzed. It was found that chronic noise impaired immune-related endpoints in vivo and ex vivo depending on the strain used. Noise, but not restraint, affected C57Bl/6 mouse T-cell-dependent antibody production and ex vivo stimulated T-cell proliferation but had no effect on these parameters in BALB/c mice or their cells. In fact, none of the stressors altered T-cell responses associated with the BALB/c mice. Further, noise exposure induced a decrease in corticosterone and catecholamines levels in BALB/c mice. In contrast, no differences were seen in these parameters for those BALB/c mice under restraint or for that matter C57Bl/6 mice exposed to restraint or noise. The results of these studies indicate that noise could seriously affect immune responses in susceptible individuals. In addition, it may also be concluded that noise possibility should not be considered a classic stressor.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1831
Pascuan, Cecilia Gabriela; Urán, Soledad Lucía; Gonzalez Murano, Maria Rosa; Wald, Miriam Ruth; Guelman, Laura Ruth; et al.; Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice; Informa Healthcare; Journal of Immunotoxicology; 11; 1; 7-2013; 78-83
1547-691X
1547-6901
url http://hdl.handle.net/11336/1831
identifier_str_mv Pascuan, Cecilia Gabriela; Urán, Soledad Lucía; Gonzalez Murano, Maria Rosa; Wald, Miriam Ruth; Guelman, Laura Ruth; et al.; Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice; Informa Healthcare; Journal of Immunotoxicology; 11; 1; 7-2013; 78-83
1547-691X
1547-6901
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/DOI:10.3109/1547691X.2013.800171
info:eu-repo/semantics/altIdentifier/url/http://informahealthcare.com/doi/abs/10.3109/1547691X.2013.800171
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/1547691X.2013.800171#abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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