Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level

Autores
Bouzat, Cecilia Beatriz
Año de publicación
2012
Idioma
español castellano
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Pentameric neurotransmitter-gated ion channels mediate rapid communication in the nervous system, and include nicotinic (AChR), GABA, glycine and 5-HT3A receptors. They are implicated in important physiological functions, in neurological disorders and they are targets of therapeutic drugs. Receptors are also present in nonneuronal cells and are highly conserved in nematodes, where they are targets of antiparasitic drugs. By combining mutagenesis, cellexpression, patch-clamp recordings and in silico studies we identified key regions involved in the functional connection between agonist binding and channel opening and we defined sites and mechanisms of drugs affecting receptor activation. This information provides a foundation for the understanding of synaptic responses and their modulation. We determined that lymphocytes have neuronal-like synaptic components and express GABAA and neuronal 7 AChRs, which emerge as potential targets for modulating the immune response. We deciphered the composition of C. elegans muscle AChRs and generated transgenic worms carrying mutations in muscle AChR subunits, which mimic those found in patients suffering from congenital myasthenic syndromes (CMS). We postulate that C. elegans is a valid model for studying human CMSs and for drug screening.
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias
Huerta Grande, Córdoba
Argentina
Sociedad Argentina de Investigación en Neurociencias
Materia
RECEPTORES CYS-LOOP
ESTRUCTURA
MECANISMOS MOLECULARES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/234168
Acceder
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spelling Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal levelBouzat, Cecilia BeatrizRECEPTORES CYS-LOOPESTRUCTURAMECANISMOS MOLECULAREShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Pentameric neurotransmitter-gated ion channels mediate rapid communication in the nervous system, and include nicotinic (AChR), GABA, glycine and 5-HT3A receptors. They are implicated in important physiological functions, in neurological disorders and they are targets of therapeutic drugs. Receptors are also present in nonneuronal cells and are highly conserved in nematodes, where they are targets of antiparasitic drugs. By combining mutagenesis, cellexpression, patch-clamp recordings and in silico studies we identified key regions involved in the functional connection between agonist binding and channel opening and we defined sites and mechanisms of drugs affecting receptor activation. This information provides a foundation for the understanding of synaptic responses and their modulation. We determined that lymphocytes have neuronal-like synaptic components and express GABAA and neuronal 7 AChRs, which emerge as potential targets for modulating the immune response. We deciphered the composition of C. elegans muscle AChRs and generated transgenic worms carrying mutations in muscle AChR subunits, which mimic those found in patients suffering from congenital myasthenic syndromes (CMS). We postulate that C. elegans is a valid model for studying human CMSs and for drug screening.Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaXXVII Congreso Anual de la Sociedad Argentina de Investigación en NeurocienciasHuerta Grande, CórdobaArgentinaSociedad Argentina de Investigación en NeurocienciasUniversidad Nacional de Cuyo2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/234168Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Huerta Grande, Córdoba; Argentina; 2012; 41-41CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/wp-content/uploads/2022/01/SAN2012_Huerta-Grande_libro-de-resumenes.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:28:11Zoai:ri.conicet.gov.ar:11336/234168instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:28:11.568CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level
title Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level
spellingShingle Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level
Bouzat, Cecilia Beatriz
RECEPTORES CYS-LOOP
ESTRUCTURA
MECANISMOS MOLECULARES
title_short Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level
title_full Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level
title_fullStr Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level
title_full_unstemmed Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level
title_sort Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level
dc.creator.none.fl_str_mv Bouzat, Cecilia Beatriz
author Bouzat, Cecilia Beatriz
author_facet Bouzat, Cecilia Beatriz
author_role author
dc.subject.none.fl_str_mv RECEPTORES CYS-LOOP
ESTRUCTURA
MECANISMOS MOLECULARES
topic RECEPTORES CYS-LOOP
ESTRUCTURA
MECANISMOS MOLECULARES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pentameric neurotransmitter-gated ion channels mediate rapid communication in the nervous system, and include nicotinic (AChR), GABA, glycine and 5-HT3A receptors. They are implicated in important physiological functions, in neurological disorders and they are targets of therapeutic drugs. Receptors are also present in nonneuronal cells and are highly conserved in nematodes, where they are targets of antiparasitic drugs. By combining mutagenesis, cellexpression, patch-clamp recordings and in silico studies we identified key regions involved in the functional connection between agonist binding and channel opening and we defined sites and mechanisms of drugs affecting receptor activation. This information provides a foundation for the understanding of synaptic responses and their modulation. We determined that lymphocytes have neuronal-like synaptic components and express GABAA and neuronal 7 AChRs, which emerge as potential targets for modulating the immune response. We deciphered the composition of C. elegans muscle AChRs and generated transgenic worms carrying mutations in muscle AChR subunits, which mimic those found in patients suffering from congenital myasthenic syndromes (CMS). We postulate that C. elegans is a valid model for studying human CMSs and for drug screening.
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias
Huerta Grande, Córdoba
Argentina
Sociedad Argentina de Investigación en Neurociencias
description Pentameric neurotransmitter-gated ion channels mediate rapid communication in the nervous system, and include nicotinic (AChR), GABA, glycine and 5-HT3A receptors. They are implicated in important physiological functions, in neurological disorders and they are targets of therapeutic drugs. Receptors are also present in nonneuronal cells and are highly conserved in nematodes, where they are targets of antiparasitic drugs. By combining mutagenesis, cellexpression, patch-clamp recordings and in silico studies we identified key regions involved in the functional connection between agonist binding and channel opening and we defined sites and mechanisms of drugs affecting receptor activation. This information provides a foundation for the understanding of synaptic responses and their modulation. We determined that lymphocytes have neuronal-like synaptic components and express GABAA and neuronal 7 AChRs, which emerge as potential targets for modulating the immune response. We deciphered the composition of C. elegans muscle AChRs and generated transgenic worms carrying mutations in muscle AChR subunits, which mimic those found in patients suffering from congenital myasthenic syndromes (CMS). We postulate that C. elegans is a valid model for studying human CMSs and for drug screening.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
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Book
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info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/234168
Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Huerta Grande, Córdoba; Argentina; 2012; 41-41
CONICET Digital
CONICET
url http://hdl.handle.net/11336/234168
identifier_str_mv Deciphering the function of neurotransmitter-gated ion channels: From the molecular to the animal level; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Huerta Grande, Córdoba; Argentina; 2012; 41-41
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/wp-content/uploads/2022/01/SAN2012_Huerta-Grande_libro-de-resumenes.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
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dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Universidad Nacional de Cuyo
publisher.none.fl_str_mv Universidad Nacional de Cuyo
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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