How membrane lipids control the 3D structure and function of receptors

Autores
Fantini, Jacques; Barrantes, Francisco Jose
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface receptors (non-annular lipids) or less tightly attached to the external surface of the protein (annular lipids). The latter are exchangeable with surrounding bulk membrane lipids on a faster time scale than that of non-annular lipids. Not only do non-annular lipids bind to membrane proteins through stereoselective mechanisms, they can also help membrane receptors acquire (or maintain) a functional 3D structure. Cholesterol is the prototype of membrane lipids that finely controls the 3D structure and function of receptors. However, several other lipids such as sphingolipids may also modulate the function of membrane proteins though conformational adjustments. All these concepts are discussed in this review in the light of representative examples taken from the literature.
Fil: Fantini, Jacques. Aix Marseille University; Francia
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Materia
CHOLESTEROL
GPCR
HOPANOIDS
ION CHANNELS
LIPID RAFTS
SPHINGOLIPIDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99393
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/99393
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling How membrane lipids control the 3D structure and function of receptorsFantini, JacquesBarrantes, Francisco JoseCHOLESTEROLGPCRHOPANOIDSION CHANNELSLIPID RAFTSSPHINGOLIPIDShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface receptors (non-annular lipids) or less tightly attached to the external surface of the protein (annular lipids). The latter are exchangeable with surrounding bulk membrane lipids on a faster time scale than that of non-annular lipids. Not only do non-annular lipids bind to membrane proteins through stereoselective mechanisms, they can also help membrane receptors acquire (or maintain) a functional 3D structure. Cholesterol is the prototype of membrane lipids that finely controls the 3D structure and function of receptors. However, several other lipids such as sphingolipids may also modulate the function of membrane proteins though conformational adjustments. All these concepts are discussed in this review in the light of representative examples taken from the literature.Fil: Fantini, Jacques. Aix Marseille University; FranciaFil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaAmerican Institute of Mathematical Sciences2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99393Fantini, Jacques; Barrantes, Francisco Jose; How membrane lipids control the 3D structure and function of receptors; American Institute of Mathematical Sciences; AIMS Biophysics; 5; 1; 3-2018; 22-352377-9098CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3934/biophy.2018.1.22info:eu-repo/semantics/altIdentifier/url/http://www.aimspress.com/article/10.3934/biophy.2018.1.22info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:23:02Zoai:ri.conicet.gov.ar:11336/99393instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:23:02.938CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv How membrane lipids control the 3D structure and function of receptors
title How membrane lipids control the 3D structure and function of receptors
spellingShingle How membrane lipids control the 3D structure and function of receptors
Fantini, Jacques
CHOLESTEROL
GPCR
HOPANOIDS
ION CHANNELS
LIPID RAFTS
SPHINGOLIPIDS
title_short How membrane lipids control the 3D structure and function of receptors
title_full How membrane lipids control the 3D structure and function of receptors
title_fullStr How membrane lipids control the 3D structure and function of receptors
title_full_unstemmed How membrane lipids control the 3D structure and function of receptors
title_sort How membrane lipids control the 3D structure and function of receptors
dc.creator.none.fl_str_mv Fantini, Jacques
Barrantes, Francisco Jose
author Fantini, Jacques
author_facet Fantini, Jacques
Barrantes, Francisco Jose
author_role author
author2 Barrantes, Francisco Jose
author2_role author
dc.subject.none.fl_str_mv CHOLESTEROL
GPCR
HOPANOIDS
ION CHANNELS
LIPID RAFTS
SPHINGOLIPIDS
topic CHOLESTEROL
GPCR
HOPANOIDS
ION CHANNELS
LIPID RAFTS
SPHINGOLIPIDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface receptors (non-annular lipids) or less tightly attached to the external surface of the protein (annular lipids). The latter are exchangeable with surrounding bulk membrane lipids on a faster time scale than that of non-annular lipids. Not only do non-annular lipids bind to membrane proteins through stereoselective mechanisms, they can also help membrane receptors acquire (or maintain) a functional 3D structure. Cholesterol is the prototype of membrane lipids that finely controls the 3D structure and function of receptors. However, several other lipids such as sphingolipids may also modulate the function of membrane proteins though conformational adjustments. All these concepts are discussed in this review in the light of representative examples taken from the literature.
Fil: Fantini, Jacques. Aix Marseille University; Francia
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
description The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface receptors (non-annular lipids) or less tightly attached to the external surface of the protein (annular lipids). The latter are exchangeable with surrounding bulk membrane lipids on a faster time scale than that of non-annular lipids. Not only do non-annular lipids bind to membrane proteins through stereoselective mechanisms, they can also help membrane receptors acquire (or maintain) a functional 3D structure. Cholesterol is the prototype of membrane lipids that finely controls the 3D structure and function of receptors. However, several other lipids such as sphingolipids may also modulate the function of membrane proteins though conformational adjustments. All these concepts are discussed in this review in the light of representative examples taken from the literature.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99393
Fantini, Jacques; Barrantes, Francisco Jose; How membrane lipids control the 3D structure and function of receptors; American Institute of Mathematical Sciences; AIMS Biophysics; 5; 1; 3-2018; 22-35
2377-9098
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99393
identifier_str_mv Fantini, Jacques; Barrantes, Francisco Jose; How membrane lipids control the 3D structure and function of receptors; American Institute of Mathematical Sciences; AIMS Biophysics; 5; 1; 3-2018; 22-35
2377-9098
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3934/biophy.2018.1.22
info:eu-repo/semantics/altIdentifier/url/http://www.aimspress.com/article/10.3934/biophy.2018.1.22
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Institute of Mathematical Sciences
publisher.none.fl_str_mv American Institute of Mathematical Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781754625490944
score 12.982451

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