Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages

Autores
Tasat, Deborah Ruth; Domingo, Mariela Gisele; Bruno, Marcos Esteban; Guglielmotti, Maria Beatriz; Olmedo, Daniel Gustavo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
As a result of biotribocorrosion, the surface of a titanium (Ti) biomedical device can be a potential source of systemic contamination with Ti nanoparticles (NPs). Although NPs can be chemically similar, differences in particle size may lead to different biological responses. The aim of this experimental study was to determine Ti trace levels in skin appendages and plasma and explore the influence of NP size on trace levels using a murine model. Results showed the presence of Ti traces in the nails, hair, and plasma. The concentration of the smallest NPs (5 Nm) was higher than that of 10 Nm NPs in all the studied samples. Irrespective of NP size, Ti levels were always lower in plasma than in skin appendages. Ti levels were higher in nails than in hair. Ti NPs size influenced trace concentration levels in hair/nails, suggesting that 5 Nm Ti particles are more easily eliminated through these skin appendages. Given that the nails showed the highest levels of Ti, and that these skin appendages are not exposed to agents that can leach out Ti, as occurs with hair, we propose the nails as the most suitable and reliable bioindicator for monitoring systemic contamination with Ti.
Fil: Tasat, Deborah Ruth. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Fil: Domingo, Mariela Gisele. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Bruno, Marcos Esteban. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Biomarker
Hair
Nails
Nanoparticles
Skin Appendages
Titanium
Tribocorrosion
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47727
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/47727
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin AppendagesTasat, Deborah RuthDomingo, Mariela GiseleBruno, Marcos EstebanGuglielmotti, Maria BeatrizOlmedo, Daniel GustavoBiomarkerHairNailsNanoparticlesSkin AppendagesTitaniumTribocorrosionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3As a result of biotribocorrosion, the surface of a titanium (Ti) biomedical device can be a potential source of systemic contamination with Ti nanoparticles (NPs). Although NPs can be chemically similar, differences in particle size may lead to different biological responses. The aim of this experimental study was to determine Ti trace levels in skin appendages and plasma and explore the influence of NP size on trace levels using a murine model. Results showed the presence of Ti traces in the nails, hair, and plasma. The concentration of the smallest NPs (5 Nm) was higher than that of 10 Nm NPs in all the studied samples. Irrespective of NP size, Ti levels were always lower in plasma than in skin appendages. Ti levels were higher in nails than in hair. Ti NPs size influenced trace concentration levels in hair/nails, suggesting that 5 Nm Ti particles are more easily eliminated through these skin appendages. Given that the nails showed the highest levels of Ti, and that these skin appendages are not exposed to agents that can leach out Ti, as occurs with hair, we propose the nails as the most suitable and reliable bioindicator for monitoring systemic contamination with Ti.Fil: Tasat, Deborah Ruth. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; ArgentinaFil: Domingo, Mariela Gisele. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Bruno, Marcos Esteban. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSAGE Publications2017-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47727Tasat, Deborah Ruth; Domingo, Mariela Gisele; Bruno, Marcos Esteban; Guglielmotti, Maria Beatriz; Olmedo, Daniel Gustavo; Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages; SAGE Publications; Toxicologic Pathology; 45; 5; 6-2017; 624-6320192-6233CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/0192623317711808info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0192623317711808info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:03:51Zoai:ri.conicet.gov.ar:11336/47727instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:03:51.935CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
title Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
spellingShingle Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
Tasat, Deborah Ruth
Biomarker
Hair
Nails
Nanoparticles
Skin Appendages
Titanium
Tribocorrosion
title_short Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
title_full Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
title_fullStr Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
title_full_unstemmed Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
title_sort Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages
dc.creator.none.fl_str_mv Tasat, Deborah Ruth
Domingo, Mariela Gisele
Bruno, Marcos Esteban
Guglielmotti, Maria Beatriz
Olmedo, Daniel Gustavo
author Tasat, Deborah Ruth
author_facet Tasat, Deborah Ruth
Domingo, Mariela Gisele
Bruno, Marcos Esteban
Guglielmotti, Maria Beatriz
Olmedo, Daniel Gustavo
author_role author
author2 Domingo, Mariela Gisele
Bruno, Marcos Esteban
Guglielmotti, Maria Beatriz
Olmedo, Daniel Gustavo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biomarker
Hair
Nails
Nanoparticles
Skin Appendages
Titanium
Tribocorrosion
topic Biomarker
Hair
Nails
Nanoparticles
Skin Appendages
Titanium
Tribocorrosion
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv As a result of biotribocorrosion, the surface of a titanium (Ti) biomedical device can be a potential source of systemic contamination with Ti nanoparticles (NPs). Although NPs can be chemically similar, differences in particle size may lead to different biological responses. The aim of this experimental study was to determine Ti trace levels in skin appendages and plasma and explore the influence of NP size on trace levels using a murine model. Results showed the presence of Ti traces in the nails, hair, and plasma. The concentration of the smallest NPs (5 Nm) was higher than that of 10 Nm NPs in all the studied samples. Irrespective of NP size, Ti levels were always lower in plasma than in skin appendages. Ti levels were higher in nails than in hair. Ti NPs size influenced trace concentration levels in hair/nails, suggesting that 5 Nm Ti particles are more easily eliminated through these skin appendages. Given that the nails showed the highest levels of Ti, and that these skin appendages are not exposed to agents that can leach out Ti, as occurs with hair, we propose the nails as the most suitable and reliable bioindicator for monitoring systemic contamination with Ti.
Fil: Tasat, Deborah Ruth. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Fil: Domingo, Mariela Gisele. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Bruno, Marcos Esteban. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description As a result of biotribocorrosion, the surface of a titanium (Ti) biomedical device can be a potential source of systemic contamination with Ti nanoparticles (NPs). Although NPs can be chemically similar, differences in particle size may lead to different biological responses. The aim of this experimental study was to determine Ti trace levels in skin appendages and plasma and explore the influence of NP size on trace levels using a murine model. Results showed the presence of Ti traces in the nails, hair, and plasma. The concentration of the smallest NPs (5 Nm) was higher than that of 10 Nm NPs in all the studied samples. Irrespective of NP size, Ti levels were always lower in plasma than in skin appendages. Ti levels were higher in nails than in hair. Ti NPs size influenced trace concentration levels in hair/nails, suggesting that 5 Nm Ti particles are more easily eliminated through these skin appendages. Given that the nails showed the highest levels of Ti, and that these skin appendages are not exposed to agents that can leach out Ti, as occurs with hair, we propose the nails as the most suitable and reliable bioindicator for monitoring systemic contamination with Ti.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47727
Tasat, Deborah Ruth; Domingo, Mariela Gisele; Bruno, Marcos Esteban; Guglielmotti, Maria Beatriz; Olmedo, Daniel Gustavo; Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages; SAGE Publications; Toxicologic Pathology; 45; 5; 6-2017; 624-632
0192-6233
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47727
identifier_str_mv Tasat, Deborah Ruth; Domingo, Mariela Gisele; Bruno, Marcos Esteban; Guglielmotti, Maria Beatriz; Olmedo, Daniel Gustavo; Titanium Nanoparticle Size Influences Trace Concentration Levels in Skin Appendages; SAGE Publications; Toxicologic Pathology; 45; 5; 6-2017; 624-632
0192-6233
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/0192623317711808
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0192623317711808
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1858305071265087488
score 13.176822

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