Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection

Autores
Farias, Adrian Alejandro; Kremer, Luís Emilio; Allende, Luís; Diaz, Maria del Pilar; Pisano, María Belén; Contigiani, Marta Silvia; Ré, Viviana Elizabeth
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis C virus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART). Methods: This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients. Results: Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (<200 CD4 cells/ml independently of viral load either < or > to100 000 copies/ml), were significantly associated with immunological and virological responses to HAART. Conclusions: These results show further evidence that hepatitis C serostatus is associated with a reduced response to HAART.
Fil: Farias, Adrian Alejandro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Kremer, Luís Emilio. Universidad Nacional de Cordoba. Facultad de Medicina. Hospital Nacional de Clinicas; Argentina
Fil: Allende, Luís. Universidad Nacional de Cordoba. Facultad de Medicina. Hospital Nacional de Clinicas; Argentina
Fil: Diaz, Maria del Pilar. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Haart
Hiv/Hcv Coinfection
Response to Therapy
Cd4 Cell Counts
Viral Load
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22991
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22991
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infectionFarias, Adrian AlejandroKremer, Luís EmilioAllende, LuísDiaz, Maria del PilarPisano, María BelénContigiani, Marta SilviaRé, Viviana ElizabethHaartHiv/Hcv CoinfectionResponse to TherapyCd4 Cell CountsViral Loadhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis C virus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART). Methods: This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients. Results: Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (<200 CD4 cells/ml independently of viral load either < or > to100 000 copies/ml), were significantly associated with immunological and virological responses to HAART. Conclusions: These results show further evidence that hepatitis C serostatus is associated with a reduced response to HAART.Fil: Farias, Adrian Alejandro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Kremer, Luís Emilio. Universidad Nacional de Cordoba. Facultad de Medicina. Hospital Nacional de Clinicas; ArgentinaFil: Allende, Luís. Universidad Nacional de Cordoba. Facultad de Medicina. Hospital Nacional de Clinicas; ArgentinaFil: Diaz, Maria del Pilar. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaOxford University Press2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22991Farias, Adrian Alejandro; Kremer, Luís Emilio; Allende, Luís; Diaz, Maria del Pilar; Pisano, María Belén; et al.; Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection; Oxford University Press; Transactions of the Royal Society of Tropical Medicine and Hygiene; 7; 1; 7-2013; 432-4370035-9203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/trstmh/trt043info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/trstmh/article-abstract/107/7/432/1932911/Determinants-of-immunological-and-virologicalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:19Zoai:ri.conicet.gov.ar:11336/22991instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:20.086CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
title Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
spellingShingle Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
Farias, Adrian Alejandro
Haart
Hiv/Hcv Coinfection
Response to Therapy
Cd4 Cell Counts
Viral Load
title_short Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
title_full Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
title_fullStr Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
title_full_unstemmed Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
title_sort Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
dc.creator.none.fl_str_mv Farias, Adrian Alejandro
Kremer, Luís Emilio
Allende, Luís
Diaz, Maria del Pilar
Pisano, María Belén
Contigiani, Marta Silvia
Ré, Viviana Elizabeth
author Farias, Adrian Alejandro
author_facet Farias, Adrian Alejandro
Kremer, Luís Emilio
Allende, Luís
Diaz, Maria del Pilar
Pisano, María Belén
Contigiani, Marta Silvia
Ré, Viviana Elizabeth
author_role author
author2 Kremer, Luís Emilio
Allende, Luís
Diaz, Maria del Pilar
Pisano, María Belén
Contigiani, Marta Silvia
Ré, Viviana Elizabeth
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Haart
Hiv/Hcv Coinfection
Response to Therapy
Cd4 Cell Counts
Viral Load
topic Haart
Hiv/Hcv Coinfection
Response to Therapy
Cd4 Cell Counts
Viral Load
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis C virus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART). Methods: This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients. Results: Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (<200 CD4 cells/ml independently of viral load either < or > to100 000 copies/ml), were significantly associated with immunological and virological responses to HAART. Conclusions: These results show further evidence that hepatitis C serostatus is associated with a reduced response to HAART.
Fil: Farias, Adrian Alejandro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Kremer, Luís Emilio. Universidad Nacional de Cordoba. Facultad de Medicina. Hospital Nacional de Clinicas; Argentina
Fil: Allende, Luís. Universidad Nacional de Cordoba. Facultad de Medicina. Hospital Nacional de Clinicas; Argentina
Fil: Diaz, Maria del Pilar. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis C virus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART). Methods: This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients. Results: Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (<200 CD4 cells/ml independently of viral load either < or > to100 000 copies/ml), were significantly associated with immunological and virological responses to HAART. Conclusions: These results show further evidence that hepatitis C serostatus is associated with a reduced response to HAART.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22991
Farias, Adrian Alejandro; Kremer, Luís Emilio; Allende, Luís; Diaz, Maria del Pilar; Pisano, María Belén; et al.; Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection; Oxford University Press; Transactions of the Royal Society of Tropical Medicine and Hygiene; 7; 1; 7-2013; 432-437
0035-9203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22991
identifier_str_mv Farias, Adrian Alejandro; Kremer, Luís Emilio; Allende, Luís; Diaz, Maria del Pilar; Pisano, María Belén; et al.; Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection; Oxford University Press; Transactions of the Royal Society of Tropical Medicine and Hygiene; 7; 1; 7-2013; 432-437
0035-9203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/trstmh/trt043
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/trstmh/article-abstract/107/7/432/1932911/Determinants-of-immunological-and-virological
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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